Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogrammingIRAK4의 억제는 SARS-CoV-2 스파이크 단백질 유도 대식세포 염증 및 해당과정 재프로그래밍을 조절하지 못함Article Published on 2022-05-192022-09-11 Journal: Cellular and Molecular Life Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 activate AKT baseline blockade CCL2 cells citrate counteract Critical dysregulated ERK expression Glycolysis human SARS-CoV-2 Hyperactivation IL-6 IL-8 impair independent Inflammatory Inflammatory marker inflammatory markers inhibition inhibitor Innate immunity irak4 IRAK4 inhibitor IRF5 IRF7 knockdown Lactate LDHA Macrophage macrophages metabolic activity mitochondrial Mitochondrial oxidative phosphorylation molecular mechanism monokines murine models NF-κB NF-κB activation oxidative oxidative phosphorylation phenotype Phosphorylation promoted Protein reduction response responsible reversal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 patient severe COVID-19 patients shown Signaling siRNA spike Spike protein succinate suppression Therapeutic strategies therapy TLR TLR-mediated TLR2 TLR7 TLRs TLRs. TNFα treated Treatment triggered without affecting [DOI] 10.1007/s00018-022-04329-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGEArticle Published on 2022-05-062023-07-09 Journal: Viruses [Category] COVID19(2023년), [키워드] Glycolysis Inflammation metabolic reprogramming mitochondria. RAGE SARS-CoV-2 Tepp-46 [DOI] 10.3390/v14050983 PMC 바로가기
2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart2 deoxy-D-glucose는 심장의 미토콘드리아 호흡 사슬을 증가시킵니다.Article Published on 2022-04-272022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 비임상, [키워드] 2-deoxy-D-glucose accompanied appear approval benefit breath caused cell metabolism clinical trial COVID-19 COVID-19 disease cultured cell cultured cells detrimental effect disease elevated explain fibrosis Glucose Glycolysis heart hypertrophy in vivo increase in India induce metabolism mice mitochondrial Mitochondrial function murine occur opposite oxidative patients with COVID-19 pleiotropic effect Pleiotropic effects Propagation proteome represse Respiration respiratory chain restrict SARS-CoV-2 infected cells SARS-COV-2 infection stimulate Treatment vacuolization viral replication virus while [DOI] 10.1038/s41598-022-10168-1 PMC 바로가기 [Article Type] Article
Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions해당 억제제 2-deoxy-d-glucose는 숙주 세포에서 SARS-CoV-2 증식을 약화시키고 자손 비리온의 감염 가능성을 약화시킵니다Article Published on 2022-04-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Analysis attenuate Cell COVID-19 COVID-19 patients CPE Cytopathic effect Effect evaluated examined fluorescent Glucose Glycolysis glycosylation Herpe herpes host cell host cells Infection infective inhibited inhibitor investigated mass spectrometry metabolism nucleocapsid patients phenotype produced progeny virion progeny virions Protein protein expression RBD RdRP RdRp genes Receptor binding domain Receptor-binding domain reduced required resulting RT-PCR SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein the receptor-binding domain the spike protein treated Trial Unglycosylation. Vero E6 VERO E6 cells virion virus multiplication was performed [DOI] 10.1016/j.lfs.2022.120411 PMC 바로가기 [Article Type] Article
Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitroarticle Published on 2022-03-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] 2,3-BPG 2,3-DPG Glycolysis Host–parasite interactions malaria pyruvate kinase deficiency red blood cell [Article Type] article
SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysisSARS-CoV-2 스파이크 L452R 돌연변이는 Omicron 변이체 융합성 및 감염성 및 숙주 해당작용을 증가시킵니다Letter Published on 2022-03-092022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, [키워드] Genetics research Glycolysis Host increase L452R Medical genetics Mutation omicron SARS-CoV-2 spike variant [DOI] 10.1038/s41392-022-00941-z PMC 바로가기 [Article Type] Letter
Modulation of Macrophage Immunometabolism: A New Approach to Fight InfectionsImmunology Published on 2022-01-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulated amino acid metabolism Bacterial contribute Defense develop drug Evidence Extracellular fatty acid oxidation function Glycolysis Host immune function Immunity immunometabolism Infection infections innate immune cell Macrophage macrophage activation metabolic pathway New pentose phosphate pathway phenotype potential therapy regulate respond SARS – CoV – 2 SARS-CoV2 infection Therapeutic strategies Therapeutics viral infection [DOI] 10.3389/fimmu.2022.780839 PMC 바로가기 [Article Type] Immunology
CD14 Is Involved in the Interferon Response of Human Macrophages to Rubella Virus InfectionArticle Published on 2022-01-262023-08-29 Journal: Biomedicines [Category] E형 간염, [키워드] chemokine cytokine extracellular flux analysis Glycolysis [DOI] 10.3390/biomedicines10020266 PMC 바로가기 [Article Type] Article
Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients장 미생물 변동 및 장 장벽 기능 장애는 Covid-19 환자에서 숙주 면역 항상성과 관련이 있습니다.Research Article Published on 2022-01-202022-09-10 Journal: BMC Medicine [Category] SARS, 치료기술, [키워드] abundance affecting alteration Altered approach Bacteria Bacteroide Bacteroides Bifidobacterium longum Biomarker Blood blood sample Blood samples Burkholderia CAG characterized circulating controls COVID-19 COVID-19 patient COVID-19 patients detectable Dysbiosis dysfunction example feature Fecal sample fecal samples fermentation gastrointestinal symptoms Glycolysis Gut Gut barrier gut microbiome gut microbiota Host Host immune response immune cells Immune homeostasis immune response Infectious disease Infectious diseases Inflammation Influenza Interaction lipopolysaccharide Manifestations metagenomic Metaproteomic microbial microbial community Microbiome microbiota non-infected parameter pathogenic pathophysiology pathway Patient patients Protein respiratory Result SARS-CoV-2 suggested supplementary material transcriptional profile transcriptional profiles virulence genes were measured [DOI] 10.1186/s12916-021-02212-0 PMC 바로가기 [Article Type] Research Article
Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cellsResearch Published on 2022-01-182022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] activate Activation acute respiratory syndrome caused Cell cellular coronavirus coronavirus disease COVID-19 Efficacy endogenous Fatty acid fatty acids Glutamine Glycolysis Host Infection inhibitor Intervention introduced investigated metabolism metabolite MHV Mitochondria mitochondrial metabolism mouse hepatitis mouse hepatitis virus NAD+ nicotinamide riboside NR pandemic pyruvate Replication reported Result SARS-CoV-2 significantly supplementary material suppress suppresse suppressed survival TCA cycle therapeutic Therapeutic molecule therapy for COVID-19 Transport viral replication virus virus-infected cell [DOI] 10.1186/s13578-021-00740-z PMC 바로가기 [Article Type] Research