Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post–COVID-19 Convalescent Samples전염병 전 및 코로나19 이후 회복기 샘플에서 SARS-CoV-2에 대한 혈청 교차 반응성 항체 및 기억 반응 검출Major Articles and Brief Reports Published on 2021-10-152022-09-10 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 19 2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adults Anti-S1 anti–SARS-CoV-2 IgG antibody antibodies antibody Antibody titer Antibody titers antigens children collected common human coronavirus (HCoV)-HKU1 convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 correlated CoV COVID COVID-19 cross cross-reactive cross-reactive antibody demonstrated detectable detection domain effective Endemic endemic human coronavirus endemic human coronaviruses enzyme enzyme-linked immunosorbent assays HCoV HCoVs HKU1 IgG antibodies Immunity Immunological memory increase Infection investigated lead less memory response Neutralization assay Neutralizing activity NL63 notable novel coronaviruses nucleocapsid protein OC43 Promoting proportion reactive immunity respiratory response Result Sample SARS SARS-CoV-2 SARS-CoV-2 pseudotyped virus SARS-CoV-2 S1 sera serum antibody serum sample serum samples severe disease susceptible β-coronavirus β-Coronaviruses [DOI] 10.1093/infdis/jiab333 PMC 바로가기 [Article Type] Major Articles and Brief Reports
Weak Cross-Lineage Neutralization by Anti SARS-CoV-2 Spike Antibodies after Natural Infection or Vaccination Is Rescued by Repeated Immunological StimulationArticle Published on 2021-10-022022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Amino acid analyzed anamnestic response anti-spike antibodies B.1.617.2 BAU binding convalescent COVID-19 patient COVID cross-neutralization cross-neutralizing delta variant dose effective Efficacy elicit Evolution humans immunological in vitro Infection Lineage lineages natural natural immunity natural infection Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing antibody response predict Reinfection repeated SARS SARS-CoV-2 sera single dose spike Stimulation subject the spike protein vaccination Vaccine vaccine dose [DOI] 10.3390/vaccines9101124 PMC 바로가기 [Article Type] Article
Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months6개월 동안 입원부터 회복까지 COVID-19 환자의 SARS-CoV-2 유도 체액 면역 반응의 지속 가능성Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] MERS, SARS, 진단, 치료기술, [키워드] acquired immunity age all the patients analyzed anti-SARS-CoV-2 antibody capture chemiluminescence immunoassay CLIA convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 antibody COVID-19 patient COVID-19 symptoms detect dynamic exhibit Gender group help herd immunity Hospitalization Hospitalized humoral immune response humoral responses IgG antibody IgM IgM antibodies IgM/IgG Immunity induced investigated Month N protein observation over Patient peaked persistence positive Receptor binding domain reduced reducing Reinfection response retrospective cohort study risk S protein SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severity specimen sustainability sustained the patient titers titers of IgG understanding undetectable vaccination Wuhan [DOI] 10.1007/s12250-021-00360-4 PMC 바로가기 [Article Type] Article
Kinetics of SARS-CoV-2 Specific and Neutralizing Antibodies over Seven Months after Symptom Onset in COVID-19 PatientsResearch Article Published on 2021-09-222022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval acute phase acute respiratory syndrome administration age anti-SARS-CoV-2 antibody antibodies antibody Characteristics China collected conducted convalescent COVID-19 patient Convalescent patients coronavirus coronavirus disease COVID-19 COVID-19 convalescent patient COVID-19 patient Dilution discharge discharged disease severity enrolled Evidence Factor Follow-up follow-up period follow-up time geometric mean titer GMT hospital IgG IgM IgM/IgG immune response inhibitory interquartile range Jiangsu Kinetics male median Month natural infection Neutralizing activity neutralizing antibody Onset participant Patient patients persistence plasma sample produced SARS-CoV-2 serological seropositive serum sample severity significantly higher significantly lower Specific Standard deviation symptom onset tested Vaccine virus dynamics with COVID-19 [DOI] 10.1128/Spectrum.00590-21 PMC 바로가기 [Article Type] Research Article
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccinationResearch Article Published on 2021-09-032022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] B.1.1.7 B.1.351 binding binding kinetics circulating Cohort convalescent COVID-19 patient COVID-19 convalescent patient description detectable evade exhibited hospitalized patient human immunity humoral immune response implication individuals Infection monoclonal natural infection neutralization Neutralizing neutralizing antibody Neutralizing titer P.1 Patient Pfizer-BioNTech pre-existing immunity PROTECT recipient reduced reduction in reductions in SARS-CoV-2 SARS-CoV-2 variant spike subsequent susceptibility vaccination Vaccine vaccinee VoC VOCs while with COVID-19 [DOI] 10.1126/sciadv.abj5365 PMC 바로가기 [Article Type] Research Article
Mechanical activation of spike fosters SARS-CoV-2 viral infection스파이크의 기계적 활성화는 SARS-CoV-2 바이러스 감염을 촉진합니다Article Published on 2021-08-312022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 진단, [키워드] accelerate ACE2 ACE2 binding Activation Anti-S1 antibody binding binding domain blocking antibody caused complex convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 pandemic D614G Detachment domain faster force host cell host cell membrane Host receptors Invasion Mechanical Molecular biology mutant Neutralizing outbreak Prevent Receptor-binding domain recognize reduce Rotation S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 viral infection SARS2 Spike protein structural biology tensile tensile force therapeutic strategy variant Viral viral entry [DOI] 10.1038/s41422-021-00558-x PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum회복기 및 BNT162b2 백신 접종 혈청에 의한 SARS-CoV-2 변이체의 중화Article Published on 2021-08-262022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] (alpha (Beta age Alpha anti-spike antibodies anti-spike antibody Antibody titers B.1.1.7 B.1.351 BNT162b2 BNT162b2 vaccine Cohort convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent serum COVID-19 patients Effective vaccines escape evaluate human sera increased risk infect lead less neutralization neutralized neutralizing activities Neutralizing antibody titer neutralizing antibody titers of BNT162b2 Patient patient age Re-infection recipient reduced RNA vaccines SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serum serum antibodies vaccinated individuals Vaccine variant variants [DOI] 10.1038/s41467-021-25479-6 PMC 바로가기 [Article Type] Article
Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities동반 질환이 없는 회복기 COVID-19 환자는 다양한 질병 중증도에도 불구하고 시간이 지남에 따라 유사한 면역 표현형을 나타냅니다Immunology Published on 2021-08-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] abrogation affected analyzed asymptomatic infection caused Comorbidities convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients correlated COVID-19 COVID-19 cohort detectable disease course disease severity disease severity assessment display flow cytometric Host immune response immune immune signature immunological immunomonitoring immunophenotype Infection majority mononuclear cell mononuclear cells over Patient PBMCs Peripheral blood Peripheral blood mononuclear cells phenotype Respiratory failure risk factor SARS-CoV-2 SARS-COV-2 infection serum severe respiratory failure stratified T cells the disease time transcriptomics unique [DOI] 10.3389/fimmu.2021.601080 PMC 바로가기 [Article Type] Immunology
Longitudinal analysis of antibody decay in convalescent COVID-19 patients회복기 Covid-19 환자에서 항체 붕괴의 종단 분석Article Published on 2021-08-182022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis anti-N antibodies anti-N antibody anti-N IgG antibody antibody quantification Architect Blood blood sample Blood samples clinically collected convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patients Cutoff decrease dependent on Determining Donor donors faster IgG IgG level IgG levels IgG test immune response Immunoglobulin Immunoglobulin G immunology include infection with SARS-CoV-2 Infectious diseases initial levels of antibody Linear model longitudinal maintain majority measure outcome Patient quantified reduction respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 specific antibodies SARS-CoV-2 virus Seven severe acute respiratory syndrome Coronavirus subject sustainability threshold [DOI] 10.1038/s41598-021-96171-4 PMC 바로가기 [Article Type] Article
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questionsCOVID-19 회복기 혈장 기증자의 항체 지수: 답이 없는 질문Original Article Published on 2021-08-162022-09-12 Journal: Clinics [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response association candidate Care characterized Clinical characteristics clinical manifestation contagiousness convalescent COVID-19 patient convalescent plasma coronavirus correlated COVID-19 Diagnosis disease severity Evolution Health hypothese IgA IgG IgG antibody immune responses Immunity immunoglobulin A Infection Mild moderate neutralize not differ Patient polymerase chain positive presenting professional question raised SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe symptoms severity significantly significantly higher subject Symptom symptomatic Symptoms the antibody the disease viral clearance virus [DOI] 10.6061/clinics/2021/e2818 PMC 바로가기 [Article Type] Original Article