Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID-19 deaths이탈리아에서 DPP4 억제제 사용은 COVID-19 사망자 중 당뇨병 유병률과 상관관계가 없습니다Article Published on 2021-01-012022-08-31 Journal: Diabetes research and clinical practice [Category] MERS, SARS, 바이오마커, [키워드] clinically coronavirus COVID-19 death deaths diabete diabetes dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 DPP4 inhibitors fatal COVID-19 Hypothesis inhibitor Italy Patient Prevalence progression SARS-CoV-2 [DOI] 10.1016/j.diabres.2020.108444 PMC 바로가기 [Article Type] Article
Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology잠재적인 SARS-CoV-2 수용체인 CD26을 연령 및 병리의 바이오마커로 조사Immunology & Inflammation Published on 2020-12-232022-08-31 Journal: Bioscience Reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] A significant reduction acute respiratory distress acute respiratory syndrome acute respiratory syndrome coronavirus age age-related dementia Analysis ARD bind binding Biomarker Blood blood clotting blood plasma blood smears cardiovascular disease CD26 Cell cells cellular cerebrospinal fluid Cluster cluster of differentiation collected Comorbidities controls Corona virus COVID-19 coronavirus Coronavirus-2 COVID-19 Covid-19 biomarker COVID-19 infection CSF Dementia diabetes Diabetes Mellitus differentiation dipeptidyl peptidase Dipeptidyl peptidase 4 dipeptidyl peptidase 4 (DPP4) DPP4 explain expressed glycoprotein help heterogeneity high risk host cell hypertension identify immune system in some individual individuals Infection Inflammatory inhibiting investigation leads membrane natural killer neutrophil pathology Platelet Platelets PROTECT receptor Regulatory reported respiratory respiratory distress risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serum serum sample serum samples subject subjects susceptibility Symptoms T-cell type 2 diabete Type 2 diabetes mellitus variety Viral viral entry viral infection virus [DOI] 10.1042/BSR20203092 PMC 바로가기 [Article Type] Immunology & Inflammation
[Homologous modeling and binding ability analysis of Spike protein after point mutation of severe acute respiratory syndrome coronavirus 2 to receptor proteins and potential antiviral drugs][심각한 급성 호흡기 증후군 코로나 바이러스 2의 수용체 단백질 및 잠재적 항바이러스 약물에 대한 점 돌연변이 후 스파이크 단백질의 상동 모델링 및 결합 능력 분석]Article Published on 2020-12-212022-09-11 Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe [Category] SARS, 변종, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity affinity binding Amino acid aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral aplaviroc APN AutoDock binding ability Bioinformatics analysis CD13 CD26 change Chimera Chinese conducted coronavirus dipeptidyl peptidase Dipeptidyl peptidase-4 docking DPP4 drug drug candidates drugs English enzyme evaluated Frequency functional glycoprotein greater HIV homologous host receptor Host receptors human cell human cells Human immunodeficiency virus human infection immunodeficiency immunodeficiency virus Infection molecular molecular docking simulation mutate mutated Mutation natural mutation natural mutations peptidase Point mutation PolyPhen-2 Protein protein structure receptor receptor protein respiratory S protein SARS-CoV-2 sequence Sequence alignment Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher small molecule spike spike glycoprotein Spike glycoprotein, coronavirus. Spike protein spontaneous mutation Taking the S protein Treatment unique virus was performed was used weakened ZDOCK [DOI] 10.19723/j.issn.1671-167X.2021.01.023 PMC 바로가기 [Article Type] Article
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue안지오텐신 전환 효소 2 및 레닌-안지오텐신 시스템 수용체의 기능적 복합체: 태아 폐 조직이 아닌 성인에서의 발현Article Published on 2020-12-162022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 activate acute respiratory syndrome alteration analogy angiotensin Angiotensin II angiotensin receptor Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding CAMP CD26 Cell cell entry chemokine Chemokine receptor cleave complexes component Coronaviruses COVID-19 CXCL12 CXCR4 dipeptidyl peptidase Dipeptidyl peptidase-4 downregulation energy transfer enzyme expression fetal G-protein highlight Human human ACE2 Human immunodeficiency virus immunodeficiency virus infect interact Interaction Ligand lung lung tissue Lungs macromolecular Mas receptor MAS1 mechanism membrane mitogen-activated protein kinase organs performed potential therapeutic targets Protein protein kinase RAS receptor receptors Renin renin-angiotensin system respiratory SARS-COV-2 infection SARS-CoV-2 receptor SDF-1 Severe acute respiratory syndrome Signal transduction Signaling System target cell target cells upregulation while [DOI] 10.3390/ijms21249602 PMC 바로가기 [Article Type] Article
Genetic mechanisms of critical illness in COVID-19 Research Published on 2020-12-012022-10-05 Journal: Nature [Category] 신약개발, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] Antiviral association caused CCR2 chemotactic chromosome Clinical practice coronavirus disease COVID-19 Critical Critically ill patient dipeptidyl peptidase drugs ENCODE enzyme activator Evidence expression gene cluster Genetic Genetic variant Genome-wide association study genome-wide significant GenOMICC Host identify IFNAR2 Inflammatory intensive care units life-threatening low expression Lung inflammation lung tissue mechanism mendelian randomization OAS1 OAS2 organ damage randomized clinical trial receptor replicated robust severe COVID-19 target the interferon therapeutic transcriptome-wide Treatment TYK2 tyrosine with COVID-19 [DOI] 10.1038/s41586-020-03065-y [Article Type] Research
A potential therapeutic combination for treatment of COVID-19: Synergistic effect of DPP4 and RAAS suppressionCOVID-19 치료를 위한 잠재적인 치료 조합: DPP4와 RAAS 억제의 시너지 효과Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] MERS, SARS, 바이오마커, 치료법, [키워드] ACE-2 addition adenosine adenosine deaminase Affect aldosterone angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Brain caused CD26 cell surface receptor cell surface receptors cells combating Combination component coronavirus coronavirus disease Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 patient diabetes dipeptidyl peptidase Dipeptidyl peptidase-4 disease DPP4 Elderly patient elderly patients enzyme global pandemic heart hypertension immune response implicated kidney Lower respiratory tract men Mortality multiple organs Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Protein RAAS receptor Regulation Renin renin-angiotensin-aldosterone system Renin–angiotensin–aldosterone system. respiratory SARS-CoV-2 suppression synergistic effect therapeutic therapeutic strategy Treatment [DOI] 10.1016/j.mehy.2020.110186 PMC 바로가기 [Article Type] Article
Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivoArticle Published on 2013-11-052024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] combination therapy dipeptidyl peptidase iron-mediated delivery targeted prodrugs.