Up-regulated serum levels of soluble CD25 and soluble CD163 in pediatric patients with SARS-CoV-2SARS-CoV-2 소아 환자에서 가용성 CD25 및 가용성 CD163의 상향 조절된 혈청 수준Original Article Published on 2022-03-022022-09-11 Journal: European journal of pediatrics [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] age antagonist antagonists CD163 children Control COVID-19 cytokine Cytokine storm diagnostic biomarker Diagnostic biomarkers disease severity ELISA healthy control help hemophagocytic lymphohistiocytosis HLH host response Inflammatory initial Level marker MIS-C monitoring outcome Patient patients with COVID-19 patients with SARS-CoV-2 Pediatric patient presenting pro-inflammatory receptor SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients sCD163 sCD25 serum Serum level severity significant decrease significantly higher soluble CD25 syndrome the disease the healthy therapeutic Treatment up-regulated were measured [DOI] 10.1007/s00431-022-04398-8 PMC 바로가기 [Article Type] Original Article
Neonatal COVID and Familial Hemophagocytic Lymphohistiocytosis신생아 코로나 및 가족성 혈구탐식성 림프조직구증Article Published on 2022-03-012022-09-11 Journal: Pediatric emergency care [Category] SARS, 변종, [키워드] COVID Familial hemophagocytic lymphohistiocytosis [DOI] 10.1097/PEC.0000000000002643 PMC 바로가기 [Article Type] Article
Acute hepatitis A infection‐associated hemophagocytic lymphohistiocytosis in adult presenting as impending acute liver failure: A case report and literature reviewCase Report Published on 2022-02-072023-08-30 Journal: Clinical Case Reports [Category] E형 간염, [키워드] Case report hemophagocytic lymphohistiocytosis hemophagocytic syndrome hepatitis A hepatitis A virus infection‐associated hemophagocytic syndrome [DOI] 10.1002/ccr3.5334 PMC 바로가기 [Article Type] Case Report
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?COVID-19 관련 사이토카인 폭풍은 비-COVID-19 이차성 혈구포식성 림프조직구증과 구별되는가?Review Published on 2022-02-012022-09-12 Journal: Experimental Biology and Medicine [Category] MERS, 진단, [키워드] acute respiratory distress adaptive ARDS characterized circulating cytokine Clinical diagnosis COVID-19 criteria cytokine Cytokine storm Cytokines Diagnosis elevated hemophagocytic lymphohistiocytosis HLH Hyperactivation immune cells immunobiology immunology/microbiology/virology Inflammation Inflammatory Non-COVID-19 patients Pneumonia syndrome Treatment [DOI] 10.1177/15353702211068840 PMC 바로가기 [Article Type] Review
Probable hemophagocytic lymphohistiocytosis by extensively drug-resistant Salmonella Typhiarticle Published on 2022-01-312024-09-01 Journal: Pediatrics International [Category] 살모넬라증, [키워드] hemophagocytic lymphohistiocytosis hemophagocytic syndrome meropenem Salmonella enterica serovar Typhi typhoid fever [Article Type] article
A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm SyndromeArticle Published on 2022-01-202022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] accompanied Activation approach Blood caused CD107a CD8 T cell Cell clinical feature Coronavirus disease 2019 COVID-19 cytokine levels Cytokine storm Cytokine storm syndrome cytolysis cytotoxicity death degranulation disease dominant-negative elevated erythroleukemia etiologies Ex vivo expression feature gene mutations genetic defect genetic evaluation genetic mutations genetics hemophagocytic lymphohistiocytosis heterozygous HLH homozygous hyperinflammation hypomorphic Hypothesis immune response immune system implicated implication in vitro infancy Laboratory lentiviral macrophage activation syndrome Missense mutation monoallelic mutant Mutation natural killer natural killer cell NK cell NK cell function resulting secondary Severe case severe COVID-19 sHLH significantly stimulated storm STXBP2 syndrome system failure target cell transduced triggered viral infection were measured while wild-type [DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article
Cytokine Storm in COVID-19: Immunopathogenesis and TherapyCOVID-19의 사이토카인 폭풍: 면역 병인 및 치료Review Published on 2022-01-182022-09-12 Journal: Medicina [Category] SARS, 진단, [키워드] administration affected Allogeneic allogeneic hematopoietic stem cell transplantation Anakinra antibody autoinflammatory disease CAR Care clinically Coagulopathy conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill critically ill patients cytokine cytokine inhibitors Cytokine storm Cytokines death deregulated disease disease severity effective effort excessive production of cytokines glucocorticoid Glucocorticoids GM-CSF Graft Graft-versus-host disease Hematopoietic stem cell hemophagocytic lymphohistiocytosis Hope hyperinflammatory state IFN-γ IL-1 IL-10 IL-2 IL-6 immune cells immune system IP-10 jak inhibitors leading MCP-1 Methylene blue mitigate multi-organ failure Novel coronavirus novel coronavirus disease overcome pandemic Pathogenesis Patient Plasmapheresis pro-inflammatory cytokines reducing mortality secondary hemophagocytic lymphohistiocytosis secondary to Sepsis severe cases stem cell Stem cell transplantation storm syndrome T-cell tested the cytokine storm the disease therapeutic strategy therapy TNF-α to define Tocilizumab [DOI] 10.3390/medicina58020144 PMC 바로가기 [Article Type] Review
Hemophagocytosis, hyper-inflammatory responses, and multiple organ damages in COVID-19-associated hyperferritinemiaClinical Trial Published on 2021-12-042022-10-04 Journal: Annals of Hematology [Category] MERS, SARS, 임상, [키워드] 95% CI age Analysis ARDS AUROC Characteristics chronic pulmonary disease COVID-19 COVID-19 patients cut-off value D-dimer death described Fever hemophagocytic lymphohistiocytosis hsCRP hyper-inflammation Hyper-inflammatory responses Hyperferritinemia IL-6 In-hospital death in-hospital mortality independent predictor indicated mechanical ventilator median much higher Multiple organ damage organ dysfunction Patient patients with AKI Prevalence Prognosis progressed proportion Retrospective study supplementary material Support [DOI] 10.1007/s00277-021-04735-1 PMC 바로가기 [Article Type] Clinical Trial
Neutropenic Fever in a Patient With SARS-CoV-2-Induced Hemophagocytic Lymphohistiocytosis (HLH)Infectious Disease Published on 2021-12-022022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus Case report COVID-19 COVID-19 infection cytokine release storm develop etiology Fever follicular hemophagocytic lymphohistiocytosis Hemophagocytic lymphohistiocytosis (HLH) HLH Hospital admission immune dysregulation immunomodulatory drugs Neutropenic neutropenic fever non hodgkin's lymphoma Non-Hodgkin Lymphoma overlap Patient produced SARS-CoV-2 syndrome systemic inflammatory Treatment [DOI] 10.7759/cureus.20101 PMC 바로가기 [Article Type] Infectious Disease
Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study중증 SARS-CoV-2 감염에서 혈구포식세포 조직구증: 골수 연구Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] MERS, SARS, 바이오마커, [키워드] albumin analyzed BME Bone marrow bone marrow examination CD25 Cell clinical and laboratory features Corticosteroid corticosteroid therapy COVID-19 infection criteria CRP cytopenia cytopenias D-dimer Diagnostic Criteria disorder eight elevated Fever FIVE four of eight hemophagocytic lymphohistiocytosis Hemophagocytosis High-dose histiocytosis histiocytosis. HLH Hyperferritinemia hyperfibrinogenemia Hyperinflammatory hypertriglyceridemia Hypofibrinogenemia immune response initiated laboratory feature LDH Leukocytosis lymph nodes lymphocytopenia lymphocytosis marrow examination natural killer neutrophilia organomegaly overlap Patient patients plasma raised required SARS-CoV-2 serum albumin serum CRP Serum ferritin Severe COVID-19 Infection severe SARS-CoV-2 soluble CD25 spleen syndrome therapy transaminase transaminases Triglyceride triglycerides Viral viral infections [DOI] 10.1111/ijlh.13619 PMC 바로가기 [Article Type] Comparative Study