Chronische Hepatitis-B-Virusinfektion: aktuelle und zukünftige TherapieansätzeArticle Published on 2022-01-132023-06-02 Journal: Bundesgesundheitsblatt, Gesundheitsforschung, Gesu [Category] B형 간염, [키워드] Direct-acting antivirals (DAAs) Direkt antiviral wirksame Agenzien (DAA) Eintrittsinhibitor Entry inhibitor Hepatitis B virus (HBV) Hepatitis-B-Virus (HBV) Immunotherapy Immuntherapie Therapeutic vaccination Therapeutische Vakzinierung [DOI] 10.1007/s00103-021-03483-x PMC 바로가기
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein조작된 ACE2-IgG4-Fc 융합 단백질에 의한 우려되는 SARS-CoV-2 변이체의 피코몰 억제Article Published on 2021-12-012022-09-11 Journal: Antiviral Research [Category] SARS, 변종, 진단, 치료제, [키워드] ACE2 Activation Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody-dependent cellular cytotoxicity Antiviral antiviral drug antiviral therapy Beta binding Concentration COVID-19 delta variant ectodomain Entry inhibitor enzymatic activity fusing fusion protein host cell host cells human immunoglobulin human immunoglobulin G IgG IgG4 Immunoglobulin Immunoglobulin G in vivo inhibited limit maintain neutralize overcome pandemic Pandemics receptor Receptor trap. risk SARS-CoV SARS-CoV-2 SARS-CoV-2 variant spike glycoprotein therapeutic therapeutic antibodies therapeutic use TRAP variants variants of concern virus [DOI] 10.1016/j.antiviral.2021.105197 PMC 바로가기 [Article Type] Article
[Study of the inhibitory effect of cell entry inhibitory ezetimibe on hepatitis B virus in vitro]Article Published on 2021-11-202023-06-10 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] Entry inhibitor Ezetimibe Hepatitis B virus In vitro infection model. [DOI] 10.3760/cma.j.cn501113-20201204-00641
Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCPArticle Published on 2021-11-012023-06-12 Journal: Antiviral Research [Category] B형 간염, [키워드] Entry inhibitor ergosterol peroxide HBsAg Hepatitis B virus NTCP [DOI] 10.1016/j.antiviral.2021.105184
Identification of nut protein-derived peptides against SARS-CoV-2 spike protein and main proteaseSARS-CoV-2 스파이크 단백질 및 메인 프로테아제에 대한 견과류 단백질 유래 펩타이드 동정Article Published on 2021-11-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] addition Amino acid amino acid residue amino acid residues assist binding affinities binding affinity binding site coronavirus coronavirus disease COVID-19 COVID-19 patients develop domain effective Entry inhibitor entry inhibitors evaluated exhibited identification in silico inhibitor inhibitor N3 inhibitory M pro molecular docking molecular dynamics Molecular dynamics simulation Novel coronavirus novel coronavirus disease Nut proteins outbreak pandemic peanuts peptide peptides proportions protease Protein RBD reached SARS-CoV-2 SARS-COV-2 M(pro) SARS-CoV-2 main protease SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD SARS-CoV-2 spike RBD. screened Spike protein target the SARS-CoV-2 the spike protein Treatment [DOI] 10.1016/j.compbiomed.2021.104937 PMC 바로가기 [Article Type] Article
Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in WoodchucksArticle Published on 2021-09-052023-06-03 Journal: Cells [Category] B형 간염, Fulltext, [키워드] antiviral efficacy Chronic Hepatitis B Entry inhibitor Hepatitis B virus humanized antibody hzVSF Liver inflammation Safety Tenofovir alafenamide fumarate vimentin Woodchuck [DOI] 10.3390/cells10092321 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoidsResearch Published on 2021-08-052022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abietane diterpenes: Molecular docking ACE2 ACE2 binding African binding binding free energy catalytic Clustering analysis COVID-19 pandemic docked docking drug drug-likeness eight Entry inhibitor first stage hotspot human Angiotensin-converting enzyme in silico in vitro in vivo inhibiting inhibitory Interaction interactions MD simulation MERS-CoV molecular molecular docking analysis pentacyclic performed plant preserved protease Protein protein targets Proteins provide residue Result S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 spike protein screened serine 2 Spike protein stability supplementary material targeting targets terpenoids the RBD the SARS-CoV-2 therapeutic strategy TMPRSS2 trajectory transmembrane viral cell [DOI] 10.1186/s43141-021-00209-z PMC 바로가기 [Article Type] Research
Identification of SARS-CoV-2 entry inhibitors among already approved drugs이미 승인 된 약물 중 SARS-COV-2 진입 억제제의 확인Article Published on 2021-08-012022-08-31 Journal: Acta pharmacologica Sinica [Category] SARS, 신약개발, 치료제, [키워드] Amiodarone antagonist approved approved drug approved drug library approved drugs azelastine bosutinib clemastine clinical investigation clinically COVID-19 COVID-19 treatment drug drug library effective drug effective drugs Entry inhibitor flupenthixol high throughput screening assay Histamine histamine receptor histamine receptor antagonists identification in vivo inhibited inhibitor inhibitors molecular Pseudotyped virus pseudovirus entry receptor reducing Replication SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virus SARS2 screened significantly supernatant toremifene Treatment trimeprazine Vero E6 Vero E6 cell VERO E6 cells Viral viral RNA load virus entry virus entry inhibitors. [DOI] 10.1038/s41401-020-00556-6 PMC 바로가기 [Article Type] Article
New therapies for hepatitis delta virus infectionReview Published on 2021-06-012023-06-12 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] Direct-acting antivirals Entry inhibitor interferons prenylation inhibitors. [DOI] 10.1111/liv.14838 [Article Type] Review
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodiesArticle Published on 2021-04-292022-10-06 Journal: Cell [Category] SARS, 진단, [키워드] Alter antibodies antibody B.1.1.7 B.1.351 bamlanivimab blockade Brazil camostat Casirivimab cell interaction convalescent COVID-19 patient COVID-19 COVID-19 pandemic effort Entry inhibitor escape health system host cell Host cell entry human cell implication individuals inhibited inhibitor less Mutation neutralization neutralizing antibody neutralizing antibody responses P.1 P.1 variant pandemic plasma Protein pseudoparticles recombinant SARS-CoV-2 SARS-CoV-2 variant sera soluble ACE2 South Africa Spike protein Spread susceptible Treatment variant variants variants of concern viral spike VoC [DOI] 10.1016/j.cell.2021.03.036 PMC 바로가기 [Article Type] Article