Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell LevelCommentary Published on 2021-06-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] ACE2 Adults analyzed Cell cell type children Clinical symptoms construction COVID-19 COVID-19 infection CTSB CTSL explain expression level expression pattern Factor fetal FIVE global pandemic Host Human Infection Injury landscape Level mechanism MTHFD1 organ organs risk SARS-CoV-2 single-cell RNA-seq Symptoms symptoms of COVID-19 TMPRSS2 [DOI] 10.14336/AD.2021.0301 PMC 바로가기 [Article Type] Commentary
Genome‐wide screening of SARS‐CoV‐2 infection‐related genes based on the blood leukocytes sequencing data set of patients with COVID‐19Research Article Published on 2021-05-282022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome adverse effect Analysis analyzed AUC AUC value bioinformatics blood leukocyte calculated caused contribute coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CTSB CTSL DEGs Diagnosis diagnostic differentially expressed gene disease enrichment analysis Epidemic EPSTI1 expressed expression function Gene ontology GEO database Health IFI27 IFIT3 leukocyte Logistic regression analysis mechanism OASL Patient positively correlated Protein–protein interaction risk ROC Curve SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 screened sequencing data therapeutic therapeutic target TMPRSS2 Treatment USP18 virus XAF1 [DOI] 10.1002/jmv.27093 PMC 바로가기 [Article Type] Research Article
Susceptibility of neuroblastoma and glioblastoma cell lines to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 신경모세포종 및 교모세포종 세포주의 감수성Article Published on 2021-05-012022-09-11 Journal: Brain research [Category] SARS, 치료기술, [키워드] Analysis Apoptosis Cell cell line cell lines cell type cells Coronavirus-2 CTSB CTSL Cytopathic effect death demonstrated described downregulation epithelial cell epithelial cells Express Gene Expression Genes Glioblastoma Glutamate idea In situ hybridization infected cell infected cells Infection maintain MOI MOIs Neuroblastoma neuronal neurotropism Perspective quantification replicate retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 SH-SY5Y susceptibility tropism upregulation Vero E6 VERO E6 cells virus were expressed were infected [DOI] 10.1016/j.brainres.2021.147344 PMC 바로가기 [Article Type] Article
Genetic variability in COVID-19-related genes in the Brazilian populationArticle Published on 2021-04-022022-10-04 Journal: Human Genome Variation [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project 1KGP ABO ACE2 ACE2 gene Affect allele frequency Analysis analyzed angiotensin-converting enzyme 2 Brazil Brazilian Brazilians candidate gene CCR9 Clinical prognosis contribute country COVID-19 COVID-19 case COVID-19 infection COVID-19 patients COVID-19 severity CTSL CXCR6 database disease DQB1 DRB1 examined Exome exomes explain FYCO1 gene sequence genetic background genetic study genetic variability Genetic variation Genome gnomAD help highest HLA allele Host host cells human lung cells identify IL6 Immunity implicated individual individual level infect Infection infection with SARS-CoV-2 Influenza virus information International investigated life-threatening loci LZTFL1 nonsynonymous Other Patient Phase 3 Pneumonia Population predicted previous study Protein Rare variants rate of infection recent receptor recorded reported risk SARS-CoV-2 SARS-COV-2 infection Seven shown SLC6A20 suggested susceptibility therapeutic targets TMPRSS2 transmembrane serine protease type I interferon unique university Variability variant Variation viral infection XCR1 [DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development카텝신 L은 인간과 인간화 마우스에서 SARS-CoV-2 감염에 핵심적인 역할을 하며 신약 개발의 유망한 표적입니다Article Published on 2021-03-272022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 신약개발, 치료제, [키워드] amantadine anti-influenza drug cathepsin cathepsin L circulating cleaved COVID-19 CTSL disease course drug Drug screening elevated evidenced expression Human human ACE2 human cell human cells humanized in vitro in vivo Infection Infectious diseases inhibited inhibitor knockdown mice molecular basis overexpression patients with COVID-19 positively correlated prevented pseudovirus infection SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severity significantly Spike protein the SARS-CoV-2 transgenic mice turn virus entry [DOI] 10.1038/s41392-021-00558-8 PMC 바로가기 [Article Type] Article
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approachCOVID-19의 그럴듯한 치료를 위한 SARS-CoV-2에 대한 다중 표적 제제로서 천연 폴리페놀 카테킨 식별: 통합 컴퓨터 접근Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료법, [키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin anti-SARS-CoV-2 antiviral drug antiviral drugs approach binding affinity binding free energy binding pocket catechin cathepsin L caused chymotrypsin claimed coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 CTSL cysteine cysteine protease determined by development Disease progression drug enzyme free energy free energy landscape global pandemic glycoprotein hACE2 Host human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrophobic hydrophobic interactions identify identifying interactions involved molecular molecular dynamics Molecular dynamics simulation molecular interaction multi-targeted drug. non-structural protein NSP6 nucleocapsid protein pandemic Proteins RBD RdRP Replication RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 proteins Seven severe acute respiratory syndrome Coronavirus target protein target proteins the SARS-CoV-2 therapy Transmission Vaccine viral-host interaction Virtual screening virus [DOI] 10.1093/bib/bbaa378 PMC 바로가기 [Article Type] Article
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Research Published on 2021-03-022022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome age airway alveolar association Cell cells cellular entry coexpressed complement pathways contribute coronavirus coronavirus disease COVID-19 cross-talk CTSL demographics enzyme expression expression level expression pattern Factor gut tissue highlight immune function individuals interleukin-6 involved lung lung parenchyma males Meta-analysis molecular nasal nasal passages Necrosis other organ pathogenesis of COVID-19 pathology pathway performed protease respiratory epithelial cell SARS-CoV-2 SARS-CoV-2 entry secretory cell Sex Single-cell RNA-sequencing smoking subset therapeutic intervention tissue tissues TMPRSS2 Transmission viral entry viral tropism [DOI] 10.1038/s41591-020-01227-z [Article Type] Research
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection인간 난자, 접합자 및 배아는 중증 급성 호흡기 증후군 코로나바이러스 2 감염에 필요한 수용체 안지오텐신 1 전환 효소 2 및 막횡단 세린 프로테아제 2 단백질을 발현합니다Article Published on 2021-02-012022-09-11 Journal: F&S science [Category] SARS, 변종, 치료기술, [키워드] absence ACE2 ACE2 gene ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin assisted reproductive technology blastocyst cathepsin L CD147 Cell cells cellular center Chain Reaction clinical collected Combination coronavirus CTSL cumulus demonstrated disposition Embryo embryos entry receptor enzyme Express expressions follicular follicular cells gcs germinal vesicle granulosa Human human IVF in vitro In vitro fertilization in vivo Infection lack Medicine mRNA occur Oocyte oocytes oocytes and embryos outcome ovarian ovarian cells. ovulatory polymerase chain polymerase chain reaction positive Presence presence or absence protease Proteases Protein protein expression Quantitative receptor receptors reproductive Reproductive technology required Research respiratory reverse transcription Ribonucleic acid SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus susceptible the patient TMPRSS2 TMPRSS2 protein transcript transmembrane serine protease transmembrane serine protease 2 treated Treatment Trigger variant Vesicle virus western blotting women [DOI] 10.1016/j.xfss.2020.12.005 PMC 바로가기 [Article Type] Article
The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus MonkeysGenetics Published on 2021-01-182022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Analysis analyzed animal model association Brain BSG children coronavirus coronavirus 2 coronavirus disease correlated COVID-19 CTSB CTSL development developmental differential expression DPP4 dynamic endosomal protease evaluate exhibited expressed expression expression level feature help highest Immune cell infiltration Immunity incidence Infection livers lung Lungs mediator Mild moderate Monkey Neonate Neonates Other pandemic pathogenic Population populations Potential protease Protective reached receptor researcher respiratory Rhesus monkey SARS-CoV-2 SARS-CoV-2 receptor severe disease Spread stages susceptibility therapeutic strategy TMPRSS2 TMPRSS9 Transcriptome transmembrane serine protease TTSPs Type Variability [DOI] 10.3389/fgene.2020.607479 PMC 바로가기 [Article Type] Genetics
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytesSARS-CoV-2 진입 매개체는 심근세포가 우선적으로 풍부합니다.Research Published on 2021-01-042022-09-10 Journal: Hereditas [Category] 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding cardiac conduction cardiac injury cardiac muscle cathepsin B cathepsin L Cell cellular coronavirus disease Coronavirus disease 2019 cough COVID-19 CTSB CTSL DEGs differentially expressed gene Differentially expressed genes embryonic enrichment analysis expression Fever Injury ion channel less mechanism mediator mitochondrial muscle contraction Patient patients with COVID-19 priming protease Regulation respiratory respiratory chain respiratory symptom respiratory symptoms Result RNA expression S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2, COVID-19, ACE2, CTSB, CTSL, cardiac injury Serine serine protease Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Signaling single-cell Spread susceptible TMPRSS2 transmembrane serine protease ventricular Viral viral transcription [DOI] 10.1186/s41065-020-00168-4 PMC 바로가기 [Article Type] Research