Overlapping host pathways between SARS-CoV-2 and its potential copathogens: An in silico analysisSARS-CoV-2와 잠재적 copathogens 간의 중복 호스트 경로: 실리코 분석Article Published on 2020-12-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] analyses bacterial pathogen Biomarker candidate Candidates Coinfection COVID-19 cohort COVID-19 phenotypes detect determinant determine drug design EBV enrichment analysis Enrichr epithelial false discovery rate FDR Gene Expression Gene Expression Omnibus gene network gene set enrichment analysis GEO GSEA HIV1 Host host gene IAV immune cells in silico analysis increasingly Infection infections Interaction involved material Meta-analysis overlap pathogen Pathogens pathway Peripheral blood Perturbation platform provide reported RSV SARS-CoV-2 SARS-COV-2 infection significantly statistically significant System Systems biology transcriptomic transcriptomics Viral viral infection were used [DOI] 10.1016/j.meegid.2020.104602 PMC 바로가기 [Article Type] Article
Comprehensive assessment of side effects in COVID-19 drug pipeline from a network perspectiveResearch article Published on 2020-11-012022-10-05 Journal: Food and chemical toxicology : an international jo [Category] SARS, 신약개발, 치료제, [키워드] adverse event Analysis antiviral therapeutics approach approaches association clinical evidence Clinical practice clinical trials CMap Comprehensive coronavirus disease Course COVID-19 COVID-19 drug drug drugs FDA food gene-set enrichment analysis global public health GSEA human tissue identify labeling lung Network proximity occurred OpenVigil patients with COVID-19 performed Perspective pharmacovigilance provide renal Safe safety profile SARS-CoV-2 Side effect therapeutic agent tissues Toxicity Treatment [DOI] 10.1016/j.fct.2020.111767 [Article Type] Research article
Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer AnalysisMolecular Biosciences Published on 2020-10-232022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 expression ACE2 gene Affect Analysis analyzed B cell breast cancer patients Cancer cancer cell lines cancer patient cancer type cancers carried CD4+ T cells CD8+ T cells China Clinical prognosis conducted Coronavirus disease 2019 correlated correlation COVID-19 COX dendritic cells determine DNA elevated evaluated expressed expression expression level Frequency Functional enrichment analysis global pandemic GSEA HLA gene immune immune infiltration indicated infiltrating investigated Kaplan-Meier lung Macrophage macrophages malignant malignant tumor medium mismatch Mutation Neutrophils not correlated observational study organ Pan-cancer analysis pathway patients with pneumonia positive correlation Prognosis receptor regression analysis repair reported Result risk factor SARS-CoV-2 significantly Spread survival systematic analysis TCGA tested the SARS-CoV-2 virus tissues TMB Tumor tumors with COVID-19 [DOI] 10.3389/fmolb.2020.569414 PMC 바로가기 [Article Type] Molecular Biosciences
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019Genetics Published on 2020-09-302022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] addition Analysis analyzed association Atla changes in conducted coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-2019 database dataset elevated enrichment analysis examined expression expression level Gene expression profiling GEO GSEA HPA Human immune Immune cell immune cell type immune infiltration in vitro in vivo Infection malignancy marker Methylation Occurrence Ontology Pathway analysis positively correlated PPI Prognosis prognostic biomarker promoter Prostate prostatic adenocarcinoma protein-protein interaction resource serine proteases shown significantly increased survival susceptible the microarray tissue TMPRSS2 TMPRSS2 expression transmembrane serine protease Type type 2 transmembrane serine protease [DOI] 10.3389/fgene.2020.575770 PMC 바로가기 [Article Type] Genetics
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer PatientsResearch Paper Published on 2020-07-062022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome addition Bioinformatic Cancer cancer patient caused cell line Colon coronavirus coronavirus disease correlated correlation COVID-19 digestive enrichment analysis estimation expressed fetal GSEA healthy Immune cell infiltration immune infiltration Infection investigated male maternal-fetal transmission pathway performed Profiling reproductive SARS-CoV-2 SARS-COV-2 infection severity signaling pathways significantly suggested susceptibility tissue tissues Tumor Urinary tract [DOI] 10.7150/ijbs.48639 PMC 바로가기 [Article Type] Research Paper
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli CellsArticle Published on 2020-04-092022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 category cell entry receptor China coronavirus COVID-19 patient digestive downregulated enrichment Evidence expression pattern Gene ontology GO term GSEA Human indicate Infection male Novel coronavirus pathophysiology Presence Profiling provided rapidly spreading disease reproductive SARS-CoV SARS-CoV-2 SARS-COV-2 infection scRNA-seq sequence similarity Sertoli Sertoli cells single-cell transcriptomes spermatogonia target Teste Transmission Wuhan [DOI] 10.3390/cells9040920 PMC 바로가기 [Article Type] Article
TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cellsArticle Published on 2018-01-012023-06-14 Journal: European Journal of Immunology [Category] Fulltext, 신종인플루엔자, [키워드] GSEA influenza A Lung infection T cells TCR-pMHC TGF-β, Transcriptome Trm [DOI] 10.1002/eji.201747174 PMC 바로가기