Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential항고혈압 및 항-COVID-19 잠재성을 지닌 높은 용해도 및 내구성을 갖는 공동-비정질 발사르탄/니코틴아미드 조성물의 형성에서 수소 결합의 역할Article Published on 2021-04-012022-08-31 Journal: Molecular Pharmaceutics [Category] 치료제, [키워드] (nicotinamide) acting active pharmaceutical ingredient analyses angiotensin Angiotensin II anti-hypertensive applied approaches Bioavailability bond caused characterized co-amorphization conformational change conformational changes coronavirus COVID-19 Density functional theory Donor drug drugs Effects Efficacy exhibit flexible Formation functional heterodimeric hydrogen Hydrogen bond hydrogen bonds hypertension ingredient Interaction key factor liquid low molecular weight lung market molecules NIC nicotinamide pandemic coronavirus Physicochemical properties Potential quantum theory receptor receptor blocker responsible role SARS-COV-2 infection solid dispersion solubility treat valsartan X-ray [DOI] 10.1021/acs.molpharmaceut.0c01096 PMC 바로가기 [Article Type] Article
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass SpectrometryArticle Published on 2021-03-162022-10-29 Journal: SLAS discovery : advancing life sciences R & D [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome Analysis Antiviral conserved coronavirus Coronavirus-2 Coronaviruses COVID-19 COVID-19 infection develop development drug drugs Efficiency enzyme evade exonuclease food Formation Health help Host in viral inhibitor mass methyltransferase nsp14 Outbreaks Protein Replication responsible SARS-CoV SARS-CoV-2 Screening selective shown similarity specific treatment Spectrometry starting point the SARS-CoV-2 therapy translation viral genome Viral RNA [DOI] 10.1177/24725552211000652 PMC 바로가기 [Article Type] Article
The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?Perspective Published on 2021-02-162022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] accumulate acute respiratory distress acute respiratory syndrome Bacterial coinfection balance boost Coinfection Contact contribute coronavirus COVID-19 COVID-19 patient Defense Degradation degrade described detrimental effect DNase Evidence extracellular DNA fiber Formation Host humans immunothrombosis Infection NET NETs neutrophil Neutrophil extracellular trap Neutrophils Nuclease Pathogenesis peptides public health released role SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity syndrome the disease therapeutic strategy Treatment treatment strategy Unknown Vascular [DOI] 10.1128/mBio.03304-20 PMC 바로가기 [Article Type] Perspective
COVID-19-associated Large Vessel Stroke in a 28-year-old Patient NETs and Platelets Possible Key Players in Acute Thrombus FormationCorrespondence Published on 2021-01-292022-10-31 Journal: Clinical Neuroradiology [Category] Coronavirus, MERS, SARS, [키워드] Formation NET [DOI] 10.1007/s00062-020-00992-1 PMC 바로가기 [Article Type] Correspondence
Significance of NETs Formation in COVID-19Review Published on 2021-01-142022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE2 base cellular combating contagious coronavirus Course COVID-19 COVID-19 in patient COVID-19 pathogenesis elevated enzyme excessive inflammatory response Extracellular Formation IMPROVE Inflammation Interaction manuscript mechanism medication Metabolic diseases molecular NET NETs neutrophil Neutrophils Occurrence organs pathogenesis of COVID-19 Pathogens patients protease protein S reaction recruitment Regulatory Research Respiratory failure SARS-CoV-1 SARS-CoV-2 serine 2 Significance Spread Stress the SARS-CoV-2 therapeutic strategy therapy thromboembolic complication tissue TMPRSS2 Treatment [DOI] 10.3390/cells10010151 PMC 바로가기 [Article Type] Review
The Fatty Acid Lipid Metabolism Nexus in COVID-19COVID-19의 지방산 지질 대사 넥서스Review Published on 2021-01-112022-09-10 Journal: Viruses [Category] 치료제, [키워드] acid Activation acute respiratory syndrome Affect AMPK Antiviral assembly Clinical data complex coronavirus coronavirus protein Coronavirus replication COVID-19 COVID-19 immune response disease severity drugs endoplasmic reticulum stress response enteric envelope protein Evidence evidence of FASN fatty Fatty acid Formation Gut Immune homeostasis increase individual inhibit inhibition inhibitor Intervention intestine Lipid lipid metabolism liver mechanism membrane membrane protein metformin morbidly obese mTORC1 nexus nonstructural protein obese observation orlistat palmitoylation pancreas Protein protein kinase reduce Replication replicative organelle respiratory restoration Spike protein SREBP-1 systemic inflammation the disease therapeutic target unfolded protein response Viral viral replication virus replication [DOI] 10.3390/v13010090 PMC 바로가기 [Article Type] Review
IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 PatientsSARS-CoV-2에 대한 IgA2 항체는 중증 COVID-19 환자의 NET 형성 및 치명적인 결과와 상관 관계가 있습니다Communication Published on 2020-12-122022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody antibody level antibody levels C-reactive protein C-reactive protein (CRP characterized circulating contribute Control coronavirus correlated COVID-19 CRP level CRP levels extracellular DNA Formation Hospitalization Host ICU IgA IgA2 IgG response IgG responses Immune cell immune cells induce Infection Inflammation intensive care intensive care unit leads less marker mild symptoms moderate moderate symptoms NET neutrophil Neutrophil extracellular trap neutrophil extracellular trap (NET) organ injury outcome Patient patient groups patients plasma sample plasma samples respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-infected patient SARS-CoV-2-infected patients SARS-CoV-2-specific IgG severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease severe SARS severe SARS-CoV-2 specific antibodies Spike protein Symptom the strongest These data TRAP were measured while [DOI] 10.3390/cells9122676 PMC 바로가기 [Article Type] Communication
Quantification and Comparison of Droplet Formation During Endoscopic and Microscopic Ear Surgery: A Cadaveric Model내시경 및 현미경 귀 수술 중 물방울 형성의 정량화 및 비교: 사체 모델Comparative Study Published on 2020-11-032022-09-01 Journal: Otolaryngology--Head and Neck Surgery [Category] MERS, 진단, [키워드] 95% CI aerosol approaches Care cholesteatoma cortical COVID-19 COVID-19 pandemic deposition Diseases drilling droplet droplets ear Effect endoscopic ear surgery epitympanectomy Fluorescein Formation Health Health care Infectious diseases injected intensity Laboratory lowest mastoidectomy Microscopic Middle ear Model objective offer proportion quantified Quantitative raised reduction Research Result risk Risk assessment Safety setting significant increase specimen Spread surgical Temporal bone the disease ultraviolet light was recorded were assessed [DOI] 10.1177/0194599820970506 PMC 바로가기 [Article Type] Comparative Study
Bulla Formation and Tension Pneumothorax in a Patient with COVID-19Images in Clinical Tropical Medicine Published on 2020-09-082022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] Coronavirus, SARS, [키워드] Bulla Formation tension pneumothorax with COVID-19 [DOI] 10.4269/ajtmh.20-0736 PMC 바로가기 [Article Type] Images in Clinical Tropical Medicine
Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA ReplicationResearch Article Published on 2017-11-212022-10-29 Journal: mBio [Category] Coronavirus, [키워드] acute respiratory syndrome Affect biogenesis cleavage coexpressed convoluted membranes coronavirus Coronaviruses cytoplasmic electron tomography element Endoplasmic reticulum eukaryote Evidence expressed Formation highlight Human in viral induce lethal infection maturation membrane structure membranes MERS-CoV Middle East MIMIC Mutagenesis nidovirus nidoviruses nonstructural protein nonstructural proteins Nsp3 nsp4 organelle pathogen Pathogens polyprotein positive precursor proliferation Protein proteolytic Replication replication complex replication organelle biogenesis replication structures required Research respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus SARS-CoV similarity subunit suggested thought transmembrane transmembrane domains transmembrane protein Vesicle viral double-stranded RNA viral factory Viral protein [DOI] 10.1128/mBio.01658-17 PMC 바로가기 [Article Type] Research Article