Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patientsArticle Published on 2022-10-012022-11-15 Journal: Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] Admission Analysis antivirals clinical manifestation collected COVID-19 COVID19 Ct value cycle threshold Day Days of symptoms demographic duration of symptom Efficacy evaluate Factor Factors highest Hospital admission hospitalized COVID-19 patient hospitalized patient identify Impact Inclusion laboratory parameter Mortality mortality rate Multivariate analysis Nasopharyngeal swab Patient performed positive predictor reverse transcription rRT-PCR SARS-CoV-2 viral load study population symptoms onset three group Viral load was performed [DOI] 10.1007/s15010-022-01833-8 PMC 바로가기
Black Fungus and beyond: COVID-19 associated infectionsReview article Published on 2022-10-012022-10-05 Journal: Clinical imaging [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] Bacterial black changes in clinical manifestation Clinical outcome Co-infection Complication consolidation COVID-19 COVID-19 infection COVID-19 patient deviation differential diagnosis expected fungal fungus hospitalized COVID-19 patient Infection infections Inflammatory opportunistic infection outcome Patient patient population physician radiologic reported Superimposed infection thrombotic while worsening [DOI] 10.1016/j.clinimag.2022.07.005 [Article Type] Review article
COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment managementReview article Published on 2022-10-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome addition aggravate Asymptomatic caused Characteristics chronic liver disease cirrhosis clinical clinical manifestation Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient Critical death disease dysfunction Epidemic extrapulmonary organs Factors hepatic function Hepatocellular carcinoma hypoxia immune increased risk infection with SARS-CoV-2 inflammatory factor storms Injury liver Liver damage Liver disease liver enzyme Liver function Liver injury liver transplant Liver transplantation management mechanism nonalcoholic fatty liver pathophysiological mechanism Patient patients prevalent public health reperfusion Respiratory disease risk SARS-CoV-2 severe disease Stress Treatment Vaccine [DOI] 10.1016/j.biopha.2022.113568 [Article Type] Review article
Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestationsArticle Published on 2022-10-012022-11-16 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Autopsy Brain calculated case sery CD8 Cell Central nervous system clinical clinical manifestation clinical manifestations correlated correlation COVID-19 described Encephalopathy fatal COVID-19 FIVE highest hospitalisation hypoxic IL-6 illness duration intensive care lesion lesions macrophage activation syndrome microglial microthrombi Neuroinflammation neurological Neurological symptoms Neuropathology no correlation one patient onset of symptoms parameter pathology Patient patients performed Pituitary proportion qRT-PCR quantification retrospective SARS-CoV-2 RNA severe COVID-19 patient systemic inflammation T-cell activation Two patient Vascular [DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
Serological responses to human virome define clinical outcomes of Italian patients infected with SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: International Journal of Biological Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome anti-viral antibody antibody repertoire Antibody Response Antiviral Asymptomatic binding Brescia circulating antibody clinical manifestation Clinical outcome Clinical severity coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19-related symptom disease severity enrolled epitope geographical region hospitalized patient immune increase in infected with SARS-CoV-2 Italian patient Italy memory B-cell outcome pandemic pathogenic patient survival Pneumonia Predictive respiratory infectious disease response responsible SARS-CoV-2 SARS-COV-2 infection significantly strain to define trajectory unique viral peptide viruses [DOI] 10.7150/ijbs.78002 PMC 바로가기
Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysisCOVID-19 돌발 감염의 임상 양상: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Analysis asymptomatic infection Breakthrough infection breakthrough infections clinical manifestation clinical manifestations Clinical outcome Coronavirus 2019 COVID-19 COVID-19 infection COVID-19 infections Delta delta variant Effect Effectiveness examined groups heterogeneity Hospitalization individual individuals Infection Invasive mechanical ventilation Meta-analysis Mortality need for oxygen other variants oxygen oxygen supplementation Patient Relative risk risk Risk factors risk of infection significantly significantly higher statistically statistically significant difference Still study heterogeneity supplemental oxygen systematic review Treatment strategies Vaccine vaccine effectiveness variant variants Web of Science [DOI] 10.1002/jmv.27871 PMC 바로가기 [Article Type] Meta-Analysis
Replication of SARS-CoV-2 Omicron BA.2 variant in ex vivo cultures of the human upper and lower respiratory tractArticle Published on 2022-09-012022-11-16 Journal: EBioMedicine [Category] SARS, 변종, [키워드] airway antibody bronchial Bronchial tissue characterized China clinical manifestation Committee comparable Culture Delta delta variant disease severity Ex vivo explain explained Hong Kong human lung tissue immune evasion Infectious disease Lower respiratory tract lung lung tissue nasal nasal tissue observation omicron Omicron BA.2 parenchymal pathogenicity Patient Region replaced replicated Replication respiratory tissue SARS-CoV-2 strain Strains supported tested tissue Transmissibility Transmission university variant virus viruses wild-type wild-type virus [DOI] 10.1016/j.ebiom.2022.104232 PMC 바로가기