A GMR enzymatic assay for quantifying nuclease and peptidase activityarticle Published on 2024-03-132024-09-05 Journal: Frontiers in Bioengineering and Biotechnology [Category] update2024, [키워드] disease monitoring DNA substrate enzymatic activity giant magnetoresistive sensor GMR peptide substrate point-of-care testing [DOI] 10.3389/fbioe.2024.1363186 PMC 바로가기 [Article Type] article
The Conservation and Study of Macromycetes in the Komarov Botanical Institute Basidiomycetes Culture Collection—Their Taxonomical Diversity and Biotechnological ProspectsArticle Published on 2023-12-142024-09-05 Journal: Journal of Fungi [Category] update2024, [키워드] culture collections enzymatic activity fungal biodiversity fungal lipids fungal strains oxidases secondary metabolites [DOI] 10.3390/jof9121196 PMC 바로가기 [Article Type] Article
Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samplesArticle Published on 2022-10-262022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 3CLpro acute respiratory syndrome applicability approach Asymptomatic individuals carried caused clinical test coronavirus death detect enzymatic activity enzyme Infection marker PCR testing pH indicator platform point-of-care proteolytic proteolytic activity reliability Saliva SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity subject Transmission Viral transmission [DOI] 10.1038/s41467-022-34074-2 PMC 바로가기
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10Short communication Published on 2022-10-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis Antiviral agents binding binding energy calculated Candidates complexes Compound COVID-19 docking enzymatic activity global pandemic inhibitor Interaction molecular dynamics Molecular dynamics simulation natural antiviral New nsp10 Protein RNA replication SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral selected stimulate suggested Vaccine Vaccine development Variation Virtual screening was performed ZINC database [DOI] 10.1016/j.bbrc.2022.08.029 [Article Type] Short communication
Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19Research article Published on 2022-08-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 바이오마커, 치료기술, [키워드] ACE ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Analysis Ang II angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors blockade cause circulating control group coronavirus COVID-19 COVID-19 group COVID-19 patient COVID-19 patients enzymatic activity etiological agent healthy healthy subjects Hospitalized hypertension hypertensive hypertensive patient investigated medications normotensive not different Patient patients protein level RAS receptor remained renin-angiotensin system reported Result significantly Support treated Treatment were excluded were measured with COVID-19 [DOI] 10.1016/j.biopha.2022.113201 [Article Type] Research article
Protein sensors combining both on-and-off model for antibody homogeneous assay항체 균질 분석을 위한 온/오프 모델을 결합한 단백질 센서Article Published on 2022-08-012022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] albumin antibodies antibody Antibody test assays binding biosensor changes in clinical samples Combination core protein Critical demonstrated enzymatic activity enzyme FLAG gp41 HCV hepatitis C hepatitis C virus high signal HIV homogeneous Homogeneous assay Human immunodeficiency virus Human serum albumin immunodeficiency virus individuals NanoLuc phenomenon potential tool potential tools Protein Protein switch. respond SARS-CoV-2-specific antibodies sensor serum serum sample serum samples signal-to-noise ratio specific antibodies working model [DOI] 10.1016/j.bios.2022.114226 PMC 바로가기 [Article Type] Article
Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLproSARS-CoV-2 Papain-like Protease PLpro용 유전적으로 인코딩된 형광 센서Article Published on 2022-07-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acceptor Biliverdin Cell cleavage co-expression coronavirus COVID-19 detect Donor downstream Endoplasmic reticulum energy transfer enzymatic activity fluorescence intensity fluorescent fluorescent protein FRET genetically encoded probes HeLa cells increase in inhibitors lifecycle linker live cell live cell imaging live cells membrane mNeonGreen non-structural protein non-structural proteins nsp1 NSP2 Nsp3 Papain Papain-like protease PLPro polyprotein protease protease PLpro Protein SARS-CoV-2 SARS-CoV-2 propagation sensor separated Stage the SARS-CoV-2 translocation [DOI] 10.3390/ijms23147826 PMC 바로가기 [Article Type] Article
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizerCOVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus [DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article
Herbal inhibitors of SARS-CoV-2 M pro effectively ameliorate acute lung injury in miceSARS-CoV-2 M pro의 허브 억제제는 쥐의 급성 폐 손상을 효과적으로 개선합니다Article Published on 2022-06-012022-09-11 Journal: Iubmb Life [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ALI/ARDS Anti-inflammatory ARDS bacterial lipopolysaccharide cell death China Chinese Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 patients distress effective effective drug effective drugs enzymatic activity functions Herbal identify in vitro in vivo Infectious disease Inhibition assays inhibitors of SARS-CoV-2 lipopolysaccharides Lung injury M pro mice MPro pan-anti-inflammatory protease respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread surface plasmon surface plasmon resonance syndrome the disease Traditional Chinese medicine treating COVID-19 patient Virtual screening virus [DOI] 10.1002/iub.2616 PMC 바로가기 [Article Type] Article
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article