Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognitionArticle Published on 2020-09-142022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 3D structure ACE2 receptor binding Adaptive immune response antibody Antigen antigenicity complexes determine domain glycan glycans glycoprotein glycosylation Golgi HEK293 HEK293 cells HLA immune immunology Impact implication leukocyte Modification modulating molecular molecular weight notable peptide produced Protein Protein structure predictions reported representing reveal S glycoprotein S protein S trimer SARS-CoV-2 shielding Spike protein Structure the SARS-CoV-2 the SARS-CoV-2 virus Vaccine viruses [DOI] 10.1038/s41598-020-71748-7 PMC 바로가기 [Article Type] Article
Expansion of Single Cell Transcriptomics Data of SARS-CoV Infection in Human Bronchial Epithelial Cells to COVID-19Research Published on 2020-07-232022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Analysis applied association Atla B- and T-cells bronchial bronchial epithelial cell bronchial epithelial cells cell line coronavirus coronavirus disease COVID-19 COVID-19 patients Critical Cytokine storm database dendritic cells downregulated downregulated gene expand expansion expected functional gene Gene ontology Golgi highest homolog Human Hyperactivation immune system immunological Immunological regulations infected cell Ontology overlap pathway phosphatase platform Proinflammatory cytokine proinflammatory cytokines Protein PTEN Reactome pathways Regulation Result SARS-CoV SARS-CoV infection SARS-CoV-2 secretion Severe acute respiratory syndrome shown signaling pathways similarity Single Cell Spread System biology to define Transcriptome transcriptomics Transport Vaccine Wuhan, China [DOI] 10.1186/s12575-020-00127-3 PMC 바로가기 [Article Type] Research
Janus sword actions of chloroquine and hydroxychloroquine against COVID-19코로나19에 대한 클로로퀸과 하이드록시클로로퀸의 야누스 칼 액션Article Published on 2020-07-032023-07-01 Journal: Cellular signalling [Category] SARS, 말라리아, [키워드] Chloroquine COVID-19 de-acidification endolysosome Golgi Hydroxychloroquine [DOI] 10.1016/j.cellsig.2020.109706 PMC 바로가기 [Article Type] Article
Shigella impairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and T cell receptor vesicular traffickingarticle Published on 2020-05-312024-09-01 Journal: Cellular Microbiology [Category] 세균성이질, [키워드] Actin cell polarisation Golgi immunological synapse Rab proteins Shigella T cell activation T3SS effectors TCR vesicular trafficking [Article Type] article
A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi TransportArticle Published on 2019-06-032023-08-30 Journal: Developmental cell [Category] E형 간염, [키워드] AMPK anterograde trafficking collagen endothelial cells GBF1 Golgi Hemostasis organelle size secretion von Willebrand factor [DOI] 10.1016/j.devcel.2019.04.006 PMC 바로가기 [Article Type] Article
The Infectious Bronchitis Coronavirus Envelope Protein Alters Golgi pH To Protect the Spike Protein and Promote the Release of Infectious VirusArticle Published on 2019-03-132023-06-14 Journal: Journal of Virology [Category] MERS, [키워드] coronavirus E protein Golgi oligomers pH viroporin [DOI] 10.1128/JVI.00015-19 PMC 바로가기
The Accessory Protein ORF3 Contributes to Porcine Epidemic Diarrhea Virus Replication by Direct Binding to the Spike ProteinArticle Published on 2018-07-282022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein ORF3 binding affinity Cell Cell culture cells confocal microscopy cytoplasm demonstrated diarrhea Direct Endoplasmic reticulum epidemic diarrhea expression expression plasmid FLAG flow cytometry full-length Golgi Golgi apparatus infected cells Interaction N-terminal Neonatal ORF3 ORF3 protein pathogen PEDV performed Porcine epidemic diarrhea virus Protein regulate Replication responsible S protein Spike protein Structure subcellular localization the S protein the Spike Viral proteins virus virus replication watery [DOI] 10.3390/v10080399 PMC 바로가기 [Article Type] Article
Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus InfectionArticle Published on 2017-09-052022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] alpha-coronavirus approach cause characterization coronavirus Course CoV drastic electron microscopy Endoplasmic reticulum epidemic diarrhea examined form gastroenteritis Golgi high mortality host cell membrane immature induced Infection lifecycle membrane membrane rearrangement Microscopy organelle PEDV promote Rearrangement Replication resulting secretory pathway similarity TGEV Vesicle viral particle virus [DOI] 10.3390/v9090251 PMC 바로가기 [Article Type] Article
Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7bResearch Article Published on 2017-08-312022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] accessory protein addition approach C-terminal C-terminus cause cells cellular cellular trafficking changes in cleavage site Control coronavirus coronavirus accessory proteins Effect Endoplasmic reticulum expressing expression Feline coronavirus Feline infectious peritonitis FIVE FLAG-tagged form functions Genetic glycosylation Golgi Golgi retention identification information investigated motif mutant N-terminal predicted processed Protein Proteins provide purified recombinant residues resulting retained retention signal reverse genetics secretion sequence Sequence analysis Substitution virus [DOI] 10.1099/jgv.0.000879 PMC 바로가기 [Article Type] Research Article
Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in InfancyNBAS의 이대립유전자 돌연변이는 유아기에 발병하여 재발성 급성 간부전을 유발합니다Report Published on 2015-07-022022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] acute infantile liver failure acute liver failure ALF Analysis biallelic mutation biallelic mutations cause childhood compound heterozygous mutation compound heterozygous mutations condition Endoplasmic reticulum Exome exome sequencing Fever fever-dependent RALF FIVE Golgi Immunoblot analysis individual infancy interaction partner involved life-threatening emergency liver liver failure molecular cause mutant fibroblast mutant fibroblasts NBAS Onset protein level RALF Recurrent reduced retrograde transport Sanger sequencing triggered [DOI] 10.1016/j.ajhg.2015.05.009 PMC 바로가기 [Article Type] Report