Predicting Mutational Effects on Receptor Binding of the Spike Protein of SARS-CoV-2 VariantsSARS-CoV-2 변이체의 스파이크 단백질 수용체 결합에 대한 돌연변이 효과 예측Article Published on 2021-10-272022-09-11 Journal: Journal of the American Chemical Society [Category] SARS, 변종, 유전자 메커니즘, [키워드] Amino acid amino acids antibody antibody m396 approach binding binding affinity calculate caused change correlated Delta delta variant Delta variants domain Effect Effectiveness experiments faster free energy functional higher infectivity in silico investigated m396 mechanism mutant mutants mutate Mutation mutations offer Other pandemic predict predicted problem provided receptor reduction SARS-CoV-2 South Africa speed Spike protein Surveillance the binding affinity the Spike variant variants virus was done was used were assessed [DOI] 10.1021/jacs.1c07965 PMC 바로가기 [Article Type] Article
Unrecognized introduction of SARS-CoV-2 variants of concern to Central Africa: Import and local transmission of B.1.1.7 in Gabon in the very early stage of the variant spread to the African continent중앙 아프리카에 대한 SARS-CoV-2 변종의 인식되지 않은 도입: 변종이 아프리카 대륙으로 확산되는 초기 단계에서 가봉에서 B.1.1.7의 수입 및 지역 전파Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Africa African Analysis B.1.1.7 B.1.1.7 variant B.1.1.7 variants coronavirus early stage Gabon genomic higher infectivity Hospitalized import increase in Infection infections initial introduced Local Patient Phylogenetic analysis Phylogeny regions risk SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spread spread to The B.1.1.7 Transmission variant variants variants of concern [DOI] 10.1002/jmv.27164 PMC 바로가기 [Article Type] Article
Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions인간 신장 회전 타원체 및 단층은 SARS-CoV-2 신장 상호 작용에 대한 통찰력을 제공합니다Article Published on 2021-09-012022-09-11 Journal: Journal of the American Society of Nephrology : JA [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey AKI baseline level cause Cell cell death cellular proliferation clone Col1a1 Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cultures cytopathic cytopathic damage Cytopathic effect dedifferentiation demonstrated disease Elevation epithelial cell epithelial cells Ex vivo exhibited fibrosis green monkey help higher infectivity Human human kidney human tubular kidney cells identity infect Injury insight Interaction interferon interferon pathway Intervention kidney Kidney disease kidney infection kidney spheroids kidney stem cells less LRP2 mechanisms monolayer monolayers morbidity outcome patients with COVID-19 presenting pulmonary involvement reduction in renal renal progenitors renal tubular renal tubular epithelial cells. Replication replication of SARS-CoV-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus SNAI2 Spheroid STAT6 Support Symptom the disease tubular cell Vero E6 viral entry viral infection virus with COVID-19 [DOI] 10.1681/ASN.2020111546 PMC 바로가기 [Article Type] Article
Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis고해상도 용융 분석을 이용한 SARS-CoV-2 변이체 유전자형 플랫폼 개발Article Published on 2021-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 변종, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis characteristic clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determinant development FIVE genome sequence genotyping Genotyping method GISAID high resolution High resolution melting High-resolution higher infectivity Human human saliva identify Infection investigated matrix effect mutant viruses mutated Mutation Novel coronavirus platform Real-time PCR reduce reported reverse transcription RNA fragment RNA virus Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support synthetic DNA fragment synthetic DNA fragments undergo virus mutation wild-type [DOI] 10.1016/j.jiac.2021.06.007 PMC 바로가기 [Article Type] Article
Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 PatientsPhysiology Published on 2021-08-232022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] abnormality ACE2 Acute kidney injury acute respiratory syndrome AKI angiotensin-converting enzyme 2 Bioavailability biological activity clinical manifestation Coagulation complication of COVID-19 contributing to coronavirus Coronavirus disease 2019 COVID-19 death depleting disease downstream Effect enzyme etiological agent expressed expression high affinity higher infectivity highlighting Hospital admission Inflammatory Injury Interaction Kallikrein-kinin system kidney Kidney injury kidneys less many cases minor symptom mortality rate Multi-organ damage Observed organ pandemic Pathogenesis pathogenesis of COVID-19 physiological systems promote RAS receive receptor reduce Regulation renal renin-angiotensin system reported required SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Spread Symptom Symptoms therapy Transmissibility virus Wuhan, China [DOI] 10.3389/fphys.2021.700220 PMC 바로가기 [Article Type] Physiology
Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants작은 구조 단백질 E와 M은 SARS-CoV-2 슈도바이러스를 더 전염성이 있게 만들고 천연 바이러스 변이체의 표현형을 드러냅니다Article Published on 2021-08-232022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] angiotensin antigenic biological function Cell convalescent sera dissemination dominant E and M proteins evaluate examined expressing hACE2 higher infectivity human Angiotensin-converting enzyme mechanism membrane molecular natural Neutralizing packaged plasma priming Protein provide pseudotype virus pseudovirus pseudoviruses receptor reported S protein SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S SARS-CoV-2 variants SEM spike structural protein the S protein the SARS-CoV-2 variant variants Viral viral infectivity Viral RNA virion virion infectivity virus viruses [DOI] 10.3390/ijms22169087 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current EvidenceReview Published on 2021-06-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] article association asymptomatic patients Cohort conducted country COVID-19 COVID-19 pandemic current D614G variant epidemiological evaluate Evidence Fatality rate Google Scholar higher infectivity in vitro in vivo Infection Infectivity less mutants Mutation ORF1ab Patient patients reported S protein SARS-CoV-2 SARS-CoV-2 variant Severe infection severity severity of COVID-19 significantly significantly more Spread the disease transmissibility of SARS-CoV-2 variant variants variants of concern viral mutation Viral mutations virulence Web of Science wild-type virus [DOI] 10.3390/jcm10122635 PMC 바로가기 [Article Type] Review
Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung CancerMolecular Biosciences Published on 2021-06-112022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 binding binding affinity blocked caused Cell coronavirus disease COVID-19 derivative derivatives effective expression G614 mutant G614 variant global public health heparan sulfate higher infectivity host cell host cell surface host cells Increased infect Infection Interaction lung cancer lung cancer patient mechanism motifs mutant pseudovirus required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein sulfate Support surface receptor the SARS-CoV-2 Treatment upregulated virus [DOI] 10.3389/fmolb.2021.649575 PMC 바로가기 [Article Type] Molecular Biosciences
Interpretation of laboratory tests for prevention of the SARS-CoV-2 transmissionSARS-CoV-2 전파 방지를 위한 실험실 검사 해석Article Published on 2021-06-012022-09-11 Journal: Journal of anesthesia [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol applied Care cause Chain Reaction Clinical practice Cluster coronavirus coronavirus disease Coronavirus disease 2019 detect discharge disease enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays Epidemiology higher infectivity hospital hospitals human body Infection Laboratory test Laboratory tests lung nose polymerase chain polymerase chain reaction positive Prevent Probability provided reduce reproductive Research reverse transcription reverse transcription polymerase chain reaction SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 stability sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specificity Spread Statistics the patient the SARS-CoV-2 Transmission transmission of SARS-CoV-2 understanding uninfected Universal [DOI] 10.1007/s00540-020-02872-x PMC 바로가기 [Article Type] Article
SARS-CoV-2: The Second Wave in EuropeSARS-CoV-2: 유럽의 두 번째 물결Viewpoint Published on 2021-05-182022-09-10 Journal: Journal of Medical Internet Research [Category] SARS, 변종, [키워드] accompanied Analysis COVID-19 COVID-19 epidemic COVID-19 outbreak death deaths Europe European European country First wave Forecasting higher infectivity increasingly infected case infected cases lead less lifted lockdown lockdown in Europe mathematical modelling of epidemics measure much higher mutated Mutation mutations number of deaths pandemic predicted raised remained reported responsible resulting SARS CoV-2 SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 virus second second wave study group the SARS-CoV-2 virus virulence virulent Wave [DOI] 10.2196/22431 PMC 바로가기 [Article Type] Viewpoint