Evaluation of Residual Infectivity after SARS-CoV-2 Aerosol Transmission in a Controlled Laboratory SettingArticle Published on 2021-10-242022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome aerosol Aerosols cell line clinical samples collected comparable Concentration condition conditions Contact Controlled coronavirus CPE cylindrical Cytopathic effect Dilution Efficiency in vitro Infectivity initial Laboratory molecular observation Particles post inoculation preventive measure quantification reported residual Residual infectivity Resilience Respiratory droplets RNA SARS-CoV-2 setting subject supernatant tested Transmission transmitted Transport Travel Vero E6 Viral load virus titer was determined was tested [DOI] 10.3390/ijerph182111172 PMC 바로가기 [Article Type] Article
Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care unit dedicated COVID-19Short Report Published on 2021-10-212022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] COVID-19, MERS, SARS, [키워드] absence Bacteria Carbapenemase Cluster Concomitant contributed COVID-19 COVID-19 patients CPE Cross transmission drug-resistant Enterobacter Enterobacter cloacae Factor highlight infection control intensive care intensive care unit measure nosocomial outbreak Patient Personal protective equipment Prevent SARS-CoV-2 supplementary material Transmission [DOI] 10.1186/s13756-021-01022-6 PMC 바로가기 [Article Type] Short Report
Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2Article Published on 2021-10-092022-10-04 Journal: Journal of virological methods [Category] MERS, SARS, 치료기술, 치료제, [키워드] accompany acute respiratory syndrome added African green monkey analyzed antibodies antibody concentration approach biosafety BSL-3 Cell cell line cells Colon cancer Combination common cold comparability complicate conducted coronavirus counter CPE Culture Cytopathic effect days post infection demonstrated described droplet fibroblast Flow virometry growth Growth Curve HCoV-OC43 human coronavirus human coronavirus OC43 human lung Improving Infection infectious dose investigated kidney less multiplicity of infection pandemic parameter Plaque assay produced quantification quantified reached reducing reproducibility required Research respiratory aerosol Respiratory system Sample SARS-CoV-2 Sartorius Seven Standardization target TCID these cell tissue transmitted Vero E6 Vero E6 cell virion virus particle Virus titration [DOI] 10.1016/j.jviromet.2021.114317 PMC 바로가기 [Article Type] Article
Development of the RealTime SARS-CoV-2 quantitative Laboratory Developed Test and correlation with viral culture as a measure of infectivityRealTime SARS-CoV-2 정량 연구실 개발 감염성 측정을 위한 검사 및 바이러스 배양과의 상관관계 개발Article Published on 2021-10-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott absence antiviral therapy Clinical use correlation CPE Culture demonstrated Developed development diagnosis of COVID-19 dynamic range Emergency use evaluated FDA Guidance highest implication individual inter- and intra-assay limit of detection log Lower molecular Nasopharyngeal swab nasopharyngeal swabs NPs public health Quantitative quarantine R 2 ranged reproducibility respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load Test vaccine trial Vero CCL81 cells Viral viral culture Viral load viral shedding virus was determined while [DOI] 10.1016/j.jcv.2021.104945 PMC 바로가기 [Article Type] Article
Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung CellsCommunication Published on 2021-09-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 229E acid added affected Antiviral antiviral activity Antiviral compound caused coronavirus Coronaviruses COVID-19 pandemic CPE Cytopathic effect deaths demonstrated disrupting Ebola effective effective antiviral treatment Efficacy epithelial Epstein Barr virus exhibited expression fusion inhibitor ginkgolic acid globe HCoV-229E Herpe HIV HSV-1 Human human coronavirus in vitro in vivo individual Infection influenza A inhibit inhibited inhibiting lung cell Post-infection progeny Proteins reduced reported SARS-CoV-2 significantly similarity strain Vaccine Viral mutations Viral protein Viral proteins virus production viruses [DOI] 10.3390/ph14100980 PMC 바로가기 [Article Type] Communication
Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic targetProlyl 이성질 효소 PIN1은 SARS-COV-2 증식에서 필수적인 역할을하며, 이는 새로운 치료 표적으로서의 가능성을 나타낸다.Article Published on 2021-09-172022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, [키워드] activate Acute promyelocytic leukemia acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added addition APL ATRA cells cellular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CPE Culture culture medium Cytopathic effect drug Drug development expression global pandemic Infectious diseases inhibit inhibitor inhibitory effect leukemia medium molecular mechanism mRNA mRNA synthesis N protein novel Novel coronavirus novel coronavirus disease PIN1 potential therapeutic agent potential therapeutic agents proliferation Promyelocytic leukemia protein synthesis receptor reduced respiratory retinoic acid SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus siRNA suppressed Target identification therapeutic agents therapeutic target Transcription treat Viral [DOI] 10.1038/s41598-021-97972-3 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVAArticle Published on 2021-09-012022-10-27 Journal: African Journal of Infectious Diseases [Category] COVID-19, [키워드] Sausseria lappa administration animal model Cellular immune response cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immunomodulator Indonesia lung marker material membrane protein mice Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Virological and genomic analysis of SARS-CoV-2 from a favipiravir clinical trial cohortfavipiravir 임상 시험 코호트에서 SARS-CoV-2의 바이러스 및 게놈 분석Randomized Controlled Trial Published on 2021-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 유전자 메커니즘, 임상, 치료제, [키워드] age China clade clinical study clinical trial Cohort collected conducted correlated CPE Cytopathic effect Daily disease onset distribution duration of symptoms Efficacy Europe Evidence evidence of examined Favipiravir followed by Genome Genome epidemiology genomes Genomic analysis hospital Japan majority Male sex median time Mutation nasopharyngeal specimen no evidence of one patient participated Patient pharmacotherapy randomization randomized clinical trial RdRP RdRp gene reducing reflected remained replacement reported RT-PCR SARS-CoV-2 SARS-CoV-2 genome sequenced significantly strain Strains the disease therapy Trial viability Viral load viral loads [DOI] 10.1016/j.jiac.2021.06.010 PMC 바로가기 [Article Type] Randomized Controlled Trial
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 DiseaseArticle Published on 2021-08-152022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 384-well plate Antiviral Cell culture complex conducted coronavirus Coronavirus infection COVID-19 COVID-19 hospitalization COVID-19 infection CPE cytotoxicity deaths dendrimers disease effective evaluate humans Hydroxychloroquine immune clearance in vitro individual infected patient Infection inhibit limit morpholinos MRCV-19 novel overlap Phase I pp1a Prevent pulmonary disease reduce reducing reduction Remdesivir Replication SARS-CoV-2 SARS-CoV-2 replication shown Support target the SARS-CoV-2 Toxicity translation translation initiation translational Vaccine viral burden Viral transmission [DOI] 10.3390/biomedicines9081018 PMC 바로가기 [Article Type] Article