Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다Article Published on 2022-06-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19 [DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article
Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia중증 COVID-19 폐렴 노인 환자의 분자 및 세포 면역 특징Article Published on 2022-06-162022-09-12 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] activated activated macrophage age aging anti-RBD anti-S anti-viral response antibodies CD4 CD56 Cell cellular central memory circulating Clinical outcome collagen concerning Cytokines difference disease severity elderly exacerbate feature fibrosis follicular helper T cell IgG3 immature immune immune characteristics immunological change individuals Infection Inflammation less lung macrophages monocyte mononuclear cells Patient patients percentage Peripheral blood plasma plasmablasts pro-inflammatory cytokines pro-inflammatory monocytes promote proportion reduced reported risk factor SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severe SARS-CoV-2 specific antibody subject T cell T cells Transcriptome transcriptomic profile [DOI] 10.1038/s42003-022-03537-z PMC 바로가기 [Article Type] Article
COVID-19 Preventive Measures in Northern California Jails: Perceived Deficiencies, Barriers, and Unintended Harms북부 캘리포니아 감옥의 COVID-19 예방 조치: 인식된 결함, 장벽 및 의도하지 않은 피해Article Published on 2022-06-142022-09-12 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI adjusted Administered antibody Antibody testing Characteristics community-based research condition COVID-19 COVID-19 diagnosis COVID-19 transmission Deprivation effort enrolled exacerbate Face masks Factor hidden Impact implementation incarcerated incarceration individuals Infection infection control Interpretation Isolation jails likelihood lockdown Masks measure Mental mental health mitigate multivariable logistic regression pandemic Perceived performed positive questionnaire reported Research resident response SARS-CoV-2 Seroprevalence significantly stakeholder engagement Study design Symptom tested vaccination [DOI] 10.3389/fpubh.2022.854343 PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련Article Published on 2022-06-032022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication [DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article
Prevalence and associated factors of depressive symptoms among the young adults during the post-epidemic period — Evidence from the first wave of COVID-19 in Hubei Province, ChinaResearch article Published on 2022-06-012022-10-05 Journal: Acta Psychologica [Category] COVID19(2023년), SARS, 변종, [키워드] adopted Adults Affect age analyses being center China city conducted COVID-19 COVID-19 epidemic Depression depressive symptom Depressive symptoms Descriptive statistics employment Epidemic exacerbate Factor Final First wave household size Hubei Province identify investigated life Logistic regression analysis male Mental Post-epidemic period Prevalence Psychological psychological crisis intervention public health questionnaire random reported Resilience Result returned scale significantly statistical analysis stratified Stress Symptom was used were measured young adults [DOI] 10.1016/j.actpsy.2022.103577 [Article Type] Research article
Outcomes of acute limb ischemia in COVID-19Research article Published on 2022-06-012022-10-05 Journal: Journal of vascular surgery [Category] 진단, [키워드] Acute limb ischemia acute renal failure acute respiratory syndrome analyses arterial thromboembolism assisted ventilation baseline Care caused classification cohort characteristics collected Comorbidities Comorbidity complications Consequences coronavirus coronavirus disease COVID-19 defined demographics determine develop diagnostic event events exacerbate Health hospitalized patient identify Infection inflammatory cascade Ischemia less limb mental health Mortality Myocardial infarction objective organization outcome Patient patient data patients with COVID-19 provide Respiratory failure Result SARS-CoV-2 Sepsis significantly significantly higher significantly more stroke the United State thrombosis variables was performed were used with COVID-19 worse prognosis [DOI] 10.1016/j.jvs.2022.04.038 [Article Type] Research article
Generalized erythrodermic psoriasis triggered by vaccination against severe acute respiratory syndrome Coronavirus 2중증급성호흡기증후군 코로나바이러스 2 예방접종으로 촉발된 전신적 홍피성 건선Review Published on 2022-06-012022-09-11 Journal: Dermatologic therapy [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine coronavirus 2 COVID-19 dose erythrodermic psoriasis exacerbate exacerbated Generalized generalized erythrodermic psoriasis illnesses include literature review medications mRNA mRNA-1273 mRNA-1273 vaccine observation potentially life-threatening psoriasis reported SARS-CoV-2 SARS-CoV-2 vaccination second dose second vaccination Treatment Trigger triggered unique vaccination Vaccine variant [DOI] 10.1111/dth.15464 PMC 바로가기 [Article Type] Review
Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosisCaspase-4/11은 염증 및 면역 혈전증을 촉진하여 SARS-CoV-2 감염의 질병 중증도를 악화시킵니다.Article Published on 2022-05-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated acute respiratory syndrome Blood CASP4 caspase caspase-11 Coagulopathy coronavirus CXCL1 detrimental disease severity downstream drug target effective endothelial damage exacerbate expressed expression Factor functions gene signature GSDMD Health homolog humans IL-6 immunothrombosis Infection Inflammation Inflammatory inflammatory mediator Innate immunity less lung Lung pathology Lungs maintain marker mice molecular target neutrophil new treatment strategy pathway promote protein level reduced SARS-COV-2 infection SARS–CoV-2 severe COVID-19 severity targeting therapeutic thrombosis transcription factor transcriptomics Treatment up-regulated Vascular vessel viral titer von Willebrand factor weight loss wild-type [DOI] 10.1073/pnas.2202012119 PMC 바로가기 [Article Type] Article
Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patientsSARS-CoV-2에 대한 초기의 강력한 항체 반응은 COVID-19 환자의 질병 중증도를 예측합니다Article Published on 2022-04-152022-09-11 Journal: Journal of Translational Medicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료법, [키워드] antibody antibody levels Antibody profile Antibody Response Antibody responses Antibody-dependent enhancement Antigen Antigen microarray Biomarker Candidates cell activation Clinical significance correlated COVID-19 COVID-19 patient disease disease severity elicit epidemiological studies exacerbate frequencies Frequency full length healthy controls idea IgA IgA response IgA responses IgE IgG IgM response IgM responses implication levels of antibody mast cell Mast cells Mild disease MOST nonstructural protein nucleocapsid Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 peak levels Planning predict Prevalence Prognosis prognostic Protein recent response Result risk S protein SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens sera serological studies SEROLOGICAL STUDY Serum level severe disease severity Spread Support testing antibody the disease the vaccine vaccine candidates virus with mild disease [DOI] 10.1186/s12967-022-03382-y PMC 바로가기 [Article Type] Article