convalescent COVID-19 patient – Communicable Diseases Research

The impact of CoronaVac on the neutralization breadth and magnitude of the antibody response to SARS-CoV-2 viruses

Article

Published on 2022-09-202022-11-15
Journal: Frontiers in Immunology [Category] SARS, 변종, 진단,

Comparative performance data for multiplex SARS-CoV-2 serological assays from a large panel of dried blood spot specimens

Research article

Published on 2022-08-282022-10-05
Journal: Heliyon [Category] 유전자 메커니즘,

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients

혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다

Article

Published on 2022-08-232022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단,

[키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19
[DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article

Humoral and cellular response in convalescent COVID-19 lupus patients

회복기 COVID-19 루푸스 환자의 체액 및 세포 반응

Article

Published on 2022-08-122022-09-11
Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법, 치료제,

[키워드] accumulated adaptive Analysis analyzed antibodies antibody Antibody Response Antibody titer Antibody titers CD8 cellular response changes in collected confirmed cases confirmed COVID-19 case convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients COVID-19 COVID-19 disease COVID-19 incidence COVID-19 infection COVID-19 susceptibility declined decrease died dose dysregulation evaluated flow cytometry Gene expression analysis General population Health care higher risk Hospital admission humoral Humoral and cellular responses hypocomplementemia IgG antibodies immune dysregulation immune response immunological immunological profile Immunological studies Immunosuppression immunosuppressive immunosuppressive therapy impair incidence increase in Infection intensive care lack longitudinal longitudinal changes Lupus medical record memory cell Mild Patient patients PBMC PBMCs PCR-confirmed COVID-19 Prednisone predominant prospective cohort reduction required risk factor Risk factors SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody severe COVID-19 disease severe disease severity Signaling SLE Surveillance susceptibility sustained Symptom symptom onset T cell Th17 Th2 response therapy were measured
[DOI] 10.1038/s41598-022-17334-5 PMC 바로가기 [Article Type] Article

The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies

수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화

Article

Published on 2022-07-132022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while
[DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article

Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing

단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능

Article

Published on 2022-07-012022-09-11
Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone
[DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article

Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro

기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다

Article

Published on 2022-06-282022-09-11
Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used
[DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article

Salivary antibodies are detected with a commercial anti-SARS-CoV-2 assay only after two doses of vaccine using serum thresholds

타액 항체는 혈청 역치를 사용하여 백신을 2회 접종한 후에만 상용 항-SARS-CoV-2 분석으로 검출됩니다.

Article

Published on 2022-06-012022-09-11
Journal: Clinical biochemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

Trajectory patterns of SARS-CoV-2 neutralising antibody response in convalescent COVID-19 patients

Research

Published on 2022-05-192022-10-05
Journal: Communications Medicine [Category] 치료기술, 치료법,

[키워드] Adaptive immune response Analysis association blood sample Characteristics chronic illnesses Clinical data collected contribute convalescent COVID-19 patient convalescent patient COVID-19 patient diagnosis of SARS-CoV-2 Health heterogeneity Hong Kong Infection initial laboratory data latent class neutralising antibody occur Older Patient performed Prevent Re-infection Regression model Result risk SARS-CoV-2 SARS-COV-2 infection Seroconversion subject subsequent surveillance data sVNT symptomatic symptomatic patient Symptomatic patients tested the SARS-CoV-2 trajectory Vaccination strategy Variability virus clearance Virus neutralisation were measured
[DOI] 10.1038/s43856-022-00119-2 [Article Type] Research

Peripheral Neuropathy in Patients Recovering from Severe COVID-19: A Case Series

중증 COVID-19에서 회복 중인 환자의 말초 신경병증: 사례 시리즈

Article

Published on 2022-04-082022-09-11
Journal: Medicina [Category] COVID19(2023년), SARS, 치료기술,

[키워드] age alteration Care chronic disease comparison convalescent COVID-19 patient convalescent COVID-19 patients convalescent phase coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient disability discharge enrolled evaluate exercise Exercise capacity for inclusion In-hospital males manifestation material Mononeuropathy nervous system neurological manifestations Neuropathy nine objective occupational medicine outcome participant Patient patients peripheral Peripheral nervous system Peroneal nerve Polyneuropathy Prevalence proportion pulmonary Pulmonary function pulmonary rehabilitation rehabilitation reported Result risk SARS-CoV-2 screened Sery severity significant difference study groups unit
[DOI] 10.3390/medicina58040523 PMC 바로가기 [Article Type] Article