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[키워드] ACE2 ACE2 expression Activation adverse effect adverse effects Affect alveolar alveolar epithelial cell Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Apoptosis Aspirin bind blunt bradykinin calcium Calcium signaling caspase cause caused Cell Cell signaling cells Coagulopathies complex Concentration contribute contributing to COVID-19 COVID-19 disease decreased expression downregulation dysfunction Effect Endothelial cell endothelial cells Endothelial dysfunction enzymatic activity enzyme epithelial epithelial cells event Evidence exposure expressed Factor homeostasis immunofluorescence microscopy in vitro model increased expression indicated infects Inflammation Interaction Interference Intervention Krüppel limit lung lung tissue lung tissues Lungs mechanism molecules organ dysfunction Pathogenesis pathology primary human cells pro-inflammatory molecules rationale receptor reduce reduced Respiratory function SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection Signaling significantly spike Spike protein suggested tested these cell These cells thought thrombotic Thrombotic events understanding uninfected Vascular viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article