histone – Page 3 – Communicable Diseases Research

Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma

Research Article

Published on 2021-03-082023-06-03
Journal: Clinical and Translational Medicine [Category] B형 간염, Fulltext,

Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19

Article

Published on 2021-02-092022-10-04
Journal: Scientific Reports [Category] MERS, 신약개발, 치료기술, 치료법,

Biologic Drugs for Rheumatoid Arthritis in the Context of Biosimilars, Genetics, Epigenetics and COVID-19 Treatment

바이오시밀러, 유전학, 후성유전학 및 COVID-19 치료의 맥락에서 류마티스 관절염에 대한 생물학적 약물

Review

Published on 2021-02-042022-08-31
Journal: Cells [Category] 신약개발,

[키워드] achievement addition Affect Arthritis B cell B cells bDMARDs biologic agent biologic agents Biological Biologicals biologics biosimilars Care Context COVID-19 COVID-19 outbreak diagnosing disability DNA methylation drug drugs drugs targeting effective effective therapy Efficacy epigenetics facilitate Factor genetics GM-CSF histone IL-1 IL-6 IMPROVE inhibit life limitation miRNA expression Modification patients Premature Quality of life respond Rheumatoid rheumatoid arthritis rheumatology Safe shown Symptom T cell T cells therapeutic intervention therapy TNF Treatment Usage widespread
[DOI] 10.3390/cells10020323 PMC 바로가기 [Article Type] Review

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다

Article

Published on 2021-02-012022-09-11
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19
[DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article

Molecular Mechanisms of Vascular Damage During Lung Injury

폐 손상 중 혈관 손상의 분자 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: Advances in experimental medicine and biology [Category] 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ADRS alveolar epithelium ARDS association behavioral risk factors change contribute COVID-19 Cytokines damage disease disease risk Disruption DNA DNA methylation endothelial activation Enzyme inhibitor Enzyme inhibitors Epigenetic epigenetics epithelial Epithelial barrier evaluate experimental model experimental models explained Factor focus Genetic genetic factors Genetic polymorphism genetic polymorphisms Genetic predisposition high mortality rate histone Histone acetylation, DNA methylation Hospitalization humans increased vascular permeability Inflammation Inflammatory response Injury intensive care lung endothelial Lung injury mechanism Modification molecular mechanism molecular mechanisms Mortality occur offer Pathogenesis phenotypic potential therapeutic target Prevent pro-inflammatory cytokines promote Research respiratory distress Respiratory distress syndrome Risk factors susceptibility syndrome systemic and local treat variety Vascular damage Vascular endothelium vascular permeability
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review

Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection

Cell and Developmental Biology

Published on 2020-12-182022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing
[DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology

Opposing functions of Fng1 and the Rpd3 HDAC complex in H4 acetylation in Fusarium graminearum

Fusarium graminearum의 H4 아세틸화에서 Fng1 및 Rpd3 HDAC 복합체의 반대 기능

Research Article

Published on 2020-11-022022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a minor Affect ascomycetes barley Blight blocked characterized Chromatin structure chromosomal region complex complexes component components conidiation Critical Deletion deletion mutant disease elevated ENCODE euchromatin expression level faster filamentous fungi frameshift function functional fungal fungi Fusarium Genes Genetic variations Glutamine growth growth defects growth rate had no HDAC head histone homolog hyphal hypothetical hypothetical protein Infection ING1 inhibitor interact invasive involved minor MOST mutant Mutation nonsense mutation occurred ortholog orthologs pathogenicity Protein reduced reduction in regulate Regulation reported RNA-seq analysis sexual development sexual reproduction significantly strain suppress suppressor Suppressor mutations transcriptional transcriptional regulation unique vegetative growth wheat while yeast
[DOI] 10.1371/journal.pgen.1009185 PMC 바로가기 [Article Type] Research Article

NETosis: Molecular Mechanisms, Role in Physiology and Pathology

NETosis: 분자 기전, 생리학 및 병리학에서의 역할

Review

Published on 2020-10-012022-09-12
Journal: Biochemistry. Biokhimiia [Category] MERS, SARS, 진단,

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

C형 간염 바이러스는 직접 작용하는 항바이러스제에 의한 감염 치료 후 후성 유전적 특징을 남깁니다.

Research Article

Published on 2019-06-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acting Alter alteration Anti-HCV Antiviral approach Biomarker Cell cells change changes in characterized Chemotherapy ChIP-seq chromatin chromatin immunoprecipitation chronic hepatitis develop direct-acting antiviral disease drug Effect EGFR EGFR Inhibitor enzyme Epidemiological study Epigenetic Erlotinib Europe expected explain expression followed by gene signature Genome HCC HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma histone Hit and run host gene expression identify in vitro induce infected case infected patient Infection inhibit inhibitor interferon life cycle liver Liver Biopsy marker mechanism Modification molecular mechanism Mortality Multiple Multiple epidemiological studies Next-generation sequencing observation offer oncogenic outcome Pathogenesis pathogenic Pathways Patient persist poor prognosis post-translational modification predominant Prevalence proceed replaced repressed risk risk factor RNA signaling pathway specific inhibitor specific inhibitors sustained the cells therapeutic target therapy Treatment Tumor unmet need Viral protein Viral proteins virological response virus while
[DOI] 10.1371/journal.pgen.1008181 PMC 바로가기 [Article Type] Research Article

Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine

스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.

Research Article

Published on 2018-11-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety
[DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article