SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation [DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article
Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity천식에서 SARS-COV-2, SARS-COV-1, MERS-COV, HCOV-229E 및 인플루엔자 숙주 유전자 발현의 비교 연구 : 성별, 질병 중증도 및 상피 이질성의 중요성Comparative Study Published on 2021-06-052022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated airway allergy ANPEP Asthma asthmatic both sexes cells changes in Characteristics characterized ciliated cell ciliated cells club Comparative coronavirus COVID-19 disease downregulation DPP4 epithelial epithelium expression Factor female GAL4 Gene Expression goblet HCoV HCoV-229E heterogeneity human coronavirus Importance increase in Inflammation Influenza influenza viral lack MERS MERS-CoV Mild moderate molecular occurred Patient protease Proteases receptor SARS SARS-CoV-1 SARS-CoV-2 severity Sex sexual dimorphism SLC6A19 ST3GAL4 ST6GAL1 susceptibility Th2 TMPRSS2 TMPRSS4 transcriptomic data upregulated Viral viral entry viral infection viral infections virus [DOI] 10.3390/v13061081 PMC 바로가기 [Article Type] Comparative Study
Detection of SARS-CoV-2 RNA in the corneal epithelium of a patient after recovery from COVID-19Case report Published on 2021-06-012022-10-05 Journal: American Journal of Ophthalmology Case Reports [Category] 치료기술, [키워드] active viral replication Acute respiratory infection acute respiratory syndrome addition African American aqueous fluid Care Cornea Corneal coronavirus COVID-19 described detection determine discharged edematous elevated epithelium Follow-up herpes simplex herpes zoster hospital Hospitalized hypertension Importance Keratouveitis lack observation ocular ophthalmic Patient PCR polymerase chain positive presenting required SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA specimen Swab tissue Treatment Uveitis valacyclovir varicella Viral RNA virus [DOI] 10.1016/j.ajoc.2021.101074 [Article Type] Case report
Insights Into the Effects of Mucosal Epithelial and Innate Immune Dysfunction in Older People on Host Interactions With Streptococcus pneumoniae노인에서 점막 상피 및 선천 면역 기능 장애가 폐렴구균과의 숙주 상호작용에 미치는 영향에 대한 통찰력Article Published on 2021-05-252024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] epithelium Inflammageing Innate immunity older individuals pneumococcus (Streptococcus pneumoniae) [DOI] 10.3389/fcimb.2021.651474 PMC 바로가기
Predictive effects of IgA and IgG combination to assess pulmonary exudation progression in COVID-19 patientsCOVID-19 환자의 폐삼출 진행을 평가하기 위한 IgA 및 IgG 조합의 예측 효과Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, [키워드] Admission alveolar epithelium Analysis average biopsy blood gas blood gas analysis chemiluminescence Cohort Combination correlated COVID-19 COVID-19 patient COVID-19 patients Defense destruction Deterioration edematous Effect Effects enlargement epithelium feces gas analysis highest Hospital admission Hypoxemia hypoxia IgA IgA level IgA levels IgG IgG level IgG levels Immunoglobulin immunoglobulin A Invasion lung moving average mucosa oxygen oxygenation index positive rate predict prediction effects. progression pulmonary lesion pulmonary lesions SARS-CoV-2 serum severe COVID-19 patients sputum Viral viral RNA detection was tested was used [DOI] 10.1002/jmv.26437 PMC 바로가기 [Article Type] Article
Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral InfectionsReview Published on 2021-01-292022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory disease acute respiratory syndrome airways arising Bearing Cell cellular and molecular changes in chronic respiratory disease ciliary ciliated ciliated cells clearance coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 Defense develop directional disrupt driven by dysfunction elicit epithelial epithelium Genetic goblet cells Health healthy help host infection Human implication include individual Infection integrity Interaction involved lethal infection lung lung cilia maintain management MCC mechanism microbial infection microbial infections molecular molecular component Mucociliary clearance Mucus nasopharynx novel virus pandemic pathogen pathophysiology Patient predicted Protein pulmonary Pulmonary function regulate respiratory Respiratory disease respiratory diseases respiratory epithelium Respiratory system respiratory tract SARS-CoV-2 viral simple Surveillance susceptible transcriptional [DOI] 10.3390/biology10020095 PMC 바로가기 [Article Type] Review
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster ( Mesocricetus auratus ) and Its Possible Implications in SARS-CoV-2 Related StudiesPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 expression age Analysis Angiotensin converting enzyme-2 angiotensin-converting enzyme 2 animal model antibody clinically conducted COVID 19 demonstrated detectable disease epithelial cells epithelium evaluate evaluated Evidence expresse expression functional group hamster hamster (Mesocricetus auratus) human tissue immunofluorescence analysis immunohistochemistry intestine kidney knowledge lack liver lung Mesocricetus mRNA level organ pathology predominant Protein provided proximal reagent receptor RT-qPCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Sex small intestine the antibody tissue tissue-specific expression tongue tracheal [DOI] 10.3389/fphar.2020.579330 PMC 바로가기 [Article Type] Pharmacology
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface표면 성인 인간 결막, 윤부 및 각막 상피에서 SARS-CoV-2 진입 유전자의 동시 발현은 안구 표면을 통한 추가 진입 경로를 제안합니다Article Published on 2021-01-012022-09-10 Journal: The Ocular Surface [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 ACE2 and TMPRSS2 expression ACE2 receptor Analysis Cell chromatin co-expression Conjunctiva conjunctival Cornea Corneal dataset embryonic ENhance epithelium expression pattern facilitate Factor fetal IFNg Immunohistochemical analysis Infection infection rate Inflammatory investigated loci molecular mechanism molecular mechanisms Multiple studies multiple study Ocular surface portal pro-inflammatory signal Propagation protease TMPRSS2 provide Result RNA SARS-CoV-2 SARS-CoV-2 entry Single Cell single-cell TMPRSS2 TMPRSS2 expression TNF transcriptional transmission route upregulation upstream Viral viral entry [DOI] 10.1016/j.jtos.2020.05.013 PMC 바로가기 [Article Type] Article
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection상피와 내피 사이의 혼선은 SARS-CoV-2 감염 동안 인간의 폐포-모세혈관 손상을 중재합니다Article Published on 2020-12-082022-09-11 Journal: Cell Death & Disease [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] affected alveolar epithelial cells alveolar epithelium Analysis attack autophagy cause caused change changes in co-culture contributed COVID-19 cross-talk damage disease elicited Endothelial cell endothelial cells Endothelium epithelial cell epithelial cells epithelium expand Health Health crisis host cells inhibit inhibitor Injury leads Lung infection Mechanisms of disease mitochondrion modulation molecular basis organelle pandemic Protein proteomic response SARS-CoV-2 SARS-COV-2 infection TEM Viral viral infection virus replication while [DOI] 10.1038/s41419-020-03252-9 PMC 바로가기 [Article Type] Article
Virions and respiratory droplets in air: Diffusion, drift, and contact with the epitheliumReview Published on 2020-12-012023-07-13 Journal: Bio Systems [Category] SARS, [키워드] Convection Diffusion and drift epithelium Evaporation Respiratory droplets viruses [DOI] 10.1016/j.biosystems.2020.104241 PMC 바로가기 [Article Type] Review