Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기
Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical ExposuresCOVID-19 위험과 환경 화학 물질 노출의 교차점에서의 후성 유전학Review Published on 2022-09-012022-09-11 Journal: Current environmental health reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter among others Chemical contaminant COVID-19 COVID-19 susceptibility disease disrupting Drawing Endocrine Environmental chemicals Epigenetic epigenetic modification epigenetics Evidence exposure host antiviral responses host response immune pathway immune system Immunity Immunologic memory immunomodulation implicated include Infectious disease Inflammation Intersection involved mechanism memory Modification molecular mechanism Numerous Pathways recent Recognition Regulation risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity Specific susceptibility the SARS-CoV-2 virus viral entry [DOI] 10.1007/s40572-022-00353-9 PMC 바로가기 [Article Type] Review
How does age determine the development of human immune-mediated arthritis? Reviews Published on 2022-08-102022-10-05 Journal: Nature reviews. Rheumatology [Category] 유전자 메커니즘, 진단, [키워드] Adults Affect age Arthritis autoantibody children chronic inflammation contribute controls Critical determine develop disease driven by Drivers environmental exposure Epigenetic expand facilitate Factor Factors Genetic genetics hypothese immune immune system immune tolerance Immune-mediated individual Inflammation involved juvenile idiopathic arthritis maturation mechanism mechanisms microbial modulation Numerous Pathogenesis Patient Phenotypes pro-inflammatory similarity tolerogenic [DOI] 10.1038/s41584-022-00814-3 [Article Type] Reviews
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5 Research Published on 2022-08-012022-10-05 Journal: Nature cancer [Category] 변종, [키워드] Activation ACVR1 antitumor efficacy BMP CHRDL1 Clinical data CXXC5 disease Effect Epigenetic feature Impact implicated incurable intrinsic Ligand ligands Mutation Pathogenesis positive promote Protein regulate Regulation Signaling signaling pathway Tumor tumor cell tumor suppressor wild-type [DOI] 10.1038/s43018-022-00408-8 [Article Type] Research
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
Epigenetic mechanisms regulate sex-specific bias in disease manifestations후성 유전적 메커니즘은 질병 발현에서 성별에 따른 편향을 조절합니다Review Published on 2022-08-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] 유전자 메커니즘, [키워드] affecting Anatomy Autoimmune disorders Cancer change chromosome Clinical outcome clinical study COVID-19 COVID-19 infection differential expression disease disease manifestation disease onset Diseases Effect Epigenetic epigenetic modification epigenetics exhibit explained expression fibrosis Genes Genetic Genetic and epigenetic changes Hormones immune response immune responses immune system implicated inactivation infections input involved Liver fibrosis mechanism Neuropsychiatric Neuropsychiatric diseases progression recent regulate Respiratory disease respiratory diseases response to therapy responsible Sex Sex bias Sex chromosome sex hormone Sex hormones susceptibility therapeutic targets therapy underlying disease X chromosome X-inactivation X-linked X-linked gene X-linked genes. [DOI] 10.1007/s00109-022-02227-x PMC 바로가기 [Article Type] Review
Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden Research Published on 2022-07-252022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] activated Affect age Analysis Cancer changes in characterization Cohort Combination deficiency DNA DNA methylation Effect EpiC Epigenetic expression Factor Factors Genome Health healthy healthy individual human monocytes Illumina IMPROVE individual investigated involved knowledge marker medication Mental Methylation molecular Numerous occur Older pathway Pathways performed physical activity Prevalence Regulation shown SLC25A24 study cohort study participant Treatment Vitamin D Vitamin D receptor Vitamin D supplementation Wnt pathway [DOI] 10.1038/s41598-022-15924-x [Article Type] Research
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절Review Published on 2022-07-232022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법, [키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus [DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the NucleusSARS-CoV-2와 핵Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] blocked caused cells cilia Clinical studies contribute COVID-19 pandemic Critical cytoplasm DNA DNA damage Epigenetic epigenetics Genome greatly reduce immune responses inhibitor innate immune responses Innate immunity lack life cycle mechanisms metabolism mRNA metabolism nuclear nuclear translocation nuclear transport. nucleus other coronavirus other coronaviruses pathway Pathways pharmacological Regulation replicated RNA virus rupture SARS-CoV-2 small molecule small molecule drug small molecule drugs Therapeutic treatment Transport virus infection virus replication [DOI] 10.7150/ijbs.72482 PMC 바로가기 [Article Type] Review