SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures시험관내 항SARS-CoV-2 활성에 대한 고처리량 스크리닝 분석의 개발 및 최적화: 5676 1상 통과 구조 평가Clinical Trial Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African green monkey anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral Antiviral agents Caco-2 can not cell lines Chloroquine clinical development clinical trials clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 treatment development Doxorubicin drug effective enhanced green fluorescent protein epithelial cell epithelial cells expressing fluorescent green fluorescent protein green monkey Hydroxychloroquine in vitro inhibitor inhibitors itraconazole kidney library nelfinavir outbreak pandemic pharmacokinetic data Phase 1 Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection strain Strains Structure Support these compound these compounds Toxicity Treatment Vaccine Vaccines VeroE6-eGFP cells virus was used [DOI] 10.1002/jmv.27683 PMC 바로가기 [Article Type] Clinical Trial
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19숙주 키티나제 3-유사-1은 COVID-19의 SARS-CoV-2 바이러스 변이체에 대한 보편적인 치료 표적입니다Article Published on 2022-06-232022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] accumulate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha anti-CHI3L1 antibody Antibody neutralization Beta breakthrough infections caused Cell CHI3L1 chitinase Concentration coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 defined Delta delta variant demonstrated determine effective inhibitor epithelial epithelial cell Express FRG genetic variability host tissue induce Infection Infectious disease inhibit inhibitor Intervention kasugamycin Laboratory lethal disease Microbiology morbidity and mortality neutralization omicron priming protease pseudovirus pseudoviruses S protein SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease spike stimulate strain susceptibility the disease therapeutic target Therapeutics Transmissibility variant variants variants of concern viral variant viruses VoC Waves worldwide pandemic [DOI] 10.7554/eLife.78273 PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Ursodeoxycholic acid ameliorates cell migration retarded by the SARS-CoV-2 spike protein in BEAS-2B human bronchial epithelial cellsUrsodeoxycholic acid는 BEAS-2B 인간 기관지 상피 세포에서 SARS-CoV-2 스파이크 단백질에 의해 지연된 세포 이동을 개선합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression airway analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 basal layer BEAS-2B Beas-2B bronchial epithelial cell BEAS-2B cell Beas-2B cells binding bronchial epithelial cell caused Cell Cell migration cell proliferation cells changes in conditions contribute control cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damage damaged differentiation DNA ENhance enzyme epithelial epithelial cell flow cytometry followed by Gene Expression greater HEK293T Hela immunostaining inhibitory Interaction investigated mechanism Migration overexpression Plasmid Prevent Protective RBD receptor Receptor-binding domain reduced repair repair mechanism Repair mechanisms restoration restored RT-PCR SARS- CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Single Cell SP binding Spike protein syndrome the receptor-binding domain the SARS-CoV-2 the spike protein transfection Treatment Ursodeoxycholic acid Ursodeoxycholic acid (UDCA). virus infection was increased was measured western blotting wound healing [DOI] 10.1016/j.biopha.2022.113021 PMC 바로가기 [Article Type] Article
Lysozyme Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Inflammation in Human Corneal Epithelial Cells리소자임은 인간 각막 상피 세포의 중증 급성 호흡기 증후군 코로나바이러스 2 감염 및 염증으로부터 보호합니다Article Published on 2022-06-012022-09-11 Journal: Investigative ophthalmology & visual science [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry Cell toxicity characterized Corneal coronavirus coronavirus 2 Effect entry of SARS-CoV-2 enzyme epithelial cell epithelial cells expressed expression Human IL-6 Infection Inflammatory cytokine Inflammatory response luciferase lysozyme MCP-1 Pathogens pro-inflammatory molecule pro-inflammatory molecules proinflammatory molecule proinflammatory molecules PROTECT protective effect Protective effects pseudotyped respiratory robust RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection secretion Serine Spike protein Spike proteins stimulated suggested susceptibility tears TMPRSS2 TNF-α Toxicity transmembrane serine protease was measured was tested western blotting [DOI] 10.1167/iovs.63.6.16 PMC 바로가기 [Article Type] Article
Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational studyCOVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Pathology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology [DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study
Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patients with COVID-19 and MIS-C: Relation to the disease outcomeCOVID-19 및 MIS-C가 있는 이집트 소아 환자의 인터루킨(IL)-17A 및 IL-22의 상향 조절된 혈청 수준: 질병 결과와의 관계Article Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age ALT antimicrobial peptide antimicrobial peptides ARDS cellular children contribute COVID-19 CRP D-dimer died dimer elevated ELISA epithelial cell epithelial cells ferritin healthy control IL-17A IL-22 Increased infections Inflammatory Inflammatory marker inflammatory markers Interleukins LDH Level lymphopenia MIS-C MIS–C neutropenia neutrophilia not correlated outcome pathology Pathways Patient patients patients with COVID-19 patients with SARS-CoV-2 Pediatric patient peptides Protective relation Sample size SARS-CoV-2 serum serum ferritin level Serum level serum levels signaling pathways significantly higher stimulate syndrome synergistic synergistic action the disease thrombocytopenia up-regulated were measured with COVID-19 [DOI] 10.1016/j.cyto.2022.155870 PMC 바로가기 [Article Type] Article
Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients간세포암 환자에서 SARS-CoV-2 감염에 대한 표적 및 약물 예측Article Published on 2022-05-312022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Cell clinician Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical dataset datasets differentially expressed differentially expressed gene drug drugs effective effective drug effective drugs epithelial cell functional genomes HCC HCC patient HCC patients Hepatocellular carcinoma hub genes Human identify Ilomastat infected with SARS-CoV-2 Interaction Kyoto lung epithelial microRNA MicroRNAs miRNA molecular Ontology pandemic pathway Patient patients Protein protein-protein interaction provide Research reveal SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synergistic synergistic effect target terminology therapeutic transcription factor transcriptomic analysis Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0269249 PMC 바로가기 [Article Type] Article