Gene Expression Omnibus – Page 3 – Communicable Diseases Research

COVID-19 Transcriptomic Atlas: A Comprehensive Analysis of COVID-19 Related Transcriptomics Datasets

Genetics

Published on 2021-12-222022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

SARS-CoV-2 Exacerbates Beta-Amyloid Neurotoxicity, Inflammation and Oxidative Stress in Alzheimer’s Disease Patients

SARS-CoV-2는 알츠하이머병 환자의 베타-아밀로이드 신경 독성, 염증 및 산화 스트레스를 악화시킵니다

Article

Published on 2021-12-192022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘,

[키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus Alzheimer’s disease Alzheimer’s disease beta-amyloid biological process Brain can not Cell cell cycle clearance Cohort collected Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 cohort deaths Dementia deregulated died Gene Expression Omnibus Health higher risk immune response individuals Inflammation interactome neurotoxicity Next-generation sequencing Ontology oxidative stress pandemic Patient profile Repository respiratory reveal SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transcriptome transcriptomic triggered Viral viral replication
[DOI] 10.3390/ijms222413603 PMC 바로가기 [Article Type] Article

Identification of Key Pathways and Genes in SARS-CoV-2 Infecting Human Intestines by Bioinformatics Analysis

Original Article

Published on 2021-11-172022-10-28
Journal: Biochemical Genetics [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation

네트워크 약리학, 레스베라트롤이 COVID-19 관련 과염증을 완화할 수 있음을 밝혀냄

Research Article

Published on 2021-09-222022-09-10
Journal: Disease Markers [Category] SARS, 유전자 메커니즘,

[키워드] Analysis Anti-inflammatory Antiviral antiviral agent approach benefit bioinformatic analysis Can COVID-19 COVID-19 patients COVID-19 therapy dataset DEGs differentially expressed gene enrichment analysis followed by gene analysis Gene Expression Omnibus Gene ontology GEO GO term GO terms GSE147507 hyperinflammation IL-17 involved KEGG KEGG pathway Kyoto location network notable overlap pathway pathway enrichment Pathways pharmacological pharmacological mechanism Pharmacology Potential protein-protein interaction resveratrol SARS-CoV-2 screened signaling pathway target targets therapeutic therapy TNF signaling
[DOI] 10.1155/2021/4129993 PMC 바로가기 [Article Type] Research Article

Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium

선입견 인간 자궁 내막에서 SARS-CoV-2 세포 진입 인자의 단일 세포 RNA 시퀀싱

Article

Published on 2021-09-182022-09-11
Journal: Human reproduction (Oxford, England) [Category] SARS, 치료기술,

[키워드] ACE2 Analysis ANPEP Asymptomatic COVID-19 Biohub biopsy board BSG canonical carriers caution CD209 Cell cell entry cell type cells chance CLEC4G Cohort conducted COVID-19 CTSB CTSL dataset Donor during pregnancy early pregnancy Efficiency epithelial cell epithelial cells European examined expressed expression expression of gene Factor Focusing framework furin Gene Expression Gene Expression Omnibus head healthy Horizon IFITM1 implication Infection Innovation luminal LY6E menstrual menstrual cycle Miguel NCBI NRP1 offer Pregnancy processed Program proliferative Proteases protein expression raw data receptor receptor ACE2 reported reproductive resource reveal risk risk of infection RNA sequencing SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 receptor scRNAseq Sequence Read Archive single-cell level Single-cell RNA-sequencing Spanish Stanford stromal cells supported the SARS-CoV-2 tissue TMPRSS11A TMPRSS2 TMPRSS4 transcriptomics transmission of SARS-CoV-2 Type union vertical transmission viral infection virus
[DOI] 10.1093/humrep/deab183 PMC 바로가기 [Article Type] Article

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients

특발성 폐섬유증 및 만성 폐쇄성 폐질환 환자에 대한 SARS-CoV-2 감염의 영향을 확인하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2021-09-022022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach bioinformatics Biomarker build candidate drug candidate drugs chronic obstructive chronic obstructive pulmonary disease confirmed COVID-19 case COPD coronavirus COVID-19 COVID-19 infection dataset datasets DEGs detect differentially expressed differentially expressed gene Differentially expressed genes drug molecule effective fibrosis functional Gene Expression Omnibus Gene ontology GEO GSE147507 help hub gene hub genes identify Idiopathic pulmonary fibrosis influence Interaction interactions IPF linkage molecular molecular mechanism molecular mechanisms obstructive pulmonary disease Ontology pathway Pathway analysis Patient patients performed PPI PPI network progression protein-protein interaction Protein–protein interaction protein–protein interaction (PPI). pulmonary disease pulmonary fibrosis risk factor Risk factors RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus second wave severe acute respiratory syndrome Coronavirus shared pathway shared pathways statistical System biology the epidemic the SARS-CoV-2 virus therapeutic transcription factors transcriptomic analysis underlie were used
[DOI] 10.1093/bib/bbab115 PMC 바로가기 [Article Type] Article

Construction of an autophagy interaction network based on competitive endogenous RNA reveals the key pathways and central genes of SARS-CoV-2 infection in vivo

경쟁적 내인성 RNA를 기반으로 한 자가포식 상호작용 네트워크의 구축은 생체 내 SARS-CoV-2 감염의 주요 경로 및 중심 유전자를 밝힙니다

Article

Published on 2021-09-012022-09-11
Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘,

[키워드] accompanied addition analyses Analysis autophagy bioinformatics biological processe biological processes Biomarker Biomarkers CCR2 central gene changes in construction Coronavirus infection COVID-19 CXCR4 cytokine receptor Cytokine storm datasets died differentially expressed differentially expressed miRNA differentially expressed miRNAs enriched pathway expression profile Gene Expression Omnibus GEO in vivo Infection Interaction investigated involved knowledge mechanism Messenger RNA microRNA MicroRNAs mild SARS-CoV-2 infection miRNA miRNAs MOST mRNA mRNAs Mutation pandemic Pathogenesis pathogenesis of SARS-CoV-2 pathway Pathway analysis patients with SARS-CoV-2 predict provided raw data receptor reveal RNA SARS-CoV-2 SARS-COV-2 infection severe symptom severe symptoms target the cytokine storm TP53INP2 variety virus strain virus strains
[DOI] 10.1016/j.micpath.2021.105051 PMC 바로가기 [Article Type] Article

Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics

Pharmacology

Published on 2021-08-312022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome addition analyzed approach Bronchial epithelium camptothecin can be used cause CDS Cell cell type cerebrospinal fluid characteristic CLC Cluster common cold Coronavirus disease-19 COVID-19 COVID-19 infection CSF dendritic cell disease enrichment analysis evaluated family Coronaviridae focus Gene Expression Omnibus gene expression profile gene signature gene signatures Genes Genomics GEO GSE147507 GSEA hypertension identification illness Illumina Immune cell JQ1 knowledge mock-treated Mortality multiple organ failure neuro-COVID Neurological complication next-generation knowledge discovery platforms NHBE novel Ontology Pathologies Pathways patients platform Potential Qiagen Quality control reversed RNA sequencing RNA-seq analysis RNA-seq read SARS-CoV-2 Sickness signature single-cell small molecule Small molecules stroke therapeutic potential Therapeutics transcriptomics trichostatin A United States upstream were used
[DOI] 10.3389/fphar.2021.688227 PMC 바로가기 [Article Type] Pharmacology

Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2

유방암에서 ATP6AP1의 예후 및 면역 학적 가치 : SARS-COV-2에 대한 시사점

Research Paper

Published on 2021-07-152022-08-31
Journal: Aging (Albany NY) [Category] 바이오마커, 변종,

[키워드] Accessory Alter association Atla ATP6AP1 ATPase bioinformatics Breast cancer Carcinogenesis cell type cell types co-expression correlated COVID-19 database disease stage enrichment estimation evaluate expression Factors Gene Expression Omnibus Human Immune cell immune cells immune infiltration immunological implication indicated infiltration investigated Kaplan-Meier methylated Methylation Multiple Mutation outcomes Patient Profiling Prognosis prognostic effect Prognostic value promote promoter reduced SARS-CoV-2 SARS-CoV-2 infections Subtypes susceptible System tissue tissues Transporting Tumor upregulated were used
[DOI] 10.18632/aging.203229 PMC 바로가기 [Article Type] Research Paper

Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19

Roux-en-Y 위 우회는 피하 백색 지방 조직에서 안지오텐신 전환 효소 2(ACE2) 유전자 발현을 하향 조절합니다: 심각한 COVID-19에 대한 추정 보호 메커니즘

Article

Published on 2021-06-012022-09-11
Journal: Obesity surgery [Category] SARS, 유전자 메커니즘,

[키워드] ACE-2 ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adipose Adipose tissue Against age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bariatric surgery benefit biopsies biopsy BMI bypass Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 expressed expression Gastric Gene Expression Omnibus GEO logFC Microarray microarray data obese obesity progression protective mechanism receptor SARS-CoV-2 searched severe acute respiratory syndrome Coronavirus severe coronavirus disease Sex significant decrease significantly lower Subcutaneous subjects SWAT tissue white women
[DOI] 10.1007/s11695-021-05271-7 PMC 바로가기 [Article Type] Article