Regenerable and high-throughput surface plasmon resonance assay for rapid screening of anti-SARS-CoV-2 antibody in serum samples혈청 샘플에서 항-SARS-CoV-2 항체의 신속한 스크리닝을 위한 재생 가능한 고처리량 표면 플라즈몬 공명 분석Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anti-SARS-CoV-2 antibody antibody Antibody test antibody tests association can not channel clinical sample clinical samples Concentration Convalescent patients coronavirus current Detection limit effective ELISA ELISA kit enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibit fluorescent High-throughput histidine mass offer Protein reached reagents reduced reproducibility respiratory S1 protein SARS-CoV-2 SARS-CoV-2 spike sensor serological serological measurement serological measurements serum sample serum samples severe acute respiratory syndrome Coronavirus speed SPR surface plasmon surface plasmon resonance threshold value tris tris-NTA chip. [DOI] 10.1016/j.aca.2022.339830 PMC 바로가기 [Article Type] Article
A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article
Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples혈액 샘플에서 중화 SARS-CoV-2-S1 항체를 검출하기 위한 완전 자동화 분석의 기초로서 SARS-CoV-2-S1 ACE-2 수용체 상호작용의 적용Article Published on 2022-05-012022-09-11 Journal: Journal of Immunological Methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE-2 receptor ACE-2 receptor binding inhibition assay anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers application automated binding blood sample Blood samples BNT162b2 Concentration Control convalescent patient Convalescent patients detect determine Diagnostic method EliA high correlation Interaction large cohort mRNA mRNA-1273 neutralization test Neutralizing Neutralizing antibodies neutralizing antibody neutralizing antibody titers Phadia plaque reduction neutralization PRNT provide quantified Quantitative SARS-CoV-2 SARS-CoV-2 S1 protein Sensitivity and specificity [DOI] 10.1016/j.jim.2022.113258 PMC 바로가기 [Article Type] Article
Comparative analyses of IgG/IgA neutralizing effects induced by three COVID-19 vaccines against variants of concern3가지 COVID-19 백신이 우려하는 변이체에 대해 유도된 IgG/IgA 중화 효과의 비교 분석Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition All participants Alpha Analysis analyzed anti-SARS-CoV-2 antibody Antibody titer Antibody titers B.1.1.7 B.1.351 B.1.617.2 Beta BNT162b2 ChAdOx1 circulating variant circulating variants Comparative convalescent convalescent individual convalescent individuals convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 vaccine Delta delta variant demonstrated E484K Efficacy heterogeneous highest IgA IgA antibodies IgA responses IgG IgG and IgA antibodies IgG response immunized in some individuals Messenger RNA mRNA mRNA-1273 mRNA-based vaccine neutralization neutralization ability neutralization capacity neutralization titer neutralize neutralizing capacity neutralizing effect of BNT162b2 patients positive Receptor binding domain recipients reported respiratory robust S1 IgG SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 WT serum serum sample serum samples severe acute respiratory syndrome Coronavirus specific antibodies Spike protein tested Vaccine Vaccines variant variants variants of concern virus Virus neutralization virus-specific antibodies was determined wild type WT virus [DOI] 10.1016/j.jaci.2022.01.013 PMC 바로가기 [Article Type] Article
Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19경증 또는 중증 COVID-19 환자와 COVID-19 백신 1차 및 2차 접종 후 항체 반응 비교Comparative Study Published on 2022-03-012022-09-11 Journal: The Korean journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Adult patients analyzed antibody formation Antibody Response Antibody responses blood sample Blood samples BNT162b2 BNT162b2 vaccine ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine collected comparable convalescent patient Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 vaccination COVID-19 vaccine dose enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay first dose healthcare healthcare worker homologous immune response immune responses Immunity Immunoglobulin Immunoglobulin G Infection intervals Mild mRNA vaccination Patient patients SARS-CoV-2 SARS-CoV-2 variant second dose severe COVID-19 single dose Spike protein the antibody response vaccine platform Vaccines [DOI] 10.3904/kjim.2021.409 PMC 바로가기 [Article Type] Comparative Study
Minimal Crossover between Mutations Associated with Omicron Variant of SARS-CoV-2 and CD8 + T-Cell Epitopes Identified in COVID-19 Convalescent IndividualsArticle Published on 2022-03-012023-06-17 Journal: mBio [Category] COVID19(2023년), MERS, SARS, [키워드] CD8+ T cell Convalescent patients convalescent plasma COVID-19 omicron SARS-CoV-2 [DOI] 10.1128/mbio.03617-21 PMC 바로가기
Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial중국 성인을 대상으로 한 SARS-CoV-2 ARCoV mRNA 백신의 안전성 및 면역원성: 무작위 배정, 이중 맹검, 위약 대조, 1상 시험Clinical Trial Published on 2022-03-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] abnormal change abnormal changes Academy administration adverse event adverse events Adverse reaction Adverse reactions All participant All participants analyses Analysis Anti-RBD IgG anti-SARS-CoV-2 Antibody titre assigned baseline block Block randomisation caused cellular immune responses China Chinese clinical testing conducted convalescent patient Convalescent patients COVID-19 pandemic development domain dose dose-escalation doses double-blind effective vaccine Effective vaccines eligible participant ELISA ELISPOT ENCODE enrolled enzyme enzyme-linked immunospot expected exploratory Fever first vaccination FIVE foundation grade 3 group groups highest hospital humoral humoral immune responses Humoral response humoral responses IFN-γ IL-2 immune immune response immune responses immunogenicity incidence individual Intramuscular injection investigators Laboratory laboratory analyses Laboratory test Laboratory tests live SARS-CoV-2 lowest majority Medical Science Medical Sciences Mild moderate mRNA vaccine natural neutralisation assays Neutralising Antibodies neutralising antibody observation outcome participant Participants peaked Phase 1 phase 1 trial Placebo placebo group placebo-controlled Primary outcome pseudovirus randomised Randomly RBD RBD IgG RBD-specific IgG receive Registered reported research and development resolved Safe Safety safety analyses safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses Science screened second dose second vaccination secondary outcome Serious Adverse Event Serious Adverse Events Seven significantly Specific Specific T-cell response Spike protein Support systemic adverse event T-cell Response T-cell responses the placebo group the SARS-CoV-2 titre titres Tolerability treatment allocation Trial vaccination Vaccine vaccine dose vaccine doses were assessed were given with COVID-19 Zhejiang [DOI] 10.1016/S2666-5247(21)00280-9 PMC 바로가기 [Article Type] Clinical Trial
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamstersB.1.427/1.429(엡실론) SARS-CoV-2 변종은 시리아 햄스터의 조상 B.1(614G)보다 더 치명적입니다.Research Article Published on 2022-02-102022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition airway airways Alpha animal models Antibody neutralization B.1 B.1.1.7 B.1.351 B.1.427 B.1.429 Beta body weight Body weight loss Brazil Clinical data convalescent patient Convalescent patients Critical determine dissemination Efficiency Epsilon evade experiments explain hamster hamsters help highest Human human population in vitro India Infection infections late stage lineages lung Lungs maintain moderate nasal Nasal cavity New observé oral swab oral swabs Oropharyngeal oropharynx P.1 P.2 parenchyma plasma pre-existing immunity recipients replicate Replication SARS-CoV-2 variant SARS-CoV-2 variants severe disease severe lung pathology sgRNA shown significant difference significant differences South Africa Spread susceptibility Transmissibility Transmission Vaccine Vaccine-induced immunity variant variants variants of SARS-CoV-2 Viral Viral RNA virulence virulent weight loss Zeta [DOI] 10.1371/journal.ppat.1009914 PMC 바로가기 [Article Type] Research Article
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemicOmicron 변이체는 항체 매개 중화에 대해 높은 내성을 보입니다: COVID-19 전염병 통제에 대한 시사점Article Published on 2022-02-032022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody BNT162b2 ChAdOx1 convalescent patient Convalescent patients COVID-19 pandemic Delta delta variant dominant dose evade Heterologous higher efficiency immune immune evasion immunization individual Infection Mutation neutralization of BNT162b2 omicron Omicron variant PROTECT raised remained SARS-CoV-2 severe disease Sotrovimab spike Spike protein Spread susceptible the SARS-CoV-2 therapeutic vaccination Vaccine variant Viral viral spike protein virus [DOI] 10.1016/j.cell.2021.12.032 PMC 바로가기 [Article Type] Article
Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection [DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology