Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19Enoxaparin은 COVID-19에 대한 유망한 약물 조합인 TMPRSS2의 알파-1-항트립신 억제를 증가시킵니다.Article Published on 2022-03-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법, [키워드] affected alpha-1-antitrypsin anti-inflammatory activity antitrypsin Cell cells cleave complex consequence Coronavirus infection COVID-19 crystal structure drug combination ENhance enoxaparin epithelial cell epithelial cells hAEC HCoV HCoV-229E HEK293T cell HEK293T cells heparin human coronavirus human coronavirus 229E immunostaining Infection Inflammatory less molecular nafamostat Neutralizing nucleocapsid protein overexpressing Plaque assay primary human airway Primary human airway epithelial cells quantified reactive required SARS-CoV-2 SARS-CoV-2 mutations Serine serine protease severe COVID-19 Spike protein the cell the spike protein therapy TMPRSS2 TMPRSS2 inhibitor Treatment Viral viral entry virus was determined [DOI] 10.1038/s41598-022-09133-9 PMC 바로가기 [Article Type] Article
Validating and optimizing the method for molecular detection and quantification of SARS-CoV-2 in wastewater폐수에서 SARS-CoV-2의 분자 검출 및 정량화 방법 검증 및 최적화Article Published on 2022-03-152022-09-11 Journal: The Science of the total environment [Category] MERS, SARS, 진단, 치료기술, [키워드] 229E best changes in Community community infections coronavirus COVID-19 COVID-19 disease cycle threshold disease DNA evaluated fecal FIVE followed by HCoV HCoV-229E hCoV-229E. human coronavirus Infection Isolation less methodology Mild molecular Neutral parameter PCR PMMoV prevalence of COVID-19 provide public health qPCR quantification reported RNA extraction RNA isolation kit RT-qPCR Salmon SARS-CoV-2 SARS-CoV-2 detection sensitivity significantly significantly increased Surveillance threshold Ultrafiltration Variation Viral Viral RNA virus viruses was used wastewater [DOI] 10.1016/j.scitotenv.2021.151434 PMC 바로가기 [Article Type] Article
A Novel Method to Reduce ELISA Serial Dilution Assay Workload Applied to SARS-CoV-2 and Seasonal HCoVsArticle Published on 2022-03-092023-06-14 Journal: Viruses [Category] MERS, SARS, [키워드] Bayesian analysis ELISA endpoint assay HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 hierarchical modelling inflection titer SARS-CoV-2 [DOI] 10.3390/v14030562 PMC 바로가기 [Article Type] Article
Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.Article Published on 2022-03-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제, [키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics [DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article
Effective presence of antibodies against common human coronaviruses in immunoglobulin medicinal products면역글로불린 의약품에서 일반적인 인간 코로나바이러스에 대한 항체의 효과적인 존재Article Published on 2022-03-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] 229E acute respiratory syndrome administration antibodies antibody cells Concentration conducted contribute Coronavirus-2 cross-reactivity Czech Republic donors ELISA ELISAs enzyme-linked immunosorbent assay explain expressed Germany HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 Human human coronavirus Immunoglobulin immunoglobulins intramuscular intravenous knowledge Neutralization assay NL63 OC43 patients plasma presence of antibody product severity Spain tested the antibody USA [DOI] 10.1016/j.ijid.2021.12.329 PMC 바로가기 [Article Type] Article
Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic VariantsSARS-CoV-2에 대한 고전 및 차세대 백신 플랫폼: 생명공학 전략 및 게놈 변이Review Published on 2022-02-182022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] aAPC Ad5-nCoV adaptive Amino acid amino acids animals antibody applied B.1.1.7 B1.351 BBIBP-CorV bind Biotechnology BNT Cell classical clinical trial consequence CoronaVac coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs D614G Deletion demonstrated dendritic cell dendritic cells domain escape Evolution genomic variant genomic variants HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high affinity HKU1 hosts Human humans inactivated incorporation inhibit INO-4800 JNJ-78436735 lentiviral Lentiviral vector LV-SMENP-DC MERS-CoV molecular mRNA mRNA-1273 mutated nCoV New new SARS-CoV-2 new strain NL63 NVX-CoV2373 vaccine P.1 pathogen Pathogens platform Protein RBD receptor ACE2 Receptor-binding domain recombinant vaccine recombinant vaccines replacement residue responsible RNA vaccines S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants strain Strains Strategy subunits technological platforms tested the S protein Transmissibility trials Vaccine vaccine production Vaccines variant variants variety Viral virus-like particles β-coronavirus β-CoV β-CoVs [DOI] 10.3390/ijerph19042392 PMC 바로가기 [Article Type] Review
Full Genome of batCoV/MinFul/2018/SriLanka, a Novel Alpha-Coronavirus Detected in Miniopterus fuliginosus , Sri LankaArticle Published on 2022-02-072022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Miniopterus fuliginosus Amino acid bat bat alphacoronavirus bats cave cave-dwelling collected conserved coronavirus CoV full genome Genetic genome sequence HCoV-229E HCoV-NL63 Host humans identity Infection information Mild Miniopterus novel nucleotide one health populations potential transmission Prevalence rectal swab Research resulting risk selected severe respiratory symptoms specificity Sri Lanka strain structural protein sympatric colony Transmission Variation virus β-CoV β-CoVs [DOI] 10.3390/v14020337 PMC 바로가기 [Article Type] Article
Evolution of Viral Pathogens Follows a Linear OrderResearch Article Published on 2022-02-022022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, 신종인플루엔자, [키워드] acute respiratory syndrome addition Amino acid Analysis contribute coronavirus coronavirus disease COVID-19 dengue virus determine distribution Evidence Evolution H1N1 H3N2 HCoV-229E HCoV-NL63 HCoV-OC43 Infectious disease influenza A linear linear order MERS MERS-CoV Microbiology Middle East outbreak Outbreaks predict random reveal SARS-CoV SARS-CoV-2 serotype shown subsequent syndrome triggering Vaccine variants of concern viral family viral genome viral mutation viral pathogen virus Zaire Zika [DOI] 10.1128/spectrum.01655-21 PMC 바로가기 [Article Type] Research Article
Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In VitroArticle Published on 2022-01-212022-10-30 Journal: Molecules [Category] COVID-19, [키워드] anti-coronavirus activity antimalarial antiviral drug caused Clinical studies coronavirus Coronavirus infection COVID-19 demonstrated drug effective Emergency use function HCoV-229E HCoV-OC43 in vitro malaria Naphthoquine pandemic performed potent problems public health Replication Repurposed drug repurposing SARS-CoV-2 SARS-CoV-2 replication Spread suggested therapeutic effect treat Vaccine virus entry [DOI] 10.3390/molecules27030712 PMC 바로가기 [Article Type] Article
The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23Article Published on 2022-01-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activity Amphibian antimicrobial peptide antimicrobial peptides antiviral activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral molecule antiviral therapy contrary coronavirus DNA DNA and RNA drugs early stage effective evaluated exhibited greater HCoV-229E HSV-1 identify inactive indicated Infection inhibitory activity investigated peptide peptides performed Potential reported RNA SARS-CoV-2 secretion strain therapeutic effect therapeutic options variety viral infections virus viruses [DOI] 10.3390/ijms23020883 PMC 바로가기 [Article Type] Article