Functional enrichment analysis – Page 3 – Communicable Diseases Research

Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19

COVID-19의 심각한 진행과 관련된 염증 및 항바이러스 면역 반응

Clinical Trial

Published on 2021-02-182022-08-13
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 severity Disease progression disease severity downregulation Ex vivo Functional enrichment analysis H1N1 H1N1 virus healthy controls hemagglutinin host immune system hypercytokinemia IFNs immune cells immune response immune signature impair impaired function include indicate indicated Infection Inflammation Inflammatory Inflammatory response Influenza influenza A interferons LAG3 microarray analysis mild COVID-19 patient MMP9 mononuclear cell mononuclear cells myeloid cell myeloid cells Neutrophils novel respiratory disease overactivation overactive patients patients with influenza PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells potential mechanism potential mechanisms progression promote proportion Protein regulate Regulation respiratory Respiratory disease respond response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe and mild COVID-19 patients severe COVID-19 severe SARS severe SARS-CoV-2 severity Signaling SKAP1 spike Spike protein Stimulation suggested T cell T cells T cells TLR6 Transcriptome Type I IFN type I IFNs type I interferon type I interferons unique upregulation whole genome transcriptome with COVID-19
[DOI] 10.3389/fimmu.2021.631226 PMC 바로가기 [Article Type] Clinical Trial

Prediction of SARS-CoV Interaction with Host Proteins during Lung Aging Reveals a Potential Role for TRIB3 in COVID-19

Short Communication

Published on 2021-02-012022-10-28
Journal: Aging and Disease [Category] COVID-19,

[키워드] α-hydroxylinoleic acid ACE2 aging alveolar damage alveolar epithelial cell analyzed Cell cellular coronavirus COVID-19 decrease decreased expression develop drug evaluated explain Express expressed expression Factor Functional enrichment analysis Genes help homolog Host human protein-coding gene individual individuals Infection lung lung aging male metabolism mitotic nucleocapsid protein Older Patient perturbations Pneumonia Potential potential therapy predicted prediction prevalent Protein Replication reported Respiratory failure RNA-dependent RNA polymerase role SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Severe case single-cell stimulate susceptibility the disease transcriptional change TRIB3 tribbles homolog 3 virus infection viruses
[DOI] 10.14336/AD.2020.1112 PMC 바로가기 [Article Type] Short Communication

A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection

네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.

Immunology

Published on 2020-12-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019 activating Antiviral antiviral response approach bind bioinformatics cause Cell Cluster Combination coronavirus COVID-19 Critical cytokine Cytokine storm Cytokines Defense depth analysis differentially expressed epithelial experimental validation expression Extensive fibrosis finding Functional enrichment analysis generate Genes highest host gene host genes host response human immune response IFN-α immune in-depth analysis infect Inflammatory Inflammatory response inhibit initiate ISGs leads Lower respiratory tract Lung fibrosis MCODE score mechanism molecular mechanism NFkB1 NHBE Organ failure pandemic pathway Pathways Patient potential mechanism POU2F2 pro-inflammatory cytokine pro-inflammatory cytokines protein-protein interaction receptor reducing referred to Regulation regulatory network respiratory Result resulting RNA sequencing robust antiviral response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients severe pneumonia Signaling signaling pathway STAT Stat1 STAT2 STAT3 storm suggested Suppressing Systems biology the cells the cytokine storm TNF transcription factor transcription factors Transcriptome Tuberculosis up-regulated Viral viral infection Vitamin Vitamin D were used
[DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology

Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer Analysis

Molecular Biosciences

Published on 2020-10-232022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 ACE2 expression ACE2 gene Affect Analysis analyzed B cell breast cancer patients Cancer cancer cell lines cancer patient cancer type cancers carried CD4+ T cells CD8+ T cells China Clinical prognosis conducted Coronavirus disease 2019 correlated correlation COVID-19 COX dendritic cells determine DNA elevated evaluated expressed expression expression level Frequency Functional enrichment analysis global pandemic GSEA HLA gene immune immune infiltration indicated infiltrating investigated Kaplan-Meier lung Macrophage macrophages malignant malignant tumor medium mismatch Mutation Neutrophils not correlated observational study organ Pan-cancer analysis pathway patients with pneumonia positive correlation Prognosis receptor regression analysis repair reported Result risk factor SARS-CoV-2 significantly Spread survival systematic analysis TCGA tested the SARS-CoV-2 virus tissues TMB Tumor tumors with COVID-19
[DOI] 10.3389/fmolb.2020.569414 PMC 바로가기 [Article Type] Molecular Biosciences