Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and TherapeuticsCOVID-19의 기계론적 모델: 질병 진행, 백신 및 치료제에 대한 통찰력Review Published on 2022-07-012022-09-11 Journal: International journal of antimicrobial agents [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] adaptive antiviral therapeutics antiviral therapy COVID-19 COVID-19 pandemic COVID-19 vaccines Critical develop Effectiveness global effort health system health systems Immunity Immunomodulatory agents impacted IMPROVE Infection innate and adaptive immunity insight mechanism Model outcome pandemic provided Quantitative quantitative systems pharmacology SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variants Significant Therapeutics Transmission Vaccine Vaccines viral dynamics Viral dynamics models. [DOI] 10.1016/j.ijantimicag.2022.106606 PMC 바로가기 [Article Type] Review
Drug repurposing for the treatment of COVID-19COVID-19 치료를 위한 약물 용도 변경Review Published on 2022-07-012022-09-11 Journal: Journal of pharmacological sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료법, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aggravation approved Cancer cardiomyocyte cardiovascular disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diabetes drug Drug repurposing Eco-pharma global effort global efforts heart failure hypertension increase mammalian cells mechanism Mortality NADPH NADPH oxidase outcome Patient prevalent protein-protein interaction Protein–protein interaction receptor receptor potential reported Research risk Safe SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 shown therapeutic therapeutic agent therapeutic agents Transient Transient receptor potential channel. Treatment vaccine-resistant variant Vaccine-resistant variants virus Wuhan Wuhan, China [DOI] 10.1016/j.jphs.2022.04.007 PMC 바로가기 [Article Type] Review
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variantsSARS-CoV-2 변이체의 분자 특성, 면역 회피 및 영향Review Published on 2022-06-282022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accompanied antibody Anxiety benefit Characteristics clinical manifestation clinical manifestations concern COVID-19 COVID-19 pandemic Critical disease disease control drug and vaccine development Evolution exacerbated facilitate feature global effort global efforts global public health Health Organization heterogeneous highlight immune evasion Immunity Impact Infection molecular Mutation omicron pandemic public health Research SARS-CoV-2 variant SARS-CoV-2 variants Spread the SARS-CoV-2 Transmissibility Treatment Treatment effectiveness Vaccine development Vaccines variant variants viral dynamics Viral protein Viral proteins virus genome VoC World Health Organization [DOI] 10.1038/s41392-022-01039-2 PMC 바로가기 [Article Type] Review
Laboratory information management system for COVID-19 non-clinical efficacy trial data코로나19 비임상 유효성 시험 데이터에 대한 실험실 정보 관리 시스템Article Published on 2022-06-282022-09-11 Journal: Lab Anim Res [Category] 비임상, [키워드] accelerated adopted approach benefit biosafety level Biosafety Level 3 body temperature body weight breath can be used Clinical signs collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic data develop Efficacy explosion feasibility global effort global efforts Histopathology information information management interoperability Laboratory Laboratory information management system level 3 management Mortality Multiorgan Non-clinical organ organization Outbreaks pandemic platform producing proliferation Research SARS-CoV-2 shown systemically Therapeutics Trial Vaccine viral replication Viral RNA viral titer [DOI] 10.1186/s42826-022-00127-2 PMC 바로가기 [Article Type] Article
The effectiveness of nutritional interventions on COVID-19 outcomes: A protocol for systematic review and meta-analysisCOVID-19 결과에 대한 영양 중재의 효과 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-06-012022-08-31 Journal: Nutrition and health [Category] MERS, meta-analysis, [키워드] alleviate approach article assessment tool carried case studies Cohort studies Consensus COVID-19 cross-sectional database determine effective intervention effective interventions Effectiveness extraction feature global effort global efforts Google Scholar immune system integrity Intervention Meta-analysis nonrandomized not performed nutrition nutritional intervention nutritional interventions outcome performed post-intervention power protocol provided Randomized reached reason resolved risk of bia Screening searched Support systematic review treat trials Web of Science [DOI] 10.1177/02601060221080241 PMC 바로가기 [Article Type] Article
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Social media and attitudes towards a COVID-19 vaccination: A systematic review of the literatureResearch article Published on 2022-05-202022-10-05 Journal: EClinicalMedicine [Category] 변종, [키워드] Affect Analysis analyzed article association categories CINAHL cofactor coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cross-sectional study domination evaluated event events Evidence excluded finding fluctuation funding global effort global health inclusion criteria individual individuals information limit media moderate NOS outcome Pandemics performed platform positive public health Public health intervention Registered reported Research scale Social behaviors social media social media platforms systematic review vaccination vaccination intention Vaccine Vaccine hesitancy vaccine intention viral infections was used Web of Science [DOI] 10.1016/j.eclinm.2022.101454 [Article Type] Research article
TopHap: rapid inference of key phylogenetic structures from common haplotypes in large genome collections with limited diversityTopHap: 다양성이 제한된 대규모 게놈 컬렉션의 공통 일배체형에서 주요 계통 발생 구조의 신속한 추론Article Published on 2022-05-132022-09-11 Journal: Bioinformatics [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses approach bioinformatics bootstrap build building co-occurrence common variants coronavirus datasets determine develop evaluated evolutionary relationship evolutionary relationships Features fraction Genome genomes genomic global effort Haplotype haplotypes IMPROVE interfere massive Mutation pandemic Phylogenetic phylogenetic inference Phylogenetic relationship Phylogenetic tree phylogenetically Phylogeny produced provided reconstructed SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 phylogeny sequence sequences Sequencing sequencing error sequencing errors severe acute respiratory syndrome Coronavirus signal signal-to-noise ratio strain Strains Structure the SARS-CoV-2 traditional methods variant variants variants of concern [DOI] 10.1093/bioinformatics/btac186 PMC 바로가기 [Article Type] Article
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Tackling the emerging threat of antifungal resistance to human health Reviews Published on 2022-03-292022-10-05 Journal: Nature reviews. Microbiology [Category] 진단, [키워드] Bacterial diagnostics drugs fungal Fungal infection fungi global effort Health highlight hotspot include main mechanism mitigate one health pathogenic populations public health required Research review risk reduction similarity Surveillance therapy Transmission [DOI] 10.1038/s41579-022-00720-1 [Article Type] Reviews