CIAO1 loss of function causes a neuromuscular disorder with compromise of nucleocytoplasmic Fe-S enzymesResearch Article Published on 2024-06-172024-09-05 Journal: The World Allergy Organization Journal [Category] update2024, [키워드] DNA repair Genetic diseases metabolism Muscle biology [DOI] 10.1172/JCI179559 PMC 바로가기 [Article Type] Research Article
ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesteraseResearch Article Published on 2024-05-142024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] binding protein conformational change Crystallography DNA repair Genomics inhibition mechanism phosphodiesterase: cancer RNA Small Angle X-ray Scattering (SAXS) structural biology [DOI] 10.1016/j.jbc.2024.107368 PMC 바로가기 [Article Type] Research Article
Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene TranscriptionReview Published on 2024-04-152024-09-05 Journal: Viruses [Category] update2024, [키워드] cccDNA DNA repair HBV Hepatitis B virus Viral hepatitis viral transcription [DOI] 10.3390/v16040609 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the DNA damage responseReviews Published on 2023-11-102024-09-05 Journal: Avicenna Journal of Medical Biotechnology [Category] update2024, [키워드] COVID-19 DNA damage response DNA repair SARS-CoV-2 senescence [DOI] 10.1099/jgv.0.001918 PMC 바로가기 [Article Type] Reviews
The mef(A)/ msr(D)-carrying streptococcal prophage Φ1207.3 encodes an SOS-like system, induced by UV-C light, responsible for increased survival and increased mutation ratemef(A)/msr(D)를 지닌 연쇄상구균 프로파지 Φ1207.3는 UV-C 빛에 의해 유도되는 SOS 유사 시스템을 인코딩하며, 이는 생존율 증가와 돌연변이율 증가에 책임이 있다.Article Published on 2023-09-262024-08-24 Journal: Retinal cases & brief reports [Category] 폐렴구균 감염증, [키워드] bacterial survival DNA repair fluctuation test mef(A)/msr(D) mutation rate prophage S. pneumoniae S. pyogenes SOS response UV-C LED light Φ1207.3.
Activities of endogenous APOBEC3s and uracil-DNA-glycosylase affect the hypermutation frequency of hepatitis B virus cccDNAArticle Published on 2022-04-012023-06-13 Journal: The Journal of General Virology [Category] B형 간염, [키워드] APOBEC DNA repair Hepatitis B virus Host factor Mutation [DOI] 10.1099/jgv.0.001732
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevitySirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다Review Published on 2022-03-012022-09-11 Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn [DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
CRISPR/Cas and Hepatitis B Therapy: Technological Advances and Practical BarriersReview Published on 2022-02-012023-06-11 Journal: Nucleic acid therapeutics [Category] [키워드] AAV base editing DNA repair double strand breaks Nuclease off-targets. [DOI] 10.1089/nat.2021.0075 [Article Type] Review
The potential role of COVID-19 in the induction of DNA damageDNA 손상 유도에서 COVID-19의 잠재적 역할Review Published on 2022-01-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting appearance Atherosclerosis Brain Cancer caused Cell cell cycle chronic disease Chronic diseases coronavirus coronavirus disease Coronavirus-2 Coronaviruses COVID-19 Cytokine storm syndrome death deregulation diabetes direct viral infection DNA DNA damage DNA repair DNA repair mechanism Effect Evidence evidence of genomic Health heart immunological in some individuals induce kidney kidneys Lungs mammalian cells mechanism multiorgan failure neurodegenerative disorders organs outcome Recovered COVID-19 patients recovered patient recovered patients Replication SARS-CoV-2 Sepsis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support Symptoms these viruses viral infection virus [DOI] 10.1016/j.mrrev.2022.108411 PMC 바로가기 [Article Type] Review