conjugate – Page 3 – Communicable Diseases Research

Bacterial ligands as flexible and sensitive detectors in rapid tests for antibodies to SARS-CoV-2

SARS-COV-2에 대한 항체에 대한 빠른 시험에서 유연하고 민감한 검출기로서의 박테리아 리간드

Research Paper

Published on 2022-02-112022-09-01
Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, 치료법,

[키워드] 95% CI Abstract Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition alternatives analyzed anti-SARS-CoV-2 antibodies antibody applied Bacterial binding Broad-specific ligands cats conjugate Coronavirus-2 defined Design of experiment detectable Diagnosis diagnostic diagnostic methods diagnostic sensitivity Diseases experimental design flexibility flexible fraction gold Gold nanoparticle Gold nanoparticles human serum immune response immunoassay immunodominant Immunoglobulin Infectious diseases Lateral lateral flow immunoassay LFIA LFIAs Ligand molecular nucleocapsid protein Patient POCT point-of-care test point-of-care tests positive Protein protein A Proteins Rapid test reactivity respiratory robustness SARS-CoV-2 selective selectivity sensitivity serological Serological testing serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Streptococcal supplementary material Typical Viral viral antigens with COVID-19
[DOI] 10.1007/s00216-022-03939-2 PMC 바로가기 [Article Type] Research Paper

Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern

자가 보조 지단백질 접합체 αGalCer-RBD는 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다

Article

Published on 2022-02-102022-09-11
Journal: Journal of medicinal chemistry [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agonist Alpha Antigen approach B.1.1.529 best Beta Cell Cellular responses concern conjugate coronavirus COVID-19 pandemic COVID-19 vaccine cross-neutralization develop domain effective effective vaccine Effective vaccines humoral iNKT lipoprotein Liposome natural killer neutralization omicron potent Protein RBD Receptor-binding domain respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spike protein subunit vaccines T cell the RBD Vaccine Vaccines variant variants of concern Viral viral spike protein
[DOI] 10.1021/acs.jmedchem.1c02000 PMC 바로가기 [Article Type] Article

Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

중증 급성 호흡기 증후군 코로나바이러스 2 및 에볼라 바이러스에 대한 렘데시비르의 지방 아실 접합체의 합성 및 항바이러스 활성

Article

Published on 2021-12-152022-09-11
Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제,

[키워드] A significant reduction acute respiratory syndrome antiviral activities antiviral activity antiviral agent Antiviral agents Calu3 CaLu3 cells characterization comparable Compound conjugate Conjugates coronavirus derivative derivatives Ebola Ebola virus EBOV Effectiveness exhibited fatty Fatty acid fatty acids Fatty acyl-RDV conjugates half-life Human plasma IMPROVE in viral in vitro less mono physical purification RDV reduction in remained Remdesivir Replication RNA synthesis SAR SAR-CoV-2 SARS-CoV-2 selected shown Structure-activity relationships (SAR). synthesis these compound these compounds Transcription VeroE6 cells Viral RNA viral RNA synthesis
[DOI] 10.1016/j.ejmech.2021.113862 PMC 바로가기 [Article Type] Article

Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCR

SDS-PMA 지원 RT-qPCR을 통한 PCR 양성 샘플의 감염성 SARS-CoV-2의 신속한 측정

Article

Published on 2021-11-252022-09-11
Journal: The Science of the total environment [Category] SARS, 치료기술,

Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 Replication

Article

Published on 2021-10-302022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Design, Microwave-Assisted Synthesis and In Silico Prediction Study of Novel Isoxazole Linked Pyranopyrimidinone Conjugates as New Targets for Searching Potential Anti-SARS-CoV-2 Agents

Article

Published on 2021-10-102022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,

Targeting SARS-CoV-2 Variants with Nucleic Acid Therapeutic Nanoparticle Conjugates

Brief Report

Published on 2021-10-012022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Covalent functionalization of polypropylene filters with diazirine–photosensitizer conjugates producing visible light driven virus inactivating materials

Article

Published on 2021-09-242022-10-29
Journal: Scientific Reports [Category] Coronavirus, SARS,

D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation

Accelerated Communication

Published on 2021-09-242022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] 3DVA, three-dimensional variability analysis ACE2, angiotensin converting enzyme 2 Alter approach binding Characteristics cold-induced unfolding conformational conjugate COVID-19 pandemic Cryo-electron microscopy CTF, contrast transfer function D614G D614G mutation demonstrated denaturation differential scanning fluorimetry dominant DSC, differential scanning calorimetry DSF, differential scanning fluorimetry ENhance exceptional exhibited host receptor mechanism Microscopy molecular basis Multiple Mutation NSEM, negative staining electron microscopy analysis physiological protein stability RBD, receptor-binding domain RBDs RBM, receptor-binding motif Receptor-binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 significantly Spike protein stability staining the SARS-CoV-2 the spike protein thermal stability Thermodynamics Vaccine development variant viral fitness Viral protein virus WT, wild type
[DOI] 10.1016/j.jbc.2021.101238 PMC 바로가기 [Article Type] Accelerated Communication

Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate

Article

Published on 2021-01-212022-10-28
Journal: Vaccines [Category] COVID-19,