A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to NeuroinflammationT 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다Research Article Published on 2016-07-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1 [DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article