DNA repair – Page 3 – Communicable Diseases Research

Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity

Research

Published on 2021-04-142022-10-29
Journal: Microbiome [Category] COVID-19, MERS, SARS,

[키워드] active viral replication Admission Affect age alteration association Asymptomatic Bacterial Blood Blood level blood specimen caused cells co-morbidities collected Control Coronavirus disease 2019 correlated COVID-19 COVID-19 cases COVID-19 patient COVID-19 severity Critical discharge disease disease course disease severity DNA DNA repair DNA virus DNA viruses enrolled eukaryotic explain fecal Fecal sample fecal samples gastrointestinal tracts Gender gene encoding Gut highlight Hospitalization Host host immunity Inclusion Inflammatory marker intestinal cells inverse correlation investigated Lineage metabolism Mild moderate Neutrophils Non-COVID-19 observation older subject outcomes parameters pathophysiology Patient pro-inflammatory Proteins regulate reported Result RNA RNA virus SARS-CoV-2 SARS-COV-2 infection sequenced Sequencing severity severity of COVID-19 specimen subject subjects supplementary material Temporal These viruses understanding unmet need virulence virus white cell with COVID-19
[DOI] 10.1186/s40168-021-01008-x PMC 바로가기 [Article Type] Research

Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccines

Review

Published on 2021-03-152022-10-28
Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, MERS, SARS,

[키워드] accessory protein Analysis antiviral effects cellular chemokine clinical symptom complexes coronavirus coronavirus strain COVID-19 COVID-19 patient Cytokines storm DNA repair domains driven by Effectiveness Evolution facilitate Factor Frame function functional Genome Genome sequences global pandemic help Host host cell host cells Immunity immunological resistance independent Inflammation inhibit innate immune cell interferon Lung injury mutated Mutation Non-synonymous ORF ORF1b Pathogenesis patients Perspective Protein provided receptor Recombination recruit Replication RNA RNA genome SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 vaccine specific mutation Spread strain structures suppress the spike protein translation understanding Vaccine Vaccines Viral RNA viral RNA synthesis virion virus virus entry Virus evolution virus infection
[DOI] 10.1590/1414-431X202010725 PMC 바로가기 [Article Type] Review

Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites

Article

Published on 2021-01-272022-10-04
Journal: Communications Biology [Category] 치료제,

Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites

표준 히스톤 H2A의 인산화가 말라리아 기생충에서 손상된 DNA의 초점을 표시한다.

Research Article

Published on 2021-01-132024-08-11
Journal: mSphere [Category] 말라리아,

[키워드] DNA damage DNA repair double-strand break H2A phosphorylation malaria Plasmodium falciparum
[DOI] 10.1128/mSphere.01131-20 PMC 바로가기 [Article Type] Research Article

A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections

Research Article

Published on 2021-01-062022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

[키워드] accelerate Analysis annealing Apoptosis apoptotic binding binding site Cell changes in competing complementary conserved death Dengue dengue virus described distribution DNA DNA damage DNA repair expected explain expression Genome H3N2 HIV-1 Host identify increasingly individuals induce infect infected patients influenza A Interaction Lung function molecular mechanism motif Multiorgan nuclear occur other tissues Pathogenesis pneumocyte Prevent proportion Protein pulmonary complication Pulmonary infection R-loop replication forks respiratory resulting RNA RNA binding protein RNAs RNPS1 SARS-CoV-2 SARS-CoV-2 replication sequence Significant SRSF1 strain Symptoms system failure transcript triggered viral genome viral genomes viral replication viral sequence viral sequences virion
[DOI] 10.12688/f1000research.25390.2 PMC 바로가기 [Article Type] Research Article

MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life

MRE11은 말라리아 기생충 전파에 필수적이며, 그 결여는 생명에 필수적인 주요 유전자들의 상호 연결된 네트워크 표현에 영향을 미친다.

Article

Published on 2020-12-032024-08-11
Journal: Cells [Category] 말라리아,

[키워드] DNA repair malaria MRE11 Plasmodium ribogenesis
[DOI] 10.3390/cells9122590 PMC 바로가기 [Article Type] Article

Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase

PfBlm의 DNA 수리 기능 설명 및 RecQ 헬리케이스의 소분자 억제제에 의한 아르테미시닌 작용의 강화

Research Article

Published on 2020-11-252024-08-11
Journal: mSphere [Category] 말라리아,

[키워드] DNA repair Homologous recombination molecular docking PfBlm PfWrn Plasmodium falciparum yeast complementation
[DOI] 10.1128/mSphere.00956-20 PMC 바로가기 [Article Type] Research Article

Use of Ultraviolet Blood Irradiation Against Viral Infections

Review Article

Published on 2020-10-072023-06-16
Journal: Clinical reviews in allergy & immunology [Category] MERS, SARS,

[키워드] antigen-presenting cells Blood cells Cytokines DNA repair UBI UV light viral infections
[DOI] 10.1007/s12016-020-08811-8 PMC 바로가기 [Article Type] Review Article

Vive la Différence: Exploiting the Differences between Rodent and Human Malarias

article

Published on 2020-06-302024-09-01
Journal: Trends in Parasitology [Category] 말라리아,

[키워드] chromatin differentiation DNA repair lipid metabolism Transcription
[Article Type] article

Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance

말라리아 기생충에 의한 숙주 특이성의 진화: 게놈 유지 관리를 조절하는 메커니즘의 변화

Article

Published on 2020-03-172024-08-11
Journal: mBio [Category] 말라리아,

[키워드] antigenic variation DNA repair Evolution malaria
[DOI] 10.1128/mBio.03272-19 PMC 바로가기