Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trialClinical Trial Published on 2022-06-072022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI administration Adverse age Antigen assigned AstraZeneca block sizes blocked clinical clinical evaluation clinically collected conducted Course COVID-19 COVID-19 vaccination death dose double-blind Efficacy enrolled enrolment Europe evaluate event Fever finding for inclusion funding individual intramuscular intramuscular injections investigators involved Japan laboratory-confirmed SARS-CoV-2 infection Latin America less Mild moderate Moderate COVID-19 monoclonal antibody combination non-hospitalised occurred Older outcomes participant Phase 3 Placebo placebo-controlled study placebo-controlled trial prevent disease progression primary endpoint progression provided randomisation randomised Randomly receive Registered required respiratory tract risk reduction RT-PCR scale severe COVID-19 severity specimen Sponsor statistically stratified study drug Symptom symptom onset the disease the placebo group treating Treatment treatment group USA WHO [DOI] 10.1016/S2213-2600(22)00180-1 [Article Type] Clinical Trial
Advances in Clinical Cardiology 2021: A Summary of Key Clinical Trials임상 심장학의 발전 2021: 주요 임상 시험 요약Review Published on 2022-06-012022-09-11 Journal: Advances in therapy [Category] 임상, [키워드] Acute coronary syndrome acute coronary syndromes advance AHA American Heart Association angiography antiplatelet Antiplatelets Aortic valve Atrial fibrillation Cardiac arrest Cardiology cardiovascular clinical clinical trial clinical trials clinicians and researchers college Community Coronary Coronary artery Coronary artery disease Coronary revascularisation Course COVID-19 drug Electrophysiology European evaluated Evidence for inclusion Glucose heart heart failure hospital hypertrophic cardiomyopathy inhibitors International Intervention left Left atrial appendage closure lipids mavacamten Mechanical Mechanical support mitral Mitral clip Myocardial infarction New over PCSK9 Percutaneous prevention Pulmonary valve Quantitative rhythm Sacubitril sacubitril/valsartan SCAI Shock Society sodium Summit technology Therapeutics Transcatheter Transcatheter aortic valve implantation Transcatheter tricuspid valve interventions. Treatment Trial tricuspid tricuspid valve valsartan valve replacement [DOI] 10.1007/s12325-022-02136-y PMC 바로가기 [Article Type] Review
Feasibility of non-invasive respiratory drive and breathing pattern evaluation using CPAP in COVID-19 patientsObservational Study Published on 2022-06-012022-10-04 Journal: Journal of critical care [Category] 임상, [키워드] Acute respiratory failure AHRF airway collected conducted consecutive patient Continuous Continuous Positive Airway Pressure COVID-19 COVID-19 patient CPAP Diaphragm effort feasibility feasible feature for inclusion fraction help HFNC High flow nasal cannula hypoxemic Increased inspiratory flow Intubated intubated patient intubation material measurement minute ventilation nasal non-intubated patients Non-invasive P0.1 parameter Patient patients with AHRF Physiologic positive positive airway pressure predict Predictive prospective observational study repeated respiratory Respiratory drive. Respiratory failure screened significant increase significantly higher Volume [DOI] 10.1016/j.jcrc.2022.154020 PMC 바로가기 [Article Type] Observational Study
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
Comparison of COVID-19 outcomes in patients with Type 1 and Type 2 diabetes: A systematic review and meta-analysisReview article Published on 2022-06-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] 임상, [키워드] age all-cause mortality rate Analysis approach assessment Clinical outcome Comorbidities Controlled trial COVID-19 COVID-19 patient diabete diabetes Diabetic disease severity eligible evaluate Evidence FIVE for inclusion Google group heterogeneous Hospitalization individual log Meta-analysis Mortality mortality rate no significant difference non-randomized observational study outcome outcomes Patient Prognosis Quality random-effect RCTs reported Research Result Sample size searched shown subject systematic review Total trials Type Type 1 diabetes mellitus type 2 diabetes Type 2 diabetes melltitus was used Web of Science [DOI] 10.1016/j.dsx.2022.102512 [Article Type] Review article
Designing an evidence-based Bayesian network for estimating the risk versus benefits of AstraZeneca COVID-19 vaccineAstraZeneca COVID-19 백신의 위험 대비 이점을 추정하기 위한 증거 기반 베이지안 네트워크 설계Article Published on 2022-05-112022-09-11 Journal: Vaccine [Category] 변종, [키워드] Adverse adverse events age AstraZeneca Atypical AZ vaccine Bayesian Bayesian network benefit blood clot Blood clots booster doses can be used Clinicians community transmission Comorbidities Comorbidity contribute COVID COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines determine Evidence expand expert for inclusion generate Government groups Health include individuals Informed Informed decision-making International Local methodology Model outcome outcomes provide researcher risk Sex These data thrombocytopenia thrombosis Uncertainty vaccination Vaccine hesitancy variables variant virus was used were used [DOI] 10.1016/j.vaccine.2022.04.004 PMC 바로가기 [Article Type] Article
Outcomes of SARS-CoV-2 omicron infection in residents of long-term care facilities in England (VIVALDI): a prospective, cohort studyArticle Published on 2022-05-012022-11-16 Journal: The Lancet. Healthy longevity [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age Alpha Analysis appear B.1.1.529 booster vaccination Care cohort study Course Coverage datasets death Department diagnosed disease severity eligible England excluded finding for inclusion hazard ratio Hospital admission indicated Infection investigated IQR Lateral flow device male median age MONITOR Mortality National National Health Service natural immunity NHS Observed Omicron variant outcome participant PCR Population positive positive PCR prospective cohort study PROTECT public health reduced reduction in resident risk risk of death SARS-CoV-2 SARS-CoV-2 test Sequencing severe disease severity Sex study period subset Surveillance tested unlikely Vaccine variant variants [DOI] 10.1016/S2666-7568(22)00093-9 PMC 바로가기
Immunogenicity and Safety of the COVID-19 Vaccines Compared With Control in Healthy Adults: A Qualitative and Systematic ReviewRandomized Controlled Trial Published on 2022-05-012022-10-04 Journal: Value in health : the journal of the International [Category] 비임상, 유전자 메커니즘, 임상, [키워드] 6 hour acute respiratory syndrome adverse event adverse events all-cause mortality antibody conducted Control control arm control group Controlled trial coronavirus COVID-19 COVID-19 vaccine death disease dose elicited emergence evaluate examined fatigue females Fever for inclusion geometric mean titer GMT GMTs group headache highest immune response immunogenicity Immunoglobulin Infection local reaction Mild mRNA-1273 neutralizing antibody Pain pandemic Placebo postvaccination profiles Qualitative ranged reaction reported retrieved review Safety seroconversion rates severe adverse event subject systematic review the healthy tolerable vaccination Vaccine Vaccines while [DOI] 10.1016/j.jval.2021.09.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impact of COVID-19 pandemic on acute stroke admissions and case-fatality rate in lower-income and middle-income countries: a protocol for systematic review and meta-analysis저소득 및 중간 소득 국가의 급성 뇌졸중 입원 및 사례 치명 비율에 대한 CovID-19 Pandemic의 영향 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-04-252022-08-31 Journal: BMJ Open [Category] meta-analysis, [키워드] 95% CI Abstract abstracts Admission African age Analysis Characteristics conducted COVID-19 COVID-19 pandemic critical appraisal Cross-sectional studies cross-sectional study database determine Egger eligibility criteria Epidemiology Ethical approval Ethics fatality for inclusion funnel plot Google Scholar Health Sciences heterogeneity Impact International involved Joanna journal Latin literature manuscript medRxiv meta-analyses Meta-analysis NEUROLOGY performed PROSPERO protocol Publication bia publication bias random-effect Random-effects meta-analysis registration number reported required Research risk of bia Science sensitivity analysis stroke submitted systematic review table [DOI] 10.1136/bmjopen-2021-057893 PMC 바로가기 [Article Type] Article
Clinical efficacy and safety of high-flow nasal cannula (HFNC) in acute hypoxaemic patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19를 가진 급성 저산소병 환자에서 고유 유량 코 캐뉼라 (HFNC)의 임상 효능 및 안전성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-04-122022-08-31 Journal: BMJ Open [Category] meta-analysis, [키워드] Acute respiratory failure adult intensive & age and sex approach Caregivers clinical Clinical efficacy Cochrane Library Continuous data COVID-19 COVID-19 patient COVID-19 patients Critical Critical care data extraction determine develop disease severity Efficacy and safety eligibility criteria Ethical approval Ethics evaluate for inclusion HFNC High-flow nasal cannula hypoxaemic respiratory failure identify increased risk Infection transmission infections Intensive intensive care intensive care unit intubation mean difference meta-analyses Meta-analysis Mortality nasal nasal cannula outcome Participants Patient peer-reviewed performed Primary outcome PROSPERO protocol randomised controlled trial RCT RCTs registration number required respiratory Respiratory failure respiratory infections risk risk of bia risk ratio secondary outcome Secondary outcomes Subgroup analyses subgroup analysis systematic review the mean Treatment undergo Web of Science [DOI] 10.1136/bmjopen-2021-057743 PMC 바로가기 [Article Type] Article