double-stranded – Page 3 – Communicable Diseases Research

Dynamics of the SARS-CoV-2 nucleoprotein N-terminal domain triggers RNA duplex destabilization

SARS-CoV-2 핵단백질 N-말단 도메인의 역학은 RNA 이중체 불안정화를 유발합니다

Article

Published on 2021-07-202022-09-11
Journal: Biophysical Journal [Category] SARS, 치료법,

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

Original Contribution

Published on 2021-07-052022-10-28
Journal: Basic Research in Cardiology [Category] COVID-19, Fulltext,

[키워드] ACE2 angiotensin-converting enzyme 2 B.1.1.7 B.1.351 caused Cell cellular distribution clearance Coronavirus disease 2019 COVID-19 direct infection double-stranded EDEM1 Effect Effects elevated endothelial Endothelial cell endothelial cells Endothelial dysfunction ER stress expressed Health higher risk highest Human in vitro Increased induce Infection Infectious virus Inflammation inoculated lung marker misfolded protein Mortality novel coronavirus SARS-CoV-2 P.2 Patient pro-inflammatory promote receptor reduced required responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant significantly higher Spike protein supernatant supplementary material susceptibility susceptible tested the SARS-CoV-2 the spike protein umbilical variant vascular bed Viral RNA viral spike protein virus infection virus replication Virus trapping wild type
[DOI] 10.1007/s00395-021-00882-8 PMC 바로가기 [Article Type] Original Contribution

Padlock probe-based rolling circle amplification lateral flow assay for point-of-need nucleic acid detection

필요 시점 핵산 검출을 위한 자물쇠 프로브 기반 롤링 서클 증폭 측면 유동 분석

Article

Published on 2021-06-282022-09-11
Journal: The Analyst [Category] SARS, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome amplification Analysis antimicrobial resistance Bacterial binding site biosafety can be used cleave complex complexity Culture diagnostics digestion DNA DNA and RNA double-stranded environmental monitoring Epidemiology faster food safety help inherent isothermal isothermal amplification method isothermal amplification methods lateral flow lateral flow immunoassay limit limit of detection linear NAAT Novel coronavirus Nuclease nucleic acid nucleic acid amplification tests Nucleic acid detection padlock pathogen Pathogens PCR plan platform polymerase probe provide RCA reaction referred to resistance gene respiratory robustness Rolling circle amplification Saliva SARS-CoV-2 sensitive Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 significantly single-stranded DNA targets Therapeutics tissue extract turnaround time water
[DOI] 10.1039/d1an00399b PMC 바로가기 [Article Type] Article

Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection

Article

Published on 2021-05-262022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] acute respiratory syndrome antiviral immunity AP-1 AP-1 family proteins caused Cell cellular chemokine cJUN and cFOS complex interaction coronavirus coronavirus disease Coronavirus infection COVID-19 Cytokine release syndrome demonstrated double-stranded eIF2α eIF2α epidemic diarrhea eukaryotic translation facilitate family highlighting IBV IBV-infected cells IL-6 IL-8 induce induction Infection Infectious Bronchitis Virus innate immune response integrated stress response interleukin-8 investigated life-threatening Local mRNA expression mutant overexpression pathway PKR Proinflammatory cytokine Protein Regulatory response SARS-CoV-2 Severe case significantly Stress unfolded protein response upregulation upstream virus
[DOI] 10.3390/ijms22115646 PMC 바로가기 [Article Type] Article

Genome-wide proximity between RNA polymerase and DNA topoisomerase I supports transcription in Streptococcus pneumoniae

RNA 폴리머라제와 DNA 토포이소머라제 I 사이의 게놈 차원의 근접성은 Streptococcus pneumoniae의 전사를 지원합니다

Research Article

Published on 2021-04-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증,

[키워드] addition Antibiotic resistance Antibiotics Bacteria binding clinically coding regions codon complex death determine develop disease distribution DNA DNA sequence DNA topoisomerase double-stranded Double-stranded DNA drug drug target effective enzyme Enzymes expression Factor functional Gene Expression Genes genome-wide association homeostasis in vitro in vivo indicate Interaction intergenic region intergenic regions Localization MACS mapped Meningitis molecular motif motifs Mycobacterium tuberculosis pair physically pneumococcal Pneumonia pneumoniae prevented promoter promoters Reactions recruit recruited regulate regulated Regulation Replication responsible rifampicin RNA polymerase RNAP Sepsis single-stranded Spread Streptococcus pneumoniae Support surface plasmon surface plasmon resonance target topoisomerase Topology transcript Transcription Treatment Tuberculosis Type type I
[DOI] 10.1371/journal.pgen.1009542 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes

423

Published on 2021-04-202022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] A549 ACE2 activate activated Activation alveolar antagonists Antiviral Calu-3 Cell cell lines cell types cells characterized consequence contribute Coronavirus infection COVID-19 disease COVID-19 pandemic Cytopathic effect Defense double-stranded dysregulated Effect Health Host host–virus interaction IFN IFN response IFN signaling induce infect inhibit initial innate immune innate immune response Interaction interferon interferon signaling genes Invasion knowledge lung; MAVS MERS-CoV Middle East mutant Nasal Epithelial cells OAS-RNase L other coronaviruses pathogenesis of SARS-CoV-2 pathway Pathways PKR Protein Replication response RNASEL SARS-CoV-2 severe COVID-19 disease Signaling Significance syndrome unique viral double-stranded RNA virus while
[DOI] 10.1073/pnas.2022643118 PMC 바로가기 [Article Type] 423

Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-κB p50 as the regulator of cytokine storm

사이토카인 폭풍의 조절자로서의 NF-κB p50의 엔트로피 구동 전기화학발광 초고감도 검출 전략

Article

Published on 2021-03-152022-09-11
Journal: Biosensors & bioelectronics [Category] SARS, 치료기술,

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

지질 방울은 SARS-CoV-2 복제 및 염증 매개체 생성을 촉진합니다

Research Article

Published on 2020-12-162022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법,

[키워드] addition Analysis Antiviral biosynthetic CD36 Cell cell death cellular metabolism complex component contribute COVID-19 COVID-19 pandemic COVID-19 patient demonstrated described develop disease donors double-stranded droplet effort electron microscopy energy homeostasis ENhance enzyme expression function homeostasis Host host cell host cells host immunity human cell lines infected cells Infection Inflammation inflammatory mediator inhibited LDs Lipid lipid droplet lipid droplets lipid metabolism mechanism mediator mediators metabolism modulate modulation monocyte Monocytes organelle parasite Pathogenesis pathway Pathways Perspective pharmacological platform PPARγ pro-inflammatory response Protein recruit recruited reduce reduced Regulation Replication RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 replication SARS-CoV2 SARS-CoV2 infection significantly Support target therapeutic intervention Therapeutic strategies therapeutic strategy Transport triggered Vero Cell Vero cells Viral viral particle Viral particles viral replication virus virus replication viruses
[DOI] 10.1371/journal.ppat.1009127 PMC 바로가기 [Article Type] Research Article

Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA

Research

Published on 2020-12-032022-10-05
Journal: Nature biomedical engineering [Category] SARS, 임상, 진단, 치료기술, 치료제,

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

SARS-CoV-2는 인간 심근세포를 감염시키고 세포독성 효과를 유도합니다

Article

Published on 2020-12-012022-09-11
Journal: Cardiovascular Research [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Apoptosis blocked Caco-2 cardiac injury cardiomyocyte Cardiosphere Cardiotoxicity cathepsin cathepsin-dependent Cathepsins caused cell lines Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic effect demonstrated dependent on direct infection double-stranded Effect elevated enzyme expression global pandemic glycoprotein heart Heart slice higher risk in vitro Increasing induce infect Infection infection with SARS-CoV-2 infections Inflammation inhibited Injury interferon lead Lung injury marker Mortality oxygen Particle pathway Pathways Patient reactive oxygen Remdesivir respiratory RNA sequencing SARS-CoV-2 SARS-COV-2 infection secondary to severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein strain Stress supernatant supernatants tissue transcriptional response up-regulation Viral viral infection viral particle Viral particles Viral RNA viral spike viral spike protein
[DOI] 10.1093/cvr/cvaa267 PMC 바로가기 [Article Type] Article