The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolismArticle Published on 2020-10-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, [키워드] analyzed Biomarkers cell metabolism Control coordinator cytosine described Diagnosis diagnosis of SARS-CoV-2 diagnostic early diagnosis evaluated Evolution explained feasibility generate IMPROVE independent infected with SARS-CoV-2 Infection inflammatory signal involved knowledge mechanism metabolism metabolome metabolomic metabolomics microbiota multivariate model pathway Patient Perspective plasma metabolome predict prognostic biomarker SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient sensitivity Support targets the disease therapeutic Virology [DOI] 10.1038/s41598-020-73966-5 PMC 바로가기 [Article Type] Article
Translation-Associated Mutational U-Pressure in the First ORF of SARS-CoV-2 and Other CoronavirusesMicrobiology Published on 2020-09-222022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amino acid substitutions Analysis caused coronavirus Coronavirus infections Coronaviruses COVID-19 COVID-19 pandemic cytosine cytosine deamination Deamination degenerate Efficiency genomic RNA globe implication investigated knowledge MERS mutational pressure Non-synonymous nucleotide nucleotide mutation nucleotide mutations observation ORF ORF1a ORF1ab ORF1b Other question Replication residue RNA SARS SARS-CoV-2 sequence significantly higher synonymous translated translation treating COVID-19 uracil Vaccine Viral RNA virus Wuhan strain [DOI] 10.3389/fmicb.2020.559165 PMC 바로가기 [Article Type] Microbiology
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesisArticle Published on 2020-09-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] Achille acute respiratory syndrome Antiviral effect antiviral therapeutics candidate caused clinical trial complex Corona coronavirus Coronavirus-2 COVID-19 cytosine inhibitor insertion mechanism of action Mutagenesis Nsp12 nucleoside analogue nucleotide pandemic polymerase provoking Rapid RdRP SARS-CoV SARS-CoV-2 SARS-CoV-2 genome T-705 Treatment Viral diseases Viral proteins Viral RNA [DOI] 10.1038/s41467-020-18463-z PMC 바로가기 [Article Type] Article