Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineagesArticle Published on 2022-09-012022-11-16 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated African amino acid substitution Analysis AY.1 B.1.617.2 B.1.621 binding binding interaction China Combination complexes COVID-19 Delta docking domain Effect exhibited Factors Genetic hACE2 Host human Angiotensin-converting enzyme Interaction investigated Latin Lineage missense variant Missense variants MM/GBSA molecular docking molecular docking analysis molecular dynamics Molecular dynamics simulation MOST Mutation mutations non-Finnish European omicron Population populations predict prevalent protein stability rate of infection RBD Receptor binding risk SARS-CoV-2 SARS-CoV-2 RBD South Asian spike glycoprotein suffered the SARS-CoV-2 Transmissibility variant variants variants of concern viral variant virus was performed Wuhan [DOI] 10.1016/j.compbiomed.2022.105903 PMC 바로가기
Stapled peptides as potential inhibitors of SARS-CoV-2 binding to the hACE2 receptorReview Published on 2022-09-012023-07-08 Journal: Journal of peptide science : an official publication of the European [Category] COVID19(2023년), [키워드] COVID-19 hACE2 inhibitor peptide SARS-CoV-2 stapling therapeutic [DOI] 10.1002/psc.3409 PMC 바로가기 [Article Type] Review
A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 VaccineArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition adenovirus-based Administered administration ambient Antibody titer bacteriophage CRISPR engineering bacteriophage T4 mucosal platform BALB/c broad immunity to SARS-CoV-2 variants bronchoalveolar lavage specimen bronchoalveolar lavage specimens caused CD4 CD8 Cell-mediated immune responses cellular immune responses Complete COVID COVID-19 CRISPR cytokine death delta variant dose drug effective elicited enzyme Epidemic exhibited exterior food generate globe gut microbiota hACE2 humoral Immunity induce Infection injected interior intramuscularly intranasal intranasally lung lesion mice mouse-adapted SARS-CoV-2 mRNA mucosal nasal needle needle-free intranasal vaccine not affect nucleocapsid protein omicron other respiratory infection pandemic Pathogens phage T4 platform predicted Prevent provide provided response responses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secretory IgA sera spike sterilizing immunity. T cell temperature the United State the vaccine Transgenic mouse Transmission trimer Vaccine variants Viral transmission Virus neutralization virus-neutralizing antibody World Health Organization [DOI] 10.1128/mbio.01822-22 PMC 바로가기
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesisArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect Alter antibodies antibody binding binding affinity calculated cells change changes changes in Characteristics complexes contagious COVID-19 pandemic distribution docking domain drug design electrostatic electrostatic interaction ENhance entry of SARS-CoV-2 epitope hACE2 HSPGs human Angiotensin-converting enzyme hypothese Hypothesis immune evasion Invasion involved molecular mechanism mutant Mutation mutations neutralizing antibody occurred omicron pathophysiological Point mutation positive Protein Proteoglycan RBD RBD mutation RBD mutations residue S protein S trimer SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variants strain surface the RBD Therapies Vaccine development variant variant strain viral fitness viral infectivity virulence virus virus receptor [DOI] 10.3389/fpubh.2022.952916 PMC 바로가기
Butein as a potential binder of human ACE2 receptor for interfering with SARS-CoV-2 entry: a computer-aided analysisSARS-CoV-2 진입을 방해하기 위한 인간 ACE2 수용체의 잠재적 결합제로서의 부테인: 컴퓨터 지원 분석Article Published on 2022-08-242022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin antiviral activity atomic level Butein clinical trials Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dietary supplement drug candidate effective examined hACE-2 hACE2 hACE2 receptor herbal compound herbal compounds host cell host cells human ACE2 receptor human Angiotensin-converting enzyme In silico methods Infection infections Interaction interfere molecular molecular docking molecular dynamics Molecular modeling natural natural products pathogen Pathogens physicochemical Phytoconstituents profile receptor Recognition researcher SARS-CoV-2 screened selected severe acute respiratory syndrome Coronavirus shown Spike protein subset target protein therapeutic these compound these compounds viral entry viral particle Viral particles zoonotic [DOI] 10.1007/s00894-022-05270-0 PMC 바로가기 [Article Type] Article
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes Research Published on 2022-08-172022-10-05 Journal: Communications Biology [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 attenuate cause coronavirus COVID-19 COVID-19 patients cytopathic effects Deprivation Evidence exacerbated expressed expressing Fatty liver full-length Glycolysis hACE2 hepatic dysfunction hepatocyte hepatocytes Human humanized hyperglycemia immune response include increase Infection infection with SARS-CoV-2 Inflammation inhibition Injury metformin methionine mice mitochondrial Multi-organ damage Patient promote pseudotyped viral particles pseudovirus RBD Receptor binding domain reduce renin-angiotensin system SARS-CoV-2 steatosis susceptibility susceptible therapeutic option Toxicity type 2 diabete viral particle [DOI] 10.1038/s42003-022-03789-9 [Article Type] Research
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapiesB 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination Vaccine design virus infection [DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article