Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibitionSARS-CoV-2 감염은 숙주 세포 대사를 다시 연결하고 잠재적으로 mTORC1 억제에 취약합니다Article Published on 2021-03-252022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Activation Air-liquid interface Alter block carbon caused cell line cell lines change changes COVID-19 COVID-19 patient COVID-19 patients cultures determine Efficacy epithelial epithelial cell epithelial cells Evidence evidence of expression facilitate feasible Glucose Glutamine host cell host cell metabolism increase inhibitor kidney lung lung ALI cultures lung tissue mechanism Mechanisms of disease metabolism mTORC1 Mucosal immunology oxidative pandemic of COVID-19 patients Potential treatment potential treatments pyruvate reduce reduce viral replication Replication required SARS-CoV-2 SARS-COV-2 infection suppresse susceptible TCA cycle therapy TOR signalling Treatment understanding viral infection viral replication [DOI] 10.1038/s41467-021-22166-4 PMC 바로가기 [Article Type] Article
Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID-19 (Review)Review Published on 2021-03-042023-08-30 Journal: International journal of molecular medicine [Category] E형 간염, [키워드] Coronavirus disease 2019 Glutamine Immunity interferon OncoTherad severe acute respiratory syndrome coronavirus 2 Vitamin D Zinc [DOI] 10.3892/ijmm.2021.4844 PMC 바로가기 [Article Type] Review
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2단백질 구조 이질성: SARS-CoV 및 SARS-CoV-2의 주요 단백질 분해효소에 의한 단백질 분해 인식 기반에 대한 가설Article Published on 2021-03-012022-09-11 Journal: Biochimie [Category] SARS, 신약개발, 치료제, [키워드] active site Analysis antiviral drugs antiviral therapeutics appear binding binding site catalytically cleavage cleavage sites competent conformational Conformational selection conformations Drug development enzyme expand explain explanation flexibility Glutamine heterogeneity Hypothesis in viral independent independent of initial insight Ligand ligands M pro methionine modulation N- and C-termini observation observations property protease Protein proteolytic recognize recognizing Replication residue residues reveal SARS-CoV SARS-CoV-2 sequence specificity structural evidence Structure structures substrate substrates Variation viral protease viral replication [DOI] 10.1016/j.biochi.2021.01.010 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host CellsMolecular Biosciences Published on 2021-01-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absence acute respiratory syndrome anabolic approaches biochemical biosynthetic cellular Clinical data complex coronavirus coronavirus disease COVID-19 demonstrated develop dysregulated effort Escalation event Evidence Factor Glucose Glutamine glutaminolysis HIF-1α host cell Hypothesis hypoxia-inducible factor 1-alpha hypoxia-inducible factor-1 alpha in vitro in vivo infect Infection mammalian metabolic metabolic reprogramming metabolism mTORC1 pandemic Pathogenesis Perspective promote PSAT1 Rapamycin Research researcher SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 pathogenesis Support therapeutic transcription factor Treatment viral infection viral infections [DOI] 10.3389/fmolb.2020.627842 PMC 바로가기 [Article Type] Molecular Biosciences
Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen화학유전체 스크리닝에 의해 밝혀진 폐렴구균에서의 아지트로마이신 내성 돌연변이Article Published on 2020-11-192024-07-30 Journal: Microbial Genomics [Category] 폐렴구균 감염증, [키워드] Azithromycin chemical mutagenesis Glutamine Macrolide next generation sequencing resistance Streptococcus pneumoniae [DOI] 10.1099/mgen.0.000454 PMC 바로가기
Opposing functions of Fng1 and the Rpd3 HDAC complex in H4 acetylation in Fusarium graminearumFusarium graminearum의 H4 아세틸화에서 Fng1 및 Rpd3 HDAC 복합체의 반대 기능Research Article Published on 2020-11-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a minor Affect ascomycetes barley Blight blocked characterized Chromatin structure chromosomal region complex complexes component components conidiation Critical Deletion deletion mutant disease elevated ENCODE euchromatin expression level faster filamentous fungi frameshift function functional fungal fungi Fusarium Genes Genetic variations Glutamine growth growth defects growth rate had no HDAC head histone homolog hyphal hypothetical hypothetical protein Infection ING1 inhibitor interact invasive involved minor MOST mutant Mutation nonsense mutation occurred ortholog orthologs pathogenicity Protein reduced reduction in regulate Regulation reported RNA-seq analysis sexual development sexual reproduction significantly strain suppress suppressor Suppressor mutations transcriptional transcriptional regulation unique vegetative growth wheat while yeast [DOI] 10.1371/journal.pgen.1009185 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging Research Published on 2020-10-222022-10-05 Journal: Nature chemical biology [Category] SARS, 변종, 치료제, [키워드] antiviral agent antiviral drug complex COVID-19 COVID-19 infection determine diagnosed diagnostic tests effective antiviral treatment epithelial cell Glutamine half-maximal effective concentration Infection inhibitor MPro nasopharyngeal Novel coronavirus Patient preference probe probes protease Proteases SARS-CoV SARS-CoV-2 SARS-CoV-2 Mpro structural framework substrate targets the SARS-CoV-2 [DOI] 10.1038/s41589-020-00689-z [Article Type] Research
Pharmaconutrition in the Clinical Management of COVID-19: A Lack of Evidence-Based Research But Clues to Personalized PrescriptionReview Published on 2020-09-252022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Administered administration arginine benefit candidate clinical clinical condition Clinical management colds coronavirus disease Coronavirus disease 2019 COVID-19 Critical care determine dose Evidence Fatty acid Glutamine identify imperative intramuscularly management nutrition occur oral Patient Polyunsaturated prescription progression Research SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severe deficiency Supplementation symptoms of COVID-19 Treatment utility Vitamin C [DOI] 10.3390/jpm10040145 PMC 바로가기 [Article Type] Review
Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)Research Published on 2020-06-252022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] ACE inhibitors ACE1 ACE2 ACE2 binding acute respiratory syndrome animal model antibiotic antiviral agent applied artificial intelligence attenuate benefit binding binding affinity bioinformatics blocking virus entry caused Cell Compound computational approach Computational biology coronavirus Coronaviruses COVID-19 DCT disease-associated drug drug therapy Effect Effects emerging disease Emricasan FDA approved drug Fosamprenavir Gene Expression gene expression pattern global pandemic Glutamine glutathione highlight identify independent induce Infection Patient platform precursor Prevent protective effect Result ruxolitinib SARS-CoV SARS-CoV-2 second specificity technology therapeutic agent TMPRSS2 translation Vitamin E while [DOI] 10.1186/s12967-020-02430-9 PMC 바로가기 [Article Type] Research