Monkeypox virus replication underlying circadian rhythm networksReview Published on 2023-02-012023-06-10 Journal: Journal of Neurovirology [Category] Fulltext, 원숭이두창, [키워드] chronobiology Circadian clocks Clinical treatment Infection medication Monkeypox Rhythms vaccination virus [DOI] 10.1007/s13365-023-01118-2 PMC 바로가기 [Article Type] Review
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main ProteaseArticle Published on 2022-10-072022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome ADME ADMET antiviral drug betweenness Betweenness centrality binding site catalytic dyad Clinical treatment complex coronavirus COVID-19 database docking experiments drugs enzyme highest in silico In silico methods in vitro in vivo inhibitor inhibitory inhibitory effect Ligand molecular docking molecular dynamics MPro mutated variant natural natural products network network analysis offer pandemic Population potential mechanism predicted product protease Protein reported residue responsible risk SARS-CoV-2 severe COVID-19 Spread the SARS-CoV-2 trajectory Vaccine Vaccines viral replication WHO World Health Organization [DOI] 10.1007/s00894-022-05334-1 PMC 바로가기
A quantitative RT-qLAMP for the detection of SARS-CoV-2 and human gene in clinical applicationArticle Published on 2022-10-012022-11-16 Journal: Microbial Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] applied BBIBP-CorV Beta clinical sample clinical samples Clinical treatment cycle threshold Delta demonstrated detect evaluate evaluated fluorescent full-length help human gene inactivated isothermal isothermal amplification linear linear relationship management omicron pandemic Patient physician positive qPCR Quantitative required RNA RT-qPCR SARS-CoV-2 swab samples threshold Transcription variants of SARS-CoV-2 Viral load viral loads viral particle was used [DOI] 10.1111/1751-7915.14112 PMC 바로가기
Applications of human organoids in the personalized treatment for digestive diseasesArticle Published on 2022-09-272022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] application approach build Chemotherapy Clinical treatment CRISPR-Cas9 digestive digestive system disease Diseases dose Drug screening epithelial facilitated Genetic helping highlight human physiology in vitro include Infection Intervention mechanism model system organ Organoid over pathogenic pathogenic mechanism Patient Perspective physiological Research SARS-CoV-2 targets test model therapy tissue Traditional Treatment [DOI] 10.1038/s41392-022-01194-6 PMC 바로가기
Therapeutic prospects of ceRNAs in COVID-19Article Published on 2022-09-202022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] antiviral therapy applied caused Cell ceRNA Chinese circRNA Clinical treatment competing COVID-19 digestive drug effective drug GAS5 help immune Immunotherapy lncRNA Long MALAT1 microRNA miRNA miRNAs NEAT1 New coronavirus noncoding RNA Novel coronavirus patients with COVID-19 potential therapeutic target predict predicted PTEN reproductive Research RNA Safe SARS-CoV-2 Spread therapeutic target therapy TUG1 [DOI] 10.3389/fcimb.2022.998748 PMC 바로가기
Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensorsArticle Published on 2022-09-152022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody antibody fragment antigen detection binding Clinical treatment clone coronavirus demonstrated diagnose effective Fab fluorescent Health help Human monoclonal antibody human SARS-CoV-2 IgG neutralize neutralizing antibody outbreak Prevent public health S protein S1 domain SARS-CoV-2 selected spike glycoprotein spread of COVID-19 viral infection viral infections virus detection [DOI] 10.1038/s41598-022-19699-z PMC 바로가기
Shanghai expert consensus on clinical protocol for traditional Chinese medicine treatment of COVID-19 among the elderly population (second edition)노인 인구 중 COVID-19의 중국 전통 의학 치료를 위한 임상 프로토콜에 대한 상하이 전문가 합의(2판)Practice Guideline Published on 2022-09-012022-09-11 Journal: Journal of integrative medicine [Category] COVID19(2023년), SARS, 변종, 임상, 치료법, [키워드] Aged China Chinese clinical clinical experience Clinical treatment Consensus coronavirus disease Coronavirus disease 2019 COVID-19 elderly Elderly population expert expert consensus Medicine omicron Omicron variant Population protocol provide recommendation Shanghai therapeutic efficacy Traditional Traditional Chinese medicine Traditional Chinese medicine treatment Treatment treatment approach treatment approaches variant [DOI] 10.1016/j.joim.2022.06.001 PMC 바로가기 [Article Type] Practice Guideline
Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)Droplet Digital PCR(RT-ddPCR)을 사용한 SARS-CoV-2 Omicron 변이체의 빠르고 정확한 식별Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Allelic discrimination amino acids B.1.1.529 B.1.1.529. Clinical treatment clinician Concentration confounding factor Delta described develop digital PCR Efficacy Frequency genome sequence Genome sequences genotyping identify Laboratory medium Mutation mutations NGS omicron Omicron variants positive Prevalence primer probe sequences problem professionals Protein public health Rapid reaction Receptor binding domain respiratory viruses RNA robust S-gene SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants Sensitivity and specificity shifting specimen spike Spike protein state substantial reduction substantial reductions susceptibility tested the SARS-CoV-2 therapy Transmission Transport transport medium Vaccine vaccine efficacy variant variants Variation Washington [DOI] 10.1016/j.jcv.2022.105218 PMC 바로가기 [Article Type] Article
Successful recruitment of monolingual Spanish speaking Latinos to university phase II and III outpatient COVID-19 clinical treatment trials in Northern CaliforniaClinical Trial Published on 2022-09-012022-10-05 Journal: Contemporary clinical trials [Category] 유전자 메커니즘, 임상, 진단, 치료법, [키워드] authorization Clinical treatment clinical trial contribute COVID-19 Emergency Enrollment EUA FDA Health Latino Mild Moderate COVID-19 monoclonal antibody Outpatient patients Population receive recruited recruitment research coordinator Spanish Stanford University Treatment treatment trial Trial with COVID-19 [DOI] 10.1016/j.cct.2022.106891 [Article Type] Clinical Trial