Kinetics of Neutralizing Antibodies of COVID-19 Patients Tested Using Clinical D614G, B.1.1.7, and B 1.351 Isolates in Microneutralization Assays미세중화 분석에서 임상 D614G, B.1.1.7 및 B 1.351 분리주를 사용하여 테스트한 COVID-19 환자 중화 항체의 동역학Article Published on 2021-05-262022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] acute infection antibody applied B.1.1.7 clinical clinical isolates COVID-19 D614G detectable elicited Evidence First wave Immunity Increasing individuals infected individuals inhibited initial isolate Kinetics Lineage lineages Microneutralization assay NAb NAbs neutralization neutralization test neutralization tests Neutralizing antibodies Patient representing response SARS-CoV-2 SARS-CoV-2 variant sera undetectable variants VOCs was reduced wild-type virus [DOI] 10.3390/v13060996 PMC 바로가기 [Article Type] Article
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 researchCOVID-19 연구를 위한 플라스미드 DNA 출시 SARS-CoV-2 역유전학 시스템 및 코로나바이러스 툴킷Methods and Resources Published on 2021-02-252022-08-13 Journal: PLoS Biology [Category] Biochemistry, COVID-19, MERS, [키워드] accompanied acute respiratory syndrome coronavirus additional expression plasmids antiviral activity apilimod can be used cell lines clinical isolates coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 coronavirus toolkit Coronaviruses COVID-19 COVID-19 research COVID-19 vaccine COVID-19 vaccine design dependent on discovery science Drug testing economic devastation expressed expression plasmids facile single plasmid SARS-CoV-2 reverse genetics system genetics help in vitro transcription infected cells Infectious virus Laboratory morbidity Mortality near-comprehensive panel ORF10 protein Plasmid promising repurposed antiviral activity reagents resource respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 clinical isolates SARS-CoV-2 permissive cell lines SARS-CoV-2 research SARS-CoV-2 toolkit Scientific community severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 TMPRSS2 TMPRSS2 expression transient transfection Vaccine design Viral Viral protein website worldwide pandemic [DOI] 10.1371/journal.pbio.3001091 PMC 바로가기 [Article Type] Methods and Resources
A novel type of colistin resistance genes selected from random sequence space무작위 서열 공간에서 선택된 새로운 유형의 콜리스틴 내성 유전자Research Article Published on 2021-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation activity addition Analysis antibiotic Antibiotic resistance antibiotic treatments auxiliary Bacteria Cell cell envelope chimeric clinical isolates colistin d e novo de novo de novo gene described determinant determine dissemination DNA DNA sequence DNA sequences domain dominant E . coli Escherichia coli Evolution examined example expand expressed expression generate growth growth defects idea in vivo Interaction isolate kinase kinases limit lipopolysaccharide low expression levels mechanism Modification modifications non-coding DNA non-coding region non-coding regions Open reading frame open reading frames Pathogens peptide peptides provided random Randomly resistance gene resistance genes selected sequence Spread subsequent substrate Support Surveillance the cell transfer transmembrane domain Treatment variant [DOI] 10.1371/journal.pgen.1009227 PMC 바로가기 [Article Type] Research Article
Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum유전적 배경과 PfKelch13은 Plasmodium falciparum에서 PfCoronin 돌연변이의 artemisinin 감수성에 영향을 미칩니다Research Article Published on 2020-12-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect African Analysis Artemisinin Asia Biology can not clinical isolates combination therapies combination therapy continent develop domain drug pressure drug resistance Effect elevated Evidence evidence of Evolution focus Future Genetic genetic analysis genetic background genetic determinant genetic determinants Health in vitro independent isolate Laboratory malaria Mask mutant Mutation no evidence of parasite parasites pathway phenotype Plasmodium falciparum Protein reduced referred to representing selected selection pressure South America Spread standard treatment strain survival susceptibility synergy tested Transmission [DOI] 10.1371/journal.pgen.1009266 PMC 바로가기 [Article Type] Research Article
Chest imaging representing a COVID-19 positive rural U.S. populationCOVID-19 양성 미국 농촌 인구를 나타내는 흉부 영상Data Descriptor Published on 2020-11-242022-09-01 Journal: Scientific Data [Category] 변종, 진단, [키워드] America archive available data cDNA characteristic Chest Clinical data clinical isolates Comorbidities Computed tomography COVID-19 COVID-19 crisis COVID-19 diagnosis COVID-19 pandemic demographics disease Early detection Environment etiology Factor feature GenBank help Homo sapien Homo sapiens imaging include increasingly isolate lab lab data location management Metadata National Cancer Institute organism Patient Patient management Population population at risk positive Radiograph Radiographic reported Repository representing Research response to therapy risk Rural area Rural populations Sample SARS-CoV-2 selected sequence Sequence annotation Sequencing technology tested therapeutic options therapy These data Translational research United State United States Viral viral genome whole genome Whole genome sequencing [DOI] 10.1038/s41597-020-00741-6 PMC 바로가기 [Article Type] Data Descriptor
SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patientsSARS-CoV-2 성장, 퓨린 절단 부위 적응 및 급성 감염 입원 COVID-19 환자의 혈청을 사용한 중화Research Article Published on 2020-11-212022-09-10 Journal: The Journal of General Virology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptation angiotensin antigenic target Betacoronavirus both viruses causative agent caused Cell cell lysate cell surface cells characterized cleavage clinical isolates comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths deleted Deletion demonstrated disease expand furin furin cleavage generate glycoprotein growth hACE2 Healthcare system Healthcare systems hospitalized COVID-19 patient host range human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo indirect immunofluorescence inefficient Infection insertion investigated Like MinION Munich neutralization Neutralizing antibodies neutralizing antibody titre neutralizing antibody titres Pathogenesis patients reached receptor respiratory S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Sequencing serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spread to strain the cell the S protein the SARS-CoV-2 variant Vero E6 Vero E6 cell VERO E6 cells virus virus stock virus stocks viruses [DOI] 10.1099/jgv.0.001481 PMC 바로가기 [Article Type] Research Article
Phylogenetic background and habitat drive the genetic diversification of Escherichia coli계통발생적 배경과 서식지가 대장균의 유전적 다양화를 주도Research Article Published on 2020-06-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation adaptive Analysis analyzed Antibiotic resistance association Author Bacteria Bacterial birds clinical isolates clone commensal contribute determine Divergence driven by E . coli early stage element elements epidemiological epidemiologically Escherichia coli Evolution explain facilitate Factor fecal fecal contaminations Frequency gene flow gene transfer Genes Genetic genetic background genetic diversity genetic information Genome group gut bacteria habitat heterogeneous highest horizontal gene Horizontal gene transfer Human humans information investigated isolate isolates Isolation lead lineages linear mammals marker mechanism opportunistic pathogen paradigm pathogen pathogenic Phylogenetic Phylogeny poultry previous study sequence species strain Strains These data traits transfer Variation variations virulence virulence factors water while whole genome widespread wild animal wild animals [DOI] 10.1371/journal.pgen.1008866 PMC 바로가기 [Article Type] Research Article
Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015Short Communication Published on 2019-11-082022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] caused characterized clade clinical isolates collected coronavirus CoV Deletion eight exhibited full length Genome genomic sequences growth growth kinetics Host HUH7 cells Human human infection independent isolate Lineage MERS MERS-CoV MERS-CoV genome Middle East Middle East respiratory syndrome human coronavirus mutant ORF1a ORF3 Patient performed Phylogenetic analysis Phylogeny plasticity Region replicated reported Saudi Arabia Sequencing specimen specimens strain syndrome Vero Vero cells viral isolates viral respiratory zoonotic [DOI] 10.1099/jgv.0.001334 PMC 바로가기 [Article Type] Short Communication
Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7)임상 표현 및 항원 프로필: 말라리아 원충 비박스 백신 후보 - 메로조이트 표면 단백질 7 (PvMSP-7)Research Published on 2019-06-132024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Antigen clinical isolates epitope malaria Plasmodium vivax PvMSP-7 transcriptomics Vaccine [DOI] 10.1186/s12936-019-2826-7 PMC 바로가기 [Article Type] Research
Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates말라리아 박스 화합물의 Plasmodium falciparum 임상 분리주에 대한 항말라리아 활性Article Published on 2017-10-162024-08-12 Journal: International Journal for Parasitology: Drugs and Drug Resistance [Category] 말라리아, [키워드] clinical isolates compounds erythrocytes malaria box Plasmodium potency [DOI] 10.1016/j.ijpddr.2017.10.005 PMC 바로가기 [Article Type] Article