Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL pro inhibitors for treating COVID-19COVID-19 치료를 위한 SARS-CoV-2 3CL pro 억제제로서의 9,10-디히드로페난트렌 유도체 발견Article Published on 2022-01-152022-09-11 Journal: European journal of medicinal chemistry [Category] 신약개발, 치료제, [키워드] 3CL pro 9,10-Dihydrophenanthrenes acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition binding mode binding modes caused chymotrypsin Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cysteine cysteine protease derivative derivatives docking drug target enzyme Epidemic gastrointestinal tract human liver Human plasma in viral inhibit SARS-CoV-2 inhibition activity inhibitor investigated Protein Replication SARS-CoV-2 SARS-CoV-2 3CL(pro) severe acute respiratory syndrome Coronavirus Spread stability Structure-activity relationships target tested the SARS-CoV-2 treating COVID-19 viral replication [DOI] 10.1016/j.ejmech.2021.114030 PMC 바로가기 [Article Type] Article
Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial SourcesReview Published on 2021-11-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3-chymotrypsin-like protease 3CLpro Antiviral Bacteria candidate caused Community Compound coronavirus 2 COVID-19 COVID-19 pandemic cysteine protease drug drug design drug target expand function fungi Health HIV protease inhibitor Host Infection information inhibitor inhibitors less microbial Modification nucleic acids nucleosides nucleotides Papain-like protease platform PLPro Potential protease Proteases Protein protein synthesis reported researcher resource respiratory RNA SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 proteases SARS-CoV-2 viral SARS-CoV2 Source Spread structures suggested the SARS-CoV-2 Transcription translation Treatment urgency virus virus replication while with COVID-19 [DOI] 10.3390/microorganisms9122481 PMC 바로가기 [Article Type] Review
Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallographyResearch Papers Published on 2021-11-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] 3CL Protease antivirals autocleavage binding C145A mutant catalytic Catalytic mechanism catalytic site complex COVID-19 cysteine protease defined driven by drug design drug target electron density enzyme–substrate complex Gln help in silico inactive induced M pro main protease mechanism mutant Mutation pandemic peptide protease reported Respiratory disease room-temperature X-ray crystallography SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 replication the SARS-CoV-2 understanding X-ray X-ray crystallography [DOI] 10.1107/S2052252521010113 PMC 바로가기 [Article Type] Research Papers
Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymesarticle Published on 2021-08-312024-09-01 Journal: Microbiological Research [Category] 말라리아, [키워드] Amoebiasis CRISPR-Cas cysteine protease Leishmaniasis malaria [Article Type] article
Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar luteaArticle Published on 2021-08-052022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] Nuphar 6,6′-dihydroxythiobinupharidine binding binding site biochemical catalytic cathepsin complexes condition covalent docking COVID-19 cysteine cysteine protease cysteine proteases demonstrated derivative determine disulfide bond docking docking results electrophilic inactive inhibition inhibitors Interaction lack M pro MPro mechanism molecular molecular dynamic simulation nucleophilic Nuphar performed reactivity SARS-CoV-2 shown specificity stability suggested supported tested [DOI] 10.3390/molecules26164743 PMC 바로가기 [Article Type] Article
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infectionSARS-CoV-2 감염을 표적으로 하는 3-키모트립신 유사 시스테인 프로테아제 억제제의 발견 및 개발에 대한 고려 사항Review Published on 2021-08-012022-09-11 Journal: Current opinion in virology [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro acting acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral Chymotrypsin-like protease Clinical efficacy Control coronavirus COVID-19 pandemic cysteine protease Hospitalized host protease host proteases in vitro inhalation inhibitor injection intrinsic issue oral bioavailability PF-07304814 PF-07321332 populations Predictive Predictive value protease SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 virus entry virus replication [DOI] 10.1016/j.coviro.2021.04.006 PMC 바로가기 [Article Type] Review
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19COVID-19에 대한 치료 전략으로 SARS-CoV-2 프로테아제를 표적화하기 위한 과제Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] MERS, SARS, 진단, 치료제, [키워드] antiviral potency cathepsin cathepsin cross-reactivity Cathepsins Cell cellular challenge Compound COVID-19 cysteine cysteine protease cysteine proteases determine effective inhibitor effort evaluated explained expressing expression focus highlight host cell identify infection assays inhibited inhibitor inhibitors lead lysosomal cathepsins M pro main protease Papain Papain-like protease potency Prevent produced protease Proteases purified reported SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 virus screened selectivity Serine Strategy targeting the SARS-CoV-2 virus TMPRSS2 transmembrane serine protease Treatment treatment of COVID-19 Viral viral entry viral entry pathway viral infectivity viral replication [DOI] 10.1021/acsinfecdis.0c00815 PMC 바로가기 [Article Type] Article
Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?감초의 항 바이러스 활동이 CovID-19 감염과 싸울 수 있습니까?Review Published on 2021-06-082022-09-10 Journal: Biomolecules [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory antioxidant effect antioxidant effects antiviral properties antiviral property Can can not Cell chymotrypsin clinical trials component components Compound coronavirus COVID-19 COVID-19 disease COVID-19 emergency cysteine cysteine protease docking study enoxolone excluded feature Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid glycyrrhizin Host in viral indicated interfere licorice liquorice membranes nonspecific pandemic pharmacological Replication reported SARS Coronavirus SARS-CoV-2 Serine Spike protein Spread supported the SARS-CoV-2 transmembrane serine protease Viral virus virus entry viruses [DOI] 10.3390/biom11060855 PMC 바로가기 [Article Type] Review
Plant-derived chemicals as potential inhibitors of SARS-CoV-2 main protease (6LU7), a virtual screening studySARS-CoV-2 주요 프로테아제(6LU7)의 잠재적 억제제로서의 식물 유래 화학물질, 가상 스크리닝 연구Comparative Study Published on 2021-06-012022-09-11 Journal: Phytotherapy research : PTR [Category] Coronavirus, SARS, 치료제, [키워드] 3CLpro 6LU7 active site active sites ADMET antiviral activity antiviral properties antiviral property binding energy caused Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 cysteine cysteine protease dataset deaths docking Ebola Emetine enzyme Ginkgolide HIV Infection inhibitor inhibitors inhibitors of SARS-CoV-2 Lopinavir Mezerein molecular molecular docking MPro nelfinavir pharmacological physicochemical property phytochemicals protease SARS-CoV-2 shown Taking target Tubocurarine Virtual screening viruses Vitexin was performed was selected was used were used Zika [DOI] 10.1002/ptr.7041 PMC 바로가기 [Article Type] Comparative Study
Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain DeubiquitinasesArticle Published on 2021-05-282022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] approach binding catalytic compounds coronavirus covalent docking crystal structures cysteine protease cysteine proteases cysteine residue deubiquitinase docking drug design DUB Dynamics effective drug indicate inhibitor Interaction interactions knowledge Ligand ligand-bound modeling molecular dynamics OTUB1 OTUB2 pandemic Papain-like protease parameter PLPro protease protocol reactivity Research SARS-CoV SARS-CoV-2 selective stability stimulated subsequent suppress the SARS-CoV-2 Tumor viral replication were used [DOI] 10.3390/biom11060802 PMC 바로가기 [Article Type] Article