Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련Article Published on 2022-06-032022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication [DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article
Protein engineering responses to the COVID-19 pandemic코로나19 팬데믹에 대한 단백질 공학 대응Review Published on 2022-06-012022-09-11 Journal: Current opinion in structural biology [Category] COVID19(2023년), SARS, 변종, [키워드] Antigen breadth candidate COVID-19 COVID-19 pandemic COVID-19 vaccine develop display elicited glycoprotein High-resolution human population Humoral immunity nanoparticle neutralization potency other coronavirus other coronaviruses PROTECT researcher response robust SARS-CoV-2 variant SARS-CoV-2 variants Structure structure-based design Substitution vaccine candidate [DOI] 10.1016/j.sbi.2022.102385 PMC 바로가기 [Article Type] Review
SARS-CoV-2 transmission, persistence of immunity, and estimates of Omicron’s impact in South African population cohortsResearch Article Published on 2022-05-312022-10-04 Journal: Science Translational Medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome African analyzed building Characteristics Cohort cohorts complex condition coronavirus cross-protection cross-protective immunity cumulative description Epidemic epidemic wave Epidemics epidemiological estimate facilitate favor fraction help High-resolution Immunity Infection infection rate mathematical omicron pandemic persistence population immunity SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 variant serology South South Africa trajectory Transmission understanding vaccination variant variants [DOI] 10.1126/scitranslmed.abo7081 PMC 바로가기 [Article Type] Research Article
Allergic shiners in a patient with cough-variant asthma: a case report기침-변형 천식 환자의 알레르기 샤이너: 증례 보고Case Reports Published on 2022-05-282022-09-11 Journal: Journal of Medical Case Reports [Category] 변종, [키워드] Adults Affect allergic Allergic shiners Asthma baseline Case report cause Challenge test characterized Chest chest X-ray chronic Chronic cough classic Computed tomography coronavirus disease Coronavirus disease 2019 cough Cough-variant asthma. coughing Diagnosis disappearance example excessive use extreme eyelid General population hacking cough heliotrope rash High-resolution Hyperinflation initiated Laboratory test limits Methacholine mimicking neuronal pandemic parameters pathway Patient phenotype Physical examination positive presenting Pulmonary function test Rash resulting Reversibility sensitivity severity Symptom Treatment tree urge [DOI] 10.1186/s13256-022-03423-6 PMC 바로가기 [Article Type] Case Reports
Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousnessArticle Published on 2022-05-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute infection B.1.1.7 circulating clearance clearance rate contribute Daily explained Genome heterogeneity High-resolution Human in viral individual individual-level heterogeneity Infection Infectious virus nasal swabs peaked reveal Saliva SARS-COV-2 infection SARS-CoV-2 replication Significant tissue Transmissibility variant Variation Viral load Viral RNA shedding virus [DOI] 10.1038/s41564-022-01105-z PMC 바로가기
Contour-enhanced attention CNN for CT-based COVID-19 segmentationResearch article Published on 2022-05-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Attention Automatic chest CT scan clinical care CNN Context coronavirus COVID-19 datasets Decoder deep learning effective evaluated feature fusion healthcare High-resolution information Morphological pandemic recall Research Segmentation similarity tissue [DOI] 10.1016/j.patcog.2022.108538 [Article Type] Research article
High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeMHC II 펩티드 제시 능력의 고해상도 프로파일링으로 SARS-CoV-2 CD4 T 세포 표적 및 면역 탈출 메커니즘 밝혀Article Published on 2022-04-292022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alleles alteration arising CD4 comprehensive analysis effective response epitope High-resolution HLA class II HLA class II alleles Immune escape immune evasion in silico in viral limitation mammalian mass spectroscopy mechanism MHC MHC allele MHC alleles MHC class MHC class II MHC II MHC II alleles Mutation peptide peptides physiological function physiological functions platform Precision provide reduced reveal SARS-CoV-2 SARS-CoV-2 peptide sensitivity silico predictions strain T cell T cells target therapeutic use threat Threats throughput understanding viral strains [DOI] 10.1126/sciadv.abl5394 PMC 바로가기 [Article Type] Article
Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events고해상도 접촉 네트워크를 사용하여 대규모 수일 이벤트에서 SARS-CoV-2 전송 및 제어 평가Article Published on 2022-04-122022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] activities close contact collected Contact country Coverage Crew Delta delta variant evaluate event High-resolution influence Intervention IQR Mask mask mandate Mask mandates median Outbreaks per day rapid antigen test Rapid antigen tests reduce required risk SARS-CoV-2 transmission SARS-CoV-2 variant social contact the vaccine Transmission unique vaccination [DOI] 10.1038/s41467-022-29522-y PMC 바로가기 [Article Type] Article
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function임상적으로 사용되는 미세소관 표적 약물이 바이러스 감염 및 전달 기능에 미치는 영향Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] analyzed Angiogenesis antiviral activity antivirals biochemical cellular clinically complex compounds correlation crystal structure cytoskeleton DNA and RNA drug drugs Effect function High-resolution higher impact Infection information living cells Mebendazole mebendazole-tubulin complex crystal structure mechanism microtubule microtubule targeting drugs. molecular mechanism movement peptide provided RNA viruses SARS-CoV-2 Structure targeting tested these compound these compounds Toxicity Transport viral infection viral infections viruses [DOI] 10.3390/ijms23073448 PMC 바로가기 [Article Type] Article
Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient by LC-MS/MS-based analysisLC-MS/MS 기반 분석을 통한 COVID-19 환자의 호흡기 표본(VTM)의 글로벌 프로테옴, 바이롬 및 메타프로테옴 프로파일링을 위한 프로토콜Article Published on 2022-03-182022-09-11 Journal: STAR protocols [Category] SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis Bacterial Bioinformatics analysis Complete COVID-19 patient COVID-19 patients digestion downstream H1N1 H1N1 patients Health Sciences High-resolution Host include Major mass mass spectrometry Patient peptides Protein proteome proteomics protocol provided quantification specimen virus inactivation VTM with COVID-19 [DOI] 10.1016/j.xpro.2021.101045 PMC 바로가기 [Article Type] Article