Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy진단 및 치료를 위한 감염성 질환 및 독소에 대한 파지 디스플레이에 의한 재조합 항체 개발Review Published on 2021-07-072022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] Against antibodies antibody antibody fragment Autoimmune diseases Bacterial Cancer caused convalescent patient COVID-19 pandemic Developing Diagnosis diagnostic disease Diseases display DNA sequence eukaryotic Final human monoclonal antibodies immune immune systems in vitro in vivo Infectious disease limitation microbial monoclonal antibody packaged Particles pathogen Pathogens phage phage display recombinant recombinant antibodies scFv antibodies selected sera therapeutic therapy toxin toxins treat Treatment VHH antibodies while [DOI] 10.3389/fcimb.2021.697876 PMC 바로가기 [Article Type] Review
Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus MonkeysSARS-CoV-2의 수용체 결합 도메인을 표시하는 자가 조립 나노입자 백신은 붉은털 원숭이에서 강력한 보호 면역 반응을 이끌어냅니다Article Published on 2021-05-192022-09-11 Journal: Bioconjugate chemistry [Category] SARS, 비임상, 진단, [키워드] Analysis Antigen benefit breath candidate vaccine caused Cell Clinical trial design COVID-19 pandemic cross-neutralize domain effective effective vaccine Efficiency elicit eukaryotic expression ferritin Focusing Humoral immunity immune response immunization immunization program immunized Infection inhibited isolates Monkey nanoparticle nasal Neutralizing antibodies neutralizing antibody new SARS-CoV-2 observation pathology platform protection test purified RBD respiratory response Rhesus monkey Rhesus monkeys Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 virus significantly specific antigen Spike protein T cell the vaccine Vaccine vaccine candidate vaccine platform virus replication [DOI] 10.1021/acs.bioconjchem.1c00208 PMC 바로가기 [Article Type] Article
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis게놈 전반에 걸친 생물정보학 분석으로 SARS-CoV-2 발병의 주요 숙주 및 바이러스 요인 예측Article Published on 2021-05-172022-09-10 Journal: Communications Biology [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age Analysis analyzed Betacoronavirus caused Computational biology and bioinformatics conserved contribute coronavirus COVID-19 CSF2 differentially expressed eIF4b eukaryotic Factor Genes help heterogeneous hnRNPA1 Host host gene expression host response host–pathogen interactions human gene human genes human respiratory cell human respiratory cells identify IL-6 IL32 Infection initiation factor interact Interaction isoform isoforms life cycle mechanism novel Betacoronavirus nuclear predict predicted Protein reduce respiratory respiratory cells ribonucleoprotein RNA SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 pathogenesis sequence sequencing data SERPINA3 severe acute respiratory syndrome Coronavirus severity of COVID-19 statistically significant the SARS-CoV-2 genome Therapeutics transcriptomics transposable element upregulated variant Viral viral genome sequence viral infection viral life cycle Viral RNA worldwide pandemic Wuhan Wuhan, China [DOI] 10.1038/s42003-021-02095-0 PMC 바로가기 [Article Type] Article
Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2SARS-CoV-2에 대한 항바이러스 펩티드의 활성에 대한 강력한 증거Opinion Published on 2021-05-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AMP AMPs anticancer antimicrobial peptide antimicrobial peptides antiparasitic Antiviral antiviral activities antiviral drugs antiviral peptides approved Bacteria caused clinical development clinical trial clinical trials coronavirus COVID-19 Defensins deficiency disease Ebola virus Efficacy Epidemic eukaryotic Evidence Evolution human cell human cells include insecticidal leads low molecular weight mechanism Multiple occurred optimization Organisms outbreak pandemic peptide peptide-based peptides produced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus specificity therapeutic Toxicity treat viral disease Viral diseases Zika virus [DOI] 10.3390/v13050912 PMC 바로가기 [Article Type] Opinion
Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severityResearch Published on 2021-04-142022-10-29 Journal: Microbiome [Category] COVID-19, MERS, SARS, [키워드] active viral replication Admission Affect age alteration association Asymptomatic Bacterial Blood Blood level blood specimen caused cells co-morbidities collected Control Coronavirus disease 2019 correlated COVID-19 COVID-19 cases COVID-19 patient COVID-19 severity Critical discharge disease disease course disease severity DNA DNA repair DNA virus DNA viruses enrolled eukaryotic explain fecal Fecal sample fecal samples gastrointestinal tracts Gender gene encoding Gut highlight Hospitalization Host host immunity Inclusion Inflammatory marker intestinal cells inverse correlation investigated Lineage metabolism Mild moderate Neutrophils Non-COVID-19 observation older subject outcomes parameters pathophysiology Patient pro-inflammatory Proteins regulate reported Result RNA RNA virus SARS-CoV-2 SARS-COV-2 infection sequenced Sequencing severity severity of COVID-19 specimen subject subjects supplementary material Temporal These viruses understanding unmet need virulence virus white cell with COVID-19 [DOI] 10.1186/s40168-021-01008-x PMC 바로가기 [Article Type] Research
Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by GrazoprevirArticle Published on 2021-03-312022-10-04 Journal: Scientific Reports [Category] 신약개발, [키워드] Analysis anti-viral drug approved Area Clinical studies clinical study complex Computational biophysics coronavirus disease COVID-19 COVID-19 pandemic demonstrated Drug discovery and development drug resistance Dynamics effective eukaryotic FDA Grazoprevir HCV hepatitis C host cell Hypothesis indicated interact Interaction Keeping Mechanics multiple pathway novel corona virus pathway Replication residue RNA-dependent RNA polymerase serine protease stability Structural analysis surface synergistic targets TMPRSS2 Treatment unlikely viral entry Viral proteins viral replication [DOI] 10.1038/s41598-021-86712-2 PMC 바로가기 [Article Type] Article
NSP16 2′-O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments StrategiesReview Published on 2021-03-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 2′-O-MTase activate affecting Animal host binding conserved coronavirus deaths Degradation disease enzymatic activity eukaryotic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Host host immunity human coronavirus human coronaviruses humans infect infecting infections information life-threatening mechanism MERS-CoV mRNA mutant strain nonstructural protein 16 Novel coronavirus nsp10 prevention problem PROTECT Protein provide public health SARS-CoV SARS-CoV-2 Seven Strategy Therapeutic approach Treatment treatment strategy upper respiratory tract variety virus [DOI] 10.3390/v13040538 PMC 바로가기 [Article Type] Review
The H + -ATPase (V-ATPase): from proton pump to signaling complex in health and diseaseTheme Published on 2021-03-012022-10-28 Journal: American journal of physiology. Cell physiology [Category] COVID-19, MERS, SARS, [키워드] acidification activity addition Cancer Cell cell membranes cell type cell types cells cellular processes complex contributing to COVID-19 pandemic diabetes disease Diseases Endosomal acidification endosomal trafficking eukaryotic event Extracellular Factor function Health implication include increasingly Interaction interactions intracellular vesicle involved kidney male mucosa neurodegenerative occur olfactory organ system pathophysiological pathophysiology pH regulation physiological plasma membrane Protein proton gradient proton pumping ATPase Regulation reproductive Signaling transmembrane V-ATPase viral infection [DOI] 10.1152/ajpcell.00442.2020 PMC 바로가기 [Article Type] Theme
Structure Unveils Relationships between RNA Virus PolymerasesArticle Published on 2021-02-172022-10-28 Journal: Viruses [Category] COVID-19, [키워드] automated characterized Cluster comparison double-stranded RNA eukaryotic functional homologous hosts infecting mechanism Phylogenetic Phylogenetic tree positive-sense primer Protein protein evolution protein structure RdRP RdRps relationship residue RNA RNA primer RNA virus RNA virus taxonomy RNA viruses RNA-dependent RNA polymerase sequence similarity similarity structural alignment structural conservation Structure structure comparison structures Topology Transcription Viral protein virus [DOI] 10.3390/v13020313 PMC 바로가기 [Article Type] Article
Uncovering potential host proteins and pathways that may interact with eukaryotic short linear motifs in viral proteins of MERS, SARS and SARS2 coronaviruses that infect humansResearch Article Published on 2021-02-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] caused component composed coronavirus coronavirus protein dissemination effective eukaryotic Host host cell host cells host protein Human humans immune evasion Improved in viral infect infecting intracellular protein kinases linear MERS motif Novel coronavirus pandemic pathway potential mechanism potential therapeutic target Protein Proteins provide receptors RNA viruses SARS-CoV-2 SARS2 Spread target transcription factor viral infections viral pathogenesis Viral protein virus replication [DOI] 10.1371/journal.pone.0246150 PMC 바로가기 [Article Type] Research Article