Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell-cell fusion, and neutralization sensitivitySARS-CoV-2 변이체 B.1.617 분석: 숙주 친화성, 단백질 분해 활성화, 세포-세포 융합 및 중화 민감도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity Adenovirus adenovirus vaccine Amino acid B.1.617 caused cell-cell fusion cell–cell fusion cells Characteristics Convalescent patients COVID-19 pandemic D614G variant Delta escaped furin host tropism human cells immunized inactivated Inactivated vaccine India Infection Infectivity L452R mAbs Mutation mutations neutralization neutralization activities neutralization activity pathogenicity proteolytic activation pseudotyped Pseudotyped virus Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera T478K Transmissibility transmitted variant variants viruses volunteers [DOI] 10.1080/22221751.2022.2054369 PMC 바로가기 [Article Type] Article
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunityArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition amplified Antibody Response antigen expression attenuate B.1.351 B.1.617.2 Beta caused CD3 CD4 CD8 cell-mediated immune Cell-mediated immunity Cellular immune response Convalescent patients COVID-19 COVID-19 vaccine cytokine response Delta disease severity displaying dual-antigen saRNA vaccine elicit hamsters humoral immune response induce lower dose mice mRNA vaccine mutated N antigen Neutralizing antibody response Neutralizing antibody titer PROTECT Proteins RNA RNA vaccine S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants self-amplifying RNA spike T cell Th1 vaccination variant variants of concern Viral load [DOI] 10.1016/j.ymthe.2022.04.014 PMC 바로가기
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVIDArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute phase Antigen Appendix CD68 Convalescent patients COVID COVID-19 defined Diagnosis exhibited explained gastrointestinal tract Immune cell Immunocompromised patient immunohistochemistry individual Long COVID macrophage marker multiplex multiplex immunohistochemistry nucleocapsid protein occur Patient positive Post-acute COVID-19 syndrome raise reported residual SARS-CoV-2 RNA SARS-CoV-2 SARS-COV-2 infection Symptom symptom onset target the SARS-CoV-2 virus tissue tissues Viral antigen viral nucleocapsid protein viral persistence viral replication Viral RNA virus World Health Organization [DOI] 10.3389/fimmu.2022.939989 PMC 바로가기
Neutralizing activity to SARS-CoV-2 in 1.2 to 10.0 month convalescent plasma samples of COVID-19: A transversal surrogate in vitro study performed in Quito-EcuadorCOVID-19의 1.2~10.0개월 회복기 혈장 샘플에서 SARS-CoV-2에 대한 중화 활성: 키토-에콰도르에서 수행된 횡단 대리 시험관내 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyzed binding domain BSL2 facility BSL3 caused convalescence Convalescent patients convalescent plasma convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determine diagnostic methods Ecuador glycoprotein IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M in some in vitro study Infection NAb NAbs neutralization test Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody performed plasma positive presence or absence Quito remained reported respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus surrogate Test the SARS-CoV-2 Viral viral spike virus Wuhan Wuhan, China [DOI] 10.1002/jmv.27866 PMC 바로가기 [Article Type] Article
Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patientsArticle Published on 2022-08-272022-10-05 Journal: Cell Death & Disease [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute phase addition analyzed anti-S Anti-spike antibody-dependent cellular cytotoxicity Apoptosis apoptotic build CD4 T cell CD4 T-cell Cell contribute Convalescent patients coronavirus 2 correlated COVID-19 COVID-19 patient CXCL10 death demonstrated disease severity early phase help humoral IgA IgG IgG response IgM Immunoglobulin individual infected individual infected individuals Infection inflammatory reaction lymphopenia magnitude marker membrane neutralization pathogenicity Patient plasma predominant programmed cell death Proteins reducing reported respiratory response responses SARS-CoV-2 nucleocapsid soluble Fas ligand specific IgG antibodies T-cell the S protein [DOI] 10.1038/s41419-022-05190-0 [Article Type] Article
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단, [키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19 [DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
Humoral and cellular response in convalescent COVID-19 lupus patients회복기 COVID-19 루푸스 환자의 체액 및 세포 반응Article Published on 2022-08-122022-09-11 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] accumulated adaptive Analysis analyzed antibodies antibody Antibody Response Antibody titer Antibody titers CD8 cellular response changes in collected confirmed cases confirmed COVID-19 case convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients COVID-19 COVID-19 disease COVID-19 incidence COVID-19 infection COVID-19 susceptibility declined decrease died dose dysregulation evaluated flow cytometry Gene expression analysis General population Health care higher risk Hospital admission humoral Humoral and cellular responses hypocomplementemia IgG antibodies immune dysregulation immune response immunological immunological profile Immunological studies Immunosuppression immunosuppressive immunosuppressive therapy impair incidence increase in Infection intensive care lack longitudinal longitudinal changes Lupus medical record memory cell Mild Patient patients PBMC PBMCs PCR-confirmed COVID-19 Prednisone predominant prospective cohort reduction required risk factor Risk factors SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody severe COVID-19 disease severe disease severity Signaling SLE Surveillance susceptibility sustained Symptom symptom onset T cell Th17 Th2 response therapy were measured [DOI] 10.1038/s41598-022-17334-5 PMC 바로가기 [Article Type] Article
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope우성 SARS-CoV-2 킬러 T 세포 에피토프에서 면역 탈출의 출현Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen CD8 CD8 T cell Cohort cohorts convalescent patient Convalescent patients coronavirus COVID-19 dominant emergence epitope Epitopes for inclusion Frequency glycoprotein highlighting HLA human leukocyte antigen immune Immune escape individual leukocyte Lineage lineages mounted Mutation new SARS-CoV-2 Next generation vaccine next generation vaccines peptide-HLA Phylogenetic prevalent Protein response SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 spike SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus spike spike glycoprotein T cell T cell epitope T cell epitopes T cell receptors vaccine immunity variants viral escape Viral protein Viral proteins [DOI] 10.1016/j.cell.2022.07.002 PMC 바로가기 [Article Type] Article