Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusionBerbamine 염산염은 S 단백질 매개 막 융합을 차단하여 SARS-CoV-2 감염을 강력하게 억제합니다Article Published on 2022-04-252022-09-11 Journal: PLoS Neglected Tropical Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral agent Antiviral compounds antiviral drug antiviral drugs approved berbamine caused cell lines Clinical treatment COVID-19 drug effort experiment global pandemic global public health host cells Infection inhibit inhibit SARS-CoV-2 membrane fusion molecular docking outbreak Protein S-mediated cell-cell fusion SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S2 severity subunit tested viral entry viral spike virus entry [DOI] 10.1371/journal.pntd.0010363 PMC 바로가기 [Article Type] Article
Kinetics of Severity Biomarkers and Immunological Features of Methylprednisolone Therapy for Severe COVID-19 Patients중증 COVID-19 환자를 위한 메틸프레드니솔론 요법의 중증도 바이오마커 및 면역학적 특징의 동역학Article Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] “core signature” cytokines. Admission albumin baseline baseline level Biomarker Biomarkers C-reactive protein characterized Clinical characteristics Clinical efficacy clinical outcomes Clinical treatment Cluster correlated Course COVID-19 CRP CXCL10 cytokine cytokine release cytokine release storm Cytokines D-dimer death defined demographics Dexamethasone dimer discharge elevated evaluate FIVE groups Hospital stay IFN-γ IL-6 immune disorder immune disorders immunological IMPROVE involved Kinetics longitudinal MCP-3 mechanism Methylprednisolone multiplex occurred Patient performed receiving remained response severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity significantly supportive therapy Systems biology therapy Treatment two group two groups upregulated [DOI] 10.3389/fimmu.2022.758946 PMC 바로가기 [Article Type] Article
Molecular hydrogen is a potential protective agent in the management of acute lung injuryReview Published on 2022-03-032022-10-30 Journal: Molecular Medicine [Category] COVID-19, [키워드] acute lung injury acute respiratory distress alleviate Anti-inflammation antioxidation Apoptosis autophagy cause caused cell death Clinical treatment COVID-19 critically ill patients demonstrated Diseases Effect Efficacy Inflammation life-threatening Lung injury management mechanism modulation molecular Molecular hydrogen novel coronavirus disease pandemic Pathogenesis Protective pyroptosis ROS Severe respiratory distress syndrome therapeutic effect therapy treatment method [DOI] 10.1186/s10020-022-00455-y PMC 바로가기 [Article Type] Review
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection차등 인터페론-α 아형 유도 면역 시그니처는 SARS-CoV-2 감염 억제와 관련이 있습니다420 Published on 2022-02-072022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundance activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 additive effects Analysis analyzed Antiviral antiviral activity antiviral drug antiviral host response antiviral host responses antiviral response antiviral responses autoantibody Cell culture cellular Clinical treatment coronavirus Course defined disease downstream early administration Effect effector effector molecule epithelial cell epithelial cells Express functional hAEC help Host Human identify IFN-alpha IFN-I IFN-I signaling IFNs IFNα immune immune response immune responses immune signature Immune-mediated Immunity Immunotherapy Inborn error Inborn errors interferon Interferon-α interferons involved knowledge life-threatening negative regulation Pathologies Pathways pleiotropic primary human airway Primary human airway epithelial cells Prophylaxis Protective proteomic Remdesivir respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus signaling cascade Significance subtype Subtypes Support Therapeutic approach therapeutic potential transcriptional transcriptomic analysis Treatment Type type I IFNs type I interferons Viral Viral diseases viral infections virus viruses [DOI] 10.1073/pnas.2111600119 PMC 바로가기 [Article Type] 420
The Investigation of Pulmonary Function Changes of COVID-19 Patients in Three MonthsResearch Article Published on 2022-01-172022-10-31 Journal: Journal of Healthcare Engineering [Category] COVID-19, SARS, [키워드] airway center change Clinical treatment coronavirus disease COVID-19 COVID-19 infection cured discharge dysfunction expiratory function FVC had more impairment investigation Lung function manifested Mild moderate Month novel objective Patient patients Public pulmonary pulmonary dysfunction Pulmonary function pulmonary impairment remained reported Result Retrospective analysis severe COVID-19 severe patients statistically significant ventilation dysfunction Volume was measured was performed Zhejiang [DOI] 10.1155/2022/9028835 PMC 바로가기 [Article Type] Research Article
Patient and Clinical Factors at Admission Affect the Levels of Neutralizing Antibodies Six Months after Recovering from COVID-19입원시 환자 및 임상 적 요인은 COVID-19에서 회복 한 6 개월 후 중화 항체 수준에 영향을 미칩니다.Article Published on 2022-01-022022-09-01 Journal: Viruses [Category] 진단, 치료기술, [키워드] Accuracy Admission AUC value average blood urea clinical Clinical treatment Comorbidity Concentration contribute convalescent coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Corticosteroid Corticosteroids COVID-19 CRP diabete diabetes discharge Factor fibrinogen Guidance individual IVIG Level majority median mixture models Month NAb NAbs Neutralizing antibodies neutralizing antibody neutralizing antibody (NAb) Patient PCT Predictive proportion ROC analysis sensitivity severe acute respiratory syndrome coronavirus (SARS-CoV-2) specificity the median therapy Tongji Hospital two group two groups urea Wuhan Wuhan, China [DOI] 10.3390/v14010080 PMC 바로가기 [Article Type] Article
Serum level of testosterone predicts disease severity of male COVID-19 patients and is related to T-cell immune modulation by transcriptome analysis테스토스테론의 혈청 수준은 남성 COVID-19 환자의 질병 중증도를 예측하고 전사체 분석을 통해 T 세포 면역 조절과 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Activation addition Admission Affiliated Hospital Analysis CD28 changes in Clinical treatment collected correlated correlation COVID-19 COVID-19 patient diagnostic value disease disease severity effective enrolled female patient Female patients ICU immune activation immune modulation immune response independent risk factor Inositol INPP4B lymphocyte male mechanism Medicine Mortality non-ICU occur Patient patients PBMC Pneumonia positively correlated predict progression Regulation remained ROC Curve School serum serum sample serum samples severe disease severity severity of COVID-19 significantly significantly lower Stage T cell T cell activation T-cell Testosterone the disease the patient Transcriptome transcriptome analysis Type university was performed Zhejiang [DOI] 10.1016/j.cca.2021.11.006 PMC 바로가기 [Article Type] Article
Efficacy and safety of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis caused by novel coronavirus disease A protocol for Bayesian network meta-analysis새로운 코로나 바이러스 질병으로 인한 폐 섬유증에서 현대 의학과 한약의 조합의 효능 및 안전성 베이지안 네트워크 메타 분석을위한 프로토콜6700 Published on 2021-12-232022-08-31 Journal: Medicine [Category] meta-analysis, 임상, 치료제, [키워드] Analysis Bayesian caused Chinese choice clinical Clinical significance Clinical studies Clinical treatment collaboration Combination coronavirus coronavirus disease COVID-19 Data processing database deficiency develop discharge drug Effectiveness Efficacy and safety eligibility criteria English evaluate Evidence fibrosis Health hierarchy hospital Inflammation Inflammatory Lung fibrosis medication Meta-analysis modern medicine Network meta-analysis New New coronavirus NMA novel Novel coronavirus novel coronavirus disease Patient positive protocol pulmonary fibrosis pulmonary inflammation Randomized controlled trial ranking recommendation registration number Research screened Stata Support TCM Traditional Chinese medicine Treatment treatment methods various treatment various treatments was used [DOI] 10.1097/MD.0000000000028282 PMC 바로가기 [Article Type] 6700
Comparing the outcomes of treatment with INF-β 1-a (interferon beta-1a) and IFN-β 1-b (interferon beta-1b) among COVID-19 inpatients코로나19 입원환자 중 INF-β 1-a(인터페론베타-1a)와 IFN-β1-b(인터페론베타-1b) 치료 결과 비교Comparative Study Published on 2021-12-012022-09-11 Journal: International immunopharmacology [Category] SARS, 치료법, 치료제, [키워드] addition Clinical improvement Clinical treatment COVID-19 COVID-19 treatment discharge drug duration of hospitalization Effect evaluated Factors Frequency hospital Hospital stay Hospitalization ICU ICU admission IFN-β IFNβ Inpatient Inpatients interferon interferon beta Interferon beta-1a Interferon beta-1b intervention group intubation Laboratory mechanical ventilation median medication medications Mortality mortality rate no significant difference Other outcomes outcome outcomes patients with COVID-19 Primary outcome recipient recipients Secondary outcomes significant difference statistically significant study group the disease Treatment two group two groups were assessed [DOI] 10.1016/j.intimp.2021.108241 PMC 바로가기 [Article Type] Comparative Study