Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug InteractionsCOVID-19에 대한 조사 치료는 약물 상호 작용을 통해 심실 부정맥 위험을 증가시킬 수 있습니다Article Published on 2021-02-012022-09-11 Journal: CPT: pharmacometrics & systems pharmacology [Category] 치료제, [키워드] action potential Analysis Arrhythmias Azithromycin cardiac adverse event cardiac adverse events cardiac electrophysiology caused cellular Chloroquine Combination combination therapy coronavirus disease Coronavirus disease 2019 COVID-19 disease drug drug combination drug combinations Drug interactions drugs Effect Factor greater healthy individual healthy individuals heart disease heart failure increase Isolation lead Lopinavir mathematical men molecular Myocyte Patient patient group pharmacokinetics potential benefits predict predicted QT prolongation Quantitative reported risk Ritonavir Sex Simulation statistical analysis susceptible Therapies treat Treatment ventricular ventricular arrhythmias women [DOI] 10.1002/psp4.12573 PMC 바로가기 [Article Type] Article
COVID-19 drug repurposing: A review of computational screening methods, clinical trials, and protein interaction assaysCOVID-19 약물 용도 변경: 컴퓨터 스크리닝 방법, 임상 시험 및 단백질 상호 작용 분석에 대한 검토Review Published on 2021-01-012022-08-31 Journal: Medicinal research reviews [Category] 신약개발, 임상, [키워드] clinical trial clinical trials Clinicians computational research coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment creation drug drug combinations Drug development Drug discovery Drug repurposing effective Efficacy experiments facilitate globe groups in vitro in vitro protein interaction assay. information Interaction mechanism organized pandemic pharmaceutical industry Protein Providing Research researcher screening methods situation the disease therapeutic Treatment [DOI] 10.1002/med.21728 PMC 바로가기 [Article Type] Review
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infectionTMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다Research Article Published on 2020-12-082022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS, [키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry [DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article
Peg-interferon and nucleos(t)ide analogue combination at inception of antiviral therapy improves both anti-HBV efficacy and long-term survival among HBV DNA-positive hepatocellular carcinoma patients after hepatectomy/ablationRandomized Controlled Trial Published on 2020-04-012023-06-13 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] drug combinations Hepatitis B virus Hepatocellular carcinoma interferon Prognosis [DOI] 10.1111/jvh.13236 [Article Type] Randomized Controlled Trial
Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malariaarticle Published on 2015-05-312024-09-01 Journal: Parasitology [Category] 말라리아, [키워드] drug combinations [Article Type] article