Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replicationArticle Published on 2020-08-272022-10-04 Journal: Nature Communications [Category] 변종, 치료제, [키워드] 3CL pro block Cell culture cleavage coronavirus Coronavirus infection COVID-19 crystal structure Cys145 drug candidate drug target effective inhibitor Feline infectious peritonitis inhibit inhibitor inhibitors of SARS-CoV-2 M pro Modification NMR analysis nucleophilic polyprotein proceed protease Protease inhibitor Proteases Replication reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 replication Target identification treat treated Treatment Trial virus virus replication X-ray crystallography [DOI] 10.1038/s41467-020-18096-2 PMC 바로가기 [Article Type] Article
In Vitro Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in CatsResearch Article Published on 2020-05-312022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, [키워드] antiviral activity Antiviral effect average bead-based multiplex immunoassay Bioavailability biological activity C max Cell chitosan Crandell-Rees feline kidney cuboidal Curcumin decrement Effect Evidence expression Feline infectious peritonitis high mortality rate HPLC IL-1 β IL-6 immune-related protein immunoassay IMPROVE Infection Inflammatory response lower toxicity Multiple-dose multiplex nanoparticle Necrosis notable oral oral bioavailability peritonitis pharmacokinetics plasma concentration profile proinflammatory cytokines provide qPCR selective synthesised therapeutic TNF TNF α Treatment viral disease virus were used [DOI] 10.1155/2020/3012198 PMC 바로가기 [Article Type] Research Article
Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus InfectionCommunication Published on 2020-05-242022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] antiviral activity antiviral drug Antiviral effect approved association clinical study Combination coronavirus country dengue virus Effect effective Feline coronavirus Feline infectious peritonitis HCQ humans Hydroxychloroquine immune-mediated disease in vitro Infection inhibited interferon investigated malaria morbidity and mortality Registered Replication Safe SARS-CoV-2 significantly suggested treat Treatment Type type I viral disease viral infection virulent virus [DOI] 10.3390/v12050576 PMC 바로가기 [Article Type] Communication
In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum ( Trichosurus vulpecula )Research Article Published on 2020-04-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] canine caused clearance clinically cofactor determine Efficacy and safety evaluate Feline infectious peritonitis hepatic function immune-mediated disease in vitro inhibit intrinsic LC-MS liquid mefloquine metabolism negative controls Phase I positive control Protein shown tramadol Treatment viral-induced virus was used [DOI] 10.1371/journal.pone.0230975 PMC 바로가기 [Article Type] Research Article
Effect of cat litters on feline coronavirus infection of cell culture and catsOriginal Articles Published on 2020-04-012022-10-29 Journal: Journal of Feline Medicine and Surgery [Category] Coronavirus, MERS, [키워드] abrogate abrogated applicability Bentonite cat litter caused Cell culture centrifuged contagious coronavirus Coronavirus infection Dr Elsey Effect FCoV infection Feline coronavirus Feline infectious peritonitis FIP Frequency Fuller’s earth greater had no in vitro in vitro result in vitro study incubated Infection inhibitory Interpretation investigated less nine objective performed Prevent prevented quantitative PCR rectal swab reduced reducing virus load Reinfection Result supernatant tested transcriptase Transmission virus virus infection virus inhibition virus load was measured [DOI] 10.1177/1098612X19848167 PMC 바로가기 [Article Type] Original Articles
Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans530 Published on 2020-01-212022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, [키워드] Activation alphacoronavirus analyses Analysis cause cleavage site complex protein coronavirus spike protein CoV cryo-EM cryo-EM structure Cryoelectron microscopy demonstrated domain effective feasibility feature Feline infectious peritonitis Feline infectious peritonitis virus glycan glycosylation high-mannose highlight Host mass spectrometry Microscopy molecular mortality rate N-glycan Pathogenesis Protein protein glycosylation provided reported responsible resulting reveal S protein S proteins S2 subunit serotype Significance structures the S1 subunit Treatment unique viral entry virus [DOI] 10.1073/pnas.1908898117 PMC 바로가기 [Article Type] 530
A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline CoronavirusesReview Published on 2020-01-102022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Analysis antigenic variants cause Characteristics clinical manifestation clinical settings complex coronavirus effective Feline coronavirus Feline infectious peritonitis functional Genetic Genetic characterization glycoprotein implication occur outcomes resulting S protein serological serotype serotypes spike Spike protein the S protein translate variety virus viruses [DOI] 10.3390/v12010083 PMC 바로가기 [Article Type] Review
Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple SitesArticle Published on 2019-12-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] activate caused cleavage cleaving coronavirus death demonstrated DF2 Diseases evade Feline infectious peritonitis Genome Host IFN response IFN-β immune response induce Infection inhibited innate immune response interferon regulatory factor interferon-stimulated gene IRF3 ISG mechanism Multiple NEMO NF-κB non-structural protein nsp5 nuclear peritonitis Phosphorylation Production promoter provide recruitment reduced reported Research Sendai virus Signaling Site TANK TRAF Type type I Type I IFN type I interferon virulent virus [DOI] 10.3390/v12010043 PMC 바로가기 [Article Type] Article
Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the PathogenesisArticle Published on 2019-12-102022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] amplifying Cardiomyocytes circulating leukocytes Combination coronavirus cytokine cytokine release Cytokines demonstrated determine develop disease exacerbate Factor feature Feline coronavirus Feline infectious peritonitis Fever heart hepatocytes Host IL-12 IL-1β IL-6 immune immune-mediated disease include induce Inflammation Inflammatory Inflammatory cytokines liver marker mRNA expression organ organs Pathogenesis peritonitis previous study pro-inflammatory pro-inflammatory state Result skewed suggested systemic systemic inflammatory response tissue TNF-α Vasculitis [DOI] 10.3390/v11121144 PMC 바로가기 [Article Type] Article
Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitisOriginal Article Published on 2019-11-152022-10-29 Journal: Journal of Feline Medicine and Surgery [Category] Coronavirus, [키워드] 95% CI 95% confidence interval association Blood calculated cerebrospinal fluid clinical conditions Combination contribute coronavirus diagnosed EDTA examined Examining FCoV Feline infectious peritonitis FIP gene mutation highlight Host IHC immune response immunohistochemistry incisional biopsy Infection investigated kidney liver Lymph node lymph nodes macrophages mutate mutated Mutation nucleotide objective popliteal positive Prevalence Probability real-time RT-PCR Replication Result RT-PCR S gene Sample serum spike gene spleen Spread tissue Variation virulence virulent [DOI] 10.1177/1098612X19886671 PMC 바로가기 [Article Type] Original Article