Screening of Gene Expression Markers for Corona Virus Disease 2019 Through Boruta_MCFS Feature SelectionBoruta_MCFS 기능 선택을 통한 코로나 바이러스 질병 2019에 대한 유전자 발현 마커 스크리닝Article Published on 2022-06-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] addition Analysis analyzed bioinformatics biological function Biomarker Biomarkers center Classifier Corona COVID-19 diagnosis of COVID-19 disease expression data Feature selection Gene Expression gene expression markers Gene ontology Genes genomes Improving Kyoto limitation network analysis outbreak pandemic Pathways positive positive sample Precision problem protein-protein interaction random Random forest random forest classifier reduction SARS-CoV-2 virus screened Screening selected Selection signaling pathway signaling pathways test results Virus Disease was performed Wuhan Wuhan, China [DOI] 10.3389/fpubh.2022.901602 PMC 바로가기 [Article Type] Article
Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation척수결핵에서 COVID-19 관련 단백질의 메커니즘: 면역 조절 장애Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Accuracy Analysis AUC B cell B cells bioinformatics C-index calculated calibration curve Cell clinical Clinical data collected coronavirus disease COVID-19 degree Diagnosis differentially expressed dysregulation enrichment analysis expression external validation Factor Gene ontology immune Immune cell immune cells immune dysregulation immune genes immune mechanism indicated Intersection intervertebral intervertebral disc involved KEGG KEGG pathway low expression Lymphocytes MCC mechanism mechanisms negative correlation nine nomogram PPI predicted Predictive Protein protein-protein interaction Proteins risk ROC Curve RPL19 significantly lower spinal spinal tuberculosis. suppress tissue tissues training set Tuberculosis was used were used [DOI] 10.3389/fimmu.2022.882651 PMC 바로가기 [Article Type] Article
Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3임상 데이터 마이닝은 IL-6/STAT3에 대한 이중 결합에 의해 중간 정도의 CovID-19에 대한 잠재적 인 허브 쌍으로 간카오-밴 내증을 밝혀냅니다.Article Published on 2022-06-012022-08-31 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료제, [키워드] activator Analysis applied association benzyl binding Bioinformatic Chinese Chinese medicines (CMs) clinical clinical records Commission coniferin coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokine storm Data mining Defense demonstrated dual FIVE Frequency Gancao-Banxia Gene ontology genomes group highest IL-6 immune response immune responses indicated Inflammatory response ingredient inhibit interleukin interleukin-6 Interleukin-6 (IL-6) KEGG Kyoto licochalcone a Medicine Moderate COVID-19 moderate COVID-19 patients molecular docking multisite network network pharmacology Pathways patients piperazine potential mechanisms PPI protein-protein interaction provided quercetin quinone Radix reveal SARS-CoV-2 signal Signal transducer and activator of transcription Signal transducer and activator of transcription 3 (STAT3). signaling pathways STAT3 Support target targets the cytokine storm therapeutic efficacy therapy Transcription Viral were used [DOI] 10.1016/j.compbiomed.2022.105457 PMC 바로가기 [Article Type] Article
Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 PatientsHERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다Article Published on 2022-05-072022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate activated Affect antiviral immunity blood sample Blood samples Cell cGAS chromosome collected COVID-19 COVID-19 patient COVID-19 patients distribution expressed expression Gene ontology Genes GO analysis healthy healthy controls HERV HERV-K HERV-K (HML-2) HML-2 Host human body IFIT1 IFN-I IFNB1 infected with SARS-CoV-2 Interaction interferon ISG15 mapped marker Next-generation sequencing pathway Patient qPCR regulate SARS-CoV-2 secretion STING Vero Vero cells was performed [DOI] 10.3390/v14050996 PMC 바로가기 [Article Type] Article
Tracing the SARS-CoV-2 infection on the ocular surface: Overview and preliminary corneoscleral transcriptome sequencing안구 표면의 SARS-CoV-2 감염 추적: 개요 및 예비 각막 공막 전사체 시퀀싱Article Published on 2022-04-012022-09-11 Journal: Experimental eye research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] absence ADAMTS4 Analysis AQP5 associable caused Cluster Clusters component Cornea Corneal Corneoscleral ring COVID-19 CTRL Cytokines DEGs differentially expressed gene Differentially expressed genes Donor down-regulated gene down-regulated genes enrichment analysis Eye bank gene expression profile Gene ontology Genes genomic genomic RNA GO analysis GO term IL6 Illumina inactive indicated infected individual infected individuals Infection interferon interferon pathway ISG ISG15 ISGs Local Manifestations MMP1 modulation molecular mechanism molecular mechanisms ocular Ocular surface pathway PCA PCA analysis performed Perturbation positive Post-mortem principal Principal component principal component analysis proinflammatory cytokines Protective qRT-PCR RNA RNA-sequencing RSAD2 SARS-CoV-2 SARS-CoV-2 RNA several gene several genes Support tears the interferon the SARS-CoV-2 tissue tracing transcriptional Transcriptome transcriptome analysis transcriptome sequencing virus was performed [DOI] 10.1016/j.exer.2022.108975 PMC 바로가기 [Article Type] Article
Bioinformatics analysis of potential therapeutic targets for COVID-19 infection in patients with carotid atherosclerosisResearch article Published on 2022-04-012022-10-05 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Analysis association Atherosclerosis bioinformatics Brain carotid Carotid atherosclerosis cause Cell conditions connection country COVID-19 COVID-19 infection data-set dataset determine Differentially expressed genes disease drug elevated Gene ontology Health hub gene identify increased mortality Infection New coronavirus pathway Patient patients patients with COVID-19 Pneumonia Potential potential therapeutic target protein–protein interactions regions Result risk risk factor SARS-CoV-2 severe disease stroke susceptibility synergistic therapeutic agent [DOI] 10.1016/j.jiph.2022.03.004 [Article Type] Research article
Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2회복기 인간 면역 혈장 유래 엑소좀에 대한 전임상 연구: SARS-CoV-2에 대한 오믹스 및 항바이러스 특성Article Published on 2022-03-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] biochemical convalescence plasma convalescent convalescent plasma COVID-19 COVID-19 pandemic Efficacy Exosome Exosomes Extracellular extracellular vehicles (EVs) Extracellular vesicles Gene ontology Good good manufacturing practice Human immune measure Ministry of Health passive immunity Practice Preclinical property SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Society Support Treatment Turkish Red Crescent Viral viral treatment. [DOI] 10.3389/fimmu.2022.824378 PMC 바로가기 [Article Type] Article
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients통합 멀티오믹스 및 in silico 분석은 경증 및 중증 COVID-19 환자에서 ARHGEF1 및 선별된 길항제의 역할을 밝혔습니다.Article Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anticancer Antiviral ARHGEF1 association Biotechnology caused center co-expression co-expression network Compound computational tool computational tools coronavirus COVID-19 database DEGs determine differentially expressed gene Differentially expressed genes disease effective therapy ENhance enrichment expressed expression profile gene co-expression network Gene ontology group guanine identify in silico analysis In silico methods in vitro in vivo infected patients inherent Medicines messenger Messenger RNA Mild molecular molecular docking molecular dynamics MSI-DEGs nucleotide number of infected Ontology overlapping pathogenic pathway patients worldwide protein-protein interaction rapid increase required Research SARS-CoV-2 SARS-CoV-2 patients screened severe acute respiratory syndrome Coronavirus severe COVID-19 patient Severity of infection stratified target therapeutic drug therapeutic efficacy therapeutic target therapy virus [DOI] 10.1002/jcb.30213 PMC 바로가기 [Article Type] Article
Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis생물정보학적 분석을 통한 제2형 당뇨병 심장의 핵심 유전자 및 주요 기능 식별Endocrinology Published on 2022-02-152022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Acute cardiac injury Analysis Autopsy Bioinformatic bioinformatic analysis bioinformatics calpain calpain small subunit 1 (capn4) CAPNS1 cardiac cardiac injury conducted COVID-19 cytoplasmic Cytoscape dataset datasets dead DEGs DESeq2 develop diabete diabetes differentially expressed gene Differentially expressed genes down-regulated endopeptidase event events exhibited expression profile expression profiles function functions Gene ontology healthy heart hearts highlight homologous Hospitalized Human hydrolysis hydrolyzed identification identify Infection Interaction Kyoto leads less mechanism membrane mice Mitochondria molecular Mybpc3 Myocardium NCBI-Gene NCBI-GEO nuclear translocation overlapping pathogenic pathway patients with SARS-CoV-2 performed PPI PPI network prognostic progression protein-protein interaction reduced RNA-sequencing SARS-COV-2 infection self-protective role Serine Signaling significantly significantly increased small subunit specimen substrate syndrome T2D therapy Tnni3 Transcription transcriptional change transcriptional level Transcriptional upregulation transcriptomics Type type 2 diabetes unique up-regulated with COVID-19 [DOI] 10.3389/fendo.2022.801260 PMC 바로가기 [Article Type] Endocrinology