Modeling the epidemiological impact of the UNAIDS 2025 targets to end AIDS as a public health threat by 2030Research Article Published on 2021-10-182022-10-29 Journal: PLoS Medicine [Category] Coronavirus, MERS, SARS, [키워드] accelerate AIDS applied build checked contributed country Coverage COVID-19 creating cumulative death deaths declining Effect effort eliminating Epidemic epidemiological estimate expired Gender global analysis global effort Goal Health HIV HIV infection HIV/AIDS Impact include Infection infections Intervention intervention effect limitation mathematical Model modeling OPTIMA PLHIV populations Progress public health threat reduce reducing regions required researcher resource Result selected Support Surveillance target targets Treatment treatment interventions with HIV [DOI] 10.1371/journal.pmed.1003831 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2: Current trends in emerging variants, pathogenesis, immune responses, potential therapeutic, and vaccine development strategiesReview Published on 2021-10-162022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] Abstract ACE-2, Angiotensin-converting enzyme 2 AKI, acute kidney injury Ang II, Angiotensin II BALF, Broncho alveolar lavage fluid cGMP, Good Manufacturing Practice Characteristics coronavirus disease 19 COVID-19 COVID-19 infection COVID-19, Coronavirus disease of 2019 CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRS, Cytokine release syndrome CT, Computed tomography CT, Cycle threshold current Cytokine storm DENV, dengue virus develop diagnostic tests dimension drugs emerging variants FDA, Food and Drug Administration FNR, False‐negative rate Genome GGOs, Ground-glass opacities global effort HAT, Human airway trypsin-like protease health emergency Health Organization HIV, Human immunodeficiency virus IBV, infectious bronchitis virus ICU, Intensive care unit IL, interleukin immune response immune responses Immunity include Infection International JEV, Japanese encephalitis virus lack LAMP, Loop-mediated isothermal amplification LF, Lactoferrin mechanism MIP1α, Macrophage inflammatory protein 1α MRI, Magnetic resonance imaging MSC, Mesenchymal Stem Cells Mutation mutations NCD, Newcastle disease virus new virus NP, nasopharyngeal NSPs, Nonstructural proteins OP, Oropharyngeal pandemic Pathogenesis pathogenicity Potential treatment Prevent problem RAS, Renin-angiotensin system RBD, Receptor binding-domain RdRp, RNA-dependent RNA polymerases Reinfection Research resulting SARS-CoV SARS-CoV-2 SARS-COV-2, severe acute respiratory syndrome coronavirus-2 severity TGF, Transforming growth factor Th17, T helper 17 the disease the SARS-CoV-2 therapeutic therapy Transmissibility treat Vaccine vaccine candidate Vaccine development Vaccines variant variants variants of SARS-CoV-2 virus VLPs, Virus-like particles VTM, Viral transport medium while WHO WNV, West Nile virus [DOI] 10.1016/j.intimp.2021.108232 PMC 바로가기 [Article Type] Review
From Muscles to Wires: Report of Two Cases and Literature Review on COVID-19 Vaccination and Cardiac Conduction DisturbanceCardiology Published on 2021-10-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] addition cardiac cardiac conductive disturbance conduction coronavirus disease COVID-19 COVID-19 vaccine disease disturbance global effort Health knowledge literature literature review mRNA-based vaccine muscle myocarditis Myopericarditis outcome pandemic pathophysiological mechanism permanent pacemaker implantation (ppm) report reported Research review Side effects suggested Vaccine Vaccines [DOI] 10.7759/cureus.18805 PMC 바로가기 [Article Type] Cardiology
Efficacy of Qingfei Paidu Decoction on Patients with COVID-19 Pneumonia in Wuhan, China: A Propensity Score Matching StudyResearch Article Published on 2021-10-052022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] Administered Analysis Chinese cohorts Combination Coronavirus 2019 COVID-19 criteria death Decoction develop diagnosis of COVID-19 Diseases Effect effective Efficacy eligible participant enrolled febrile global effort groups hazard ratio Hypothesis identify Laboratory matching packaged pandemic participant Patient patients died patients with COVID-19 Pneumonia Primary outcome Propensity score PSM receive reduce Result retrospective risk of death score significantly significantly lower single-center survival TCM treat Treatment Union Hospital was used with COVID-19 Wuhan Wuhan, China [DOI] 10.1155/2021/4303380 PMC 바로가기 [Article Type] Research Article
COVID-19 vaccine hesitancy – reasons and solutions to achieve a successful global vaccination campaign to tackle the ongoing pandemicCOVID-19 백신 망설임 - 진행중인 전염병에 대처하기 위해 성공적인 글로벌 백신 접종 캠페인을 달성하기 위한 이유와 솔루션Article Published on 2021-10-032022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] approach circulation coronavirus disease Coverage COVID-19 COVID-19 vaccination COVID-19 vaccine global effort Government groups Health help Immunity individual Infectious disease knowledge Outbreaks pandemic reservoir resources SARS-CoV-2 threat vaccination vaccination rate Vaccine hesitancy Vaccines [DOI] 10.1080/21645515.2021.1926183 PMC 바로가기 [Article Type] Article
Time to ‘Mind the Gap’ in novel small molecule drug discovery for direct-acting antivirals for SARS-CoV-2Review article Published on 2021-10-012022-10-05 Journal: Current opinion in virology [Category] Coronavirus, SARS, 치료제, [키워드] accelerate asymptomatic to mild benefit clinical trial coronavirus disease COVID-19 Critical direct-acting antiviral Drug discovery duration of symptom early stage effective FDA-approved drug global effort highlight hospitalized patients pandemic Population positive quarantine reduce Safe SARS-CoV-2 Spread susceptible time vaccination viral variant [DOI] 10.1016/j.coviro.2021.06.008 [Article Type] Review article
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants교차 중화 항체는 SARS-CoV-2 잠복 부위에 결합하고 순환 변이체에 저항합니다Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affinity antibodies antibody Antibody therapeutics causative agent circulating SARS-CoV-2 variants circulating variant conserved COVID-19 COVID-19 pandemic cross-neutralizing antibody crystal structure crystal structures disrupt domain epitope Epitopes global effort global efforts isolates Mutation N-terminal domain neutralize Neutralizing antibodies public health RBD Receptor-binding domain recognize sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants several variant several variants the RBD the receptor-binding domain Vaccines variants of SARS-CoV-2 Viral viral infection viral spike virus variants X-ray crystallography [DOI] 10.1038/s41467-021-25997-3 PMC 바로가기 [Article Type] Article
Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination무계대 SARS-CoV-2 게놈의 복제 및 적색 재조합을 사용한 돌연변이 유발Article Published on 2021-09-222022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome Antiviral applied approach BAC Bacterial bacterial artificial chromosome Biology biology of SARS-CoV-2 caused Cell culture chromosome click chemistry clone Cloning Combination concerning contribute coronavirus CoV COVID-19 COVID-19 pandemic disease economic devastation facilitate Features FLAG Frame full-length generate Genetic global effort global efforts incoming viral particles labeling Lambda marker morbidity Mortality nucleocapsid Open reading frame pandemic coronavirus platform powerful tool question recombinant virus Recombination Red red recombination replicated Replication reporter reporter virus respiratory reverse genetics SARS-CoV-2 Severe acute respiratory syndrome Severe Acute Respiratory Syndrome CoV single-cell level spatiotemporal Spread Viral viral particle viral replication Viral RNA viral RNA synthesis virus viruses Visualization [DOI] 10.3390/ijms221910188 PMC 바로가기 [Article Type] Article
All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro ActivityArticle Published on 2021-08-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3CL Protease 3CLpro acid activity all-trans retinoic acid Alpha anti-SARS-CoV-2 antiviral drug antiviral efficacy ATRA calu-3 cells caused circulating variant Compound Concentration conserved Effect FDA-approved drug global effort High Throughput Screening in viral in vitro inhibited inhibitor inhibitory effect pandemic of COVID-19 protease Replication replication of SARS-CoV-2 SARS-CoV SARS-CoV-2 screened Spread target therapeutic [DOI] 10.3390/v13081669 PMC 바로가기 [Article Type] Article
An update on novel approaches for diagnosis and treatment of SARS-CoV-2 infectionReview Published on 2021-08-222022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] approach approved complementary coronavirus disease COVID-19 develop Diagnosis diagnostic diagnostics effort Factor global effort Health help include Medicines Neutralizing Numerous overcome pandemic Population public health Research researcher resource SARS-CoV-2 SARS-COV-2 infection supplementary material the disease Therapeutic approach Treatment Vaccine development Vaccines while [DOI] 10.1186/s13578-021-00674-6 PMC 바로가기 [Article Type] Review