Influence of delaying ocrelizumab dosing in multiple sclerosis due to COVID-19 pandemics on clinical and laboratory effectivenessCOVID-19 대유행으로 인한 다발성 경화증에서 ocrelizumab 투여 지연이 임상 및 실험실 효과에 미치는 영향Article Published on 2021-02-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] MERS, 진단, [키워드] age B cell B cells CD19 clinical consequence COVID COVID-19 Cytometry database Delay disability disease EDSS Effect Effectiveness evaluate Flow independent influence Laboratory Linear regression analysis lockdown lymphocyte multiple sclerosis multivariable Ocrelizumab Pandemics Patient phenotype progression repopulation. searched Sex shown status therapy Treatment [DOI] 10.1016/j.msard.2020.102704 PMC 바로가기 [Article Type] Article
COVID-19 – The clinical consequences of social isolation and the relation with sleep bruxism and comorbiditiesOverviews Published on 2021-01-012022-10-28 Journal: Sleep Science [Category] COVID-19, [키워드] adverse effect Anxiety Anxiety obesity association Bruxism cause clinical condition clinical consequence Comorbidity conditions coronavirus COVID-19 COVID-19 disease disease drug Gastroesophageal reflux highly pathogenic Isolation overlapping pandemic patients professional severity Sleep bruxism sleep quality social isolation the disease [DOI] 10.5935/1984-0063.20210004 PMC 바로가기 [Article Type] Overviews
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations다양한 임상 증상에 걸쳐 SARS-CoV-2 소아에서 혈전성 미세혈관병증의 증거Article Published on 2020-12-082022-09-11 Journal: Blood advances [Category] MERS, SARS, 바이오마커, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection age Biomarker children children with COVID-19 clinical consequence clinical criteria clinical presentation complement Complement activation Complete coronavirus coronavirus disease Coronavirus disease 2019 creatinine criteria determine Diagnostic Criteria disease Elevation elevations endothelial damage enrolled Evidence evidence of Future healthy control Hospitalized Infection Inflammatory interquartile range IQR management median Mild MIS-C MOST Patient patients pediatric Pediatric patient plasma proportion respiratory SARS-CoV-2 SARS-COV-2 infection screened serum creatinine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease subject syndrome tested thrombotic thrombotic microangiopathy was measured [DOI] 10.1182/bloodadvances.2020003471 PMC 바로가기 [Article Type] Article
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune ResponseImmunology Published on 2020-08-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation adaptive Adaptive immune response age all-cause mortality antibody-secreting cell antigenic caused change clinical consequence Combination complementary coronavirus disease COVID-19 Cytokine release syndrome Cytokine storm disease effective Efficacy elderly endothelial injury Enhancing explain follicular Frequency helper T cell immune response Immunity Immunopathogenesis immunosenescence Impact individual Infection Inflamm-aging inflammaging inflammatory state inhibiting innate immune response less management memory T cell naïve neo-antigens occur organ injury Patient Potential pro-inflammatory Prognosis remodeling response SARS-CoV-2 severe COVID-19 susceptible T cell Therapeutic approach thought tissue damage triggered vaccination viral replication virus [DOI] 10.3389/fimmu.2020.01748 PMC 바로가기 [Article Type] Immunology
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research