Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trialMedicine Published on 2024-07-162024-09-05 Journal: eLife [Category] update2024, [키워드] COVID-19 DNA DNase Dornase alfa histone Incomplete Inflammation NETs Valuable viruses [DOI] 10.7554/eLife.87030 PMC 바로가기 [Article Type] Medicine
Genome-wide binding sites of Plasmodium falciparum mini chromosome maintenance protein MCM6 show new insights into parasite DNA replicationarticle Published on 2023-10-312024-09-01 Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research [Category] 말라리아, [키워드] ChIP seq H3K9Ac H4K8Ac histone PfARS PfMCM6 PfORC1 Plasmodium Replication [Article Type] article
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnessesarticle Published on 2023-02-282024-09-05 Journal: Critical Care [Category] update2024, [키워드] Critical illness extracorporeal blood purification High mobility group box-1 histone Inflammation Sepsis [DOI] 10.1186/s13054-023-04382-0 PMC 바로가기 [Article Type] article
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumoniaArticle Published on 2022-12-132023-06-20 Journal: Immunity [Category] Fulltext, MERS, [키워드] Actin COVID-19 Degradation DNA DNase I histone Inflammation NETs proteomics Sepsis [DOI] 10.1016/j.immuni.2022.11.007 PMC 바로가기
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approachesSARS CoV-2 감염의 후성유전학적 기전과 잠재적인 치료적 접근의 이해Review Published on 2022-09-012022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral immune response association build caused Community coronavirus COVID-19 disease severity DNA DNA methylation drug effective eliminating Epigenetic epigenetic regulator epigenetics Escalation Health highlight histone Histone modification host cell host cells immune immune responses Immunity Infection initial Interaction mechanism microRNA Modification Mortality pandemic Pathogenesis pathogenesis of SARS-CoV-2 reduced risk SARS CoV-2 SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity subsequent the disease Therapeutic approach therapeutic intervention Therapies understanding variants of SARS-CoV-2 viral infection Virology [DOI] 10.1016/j.virusres.2022.198853 PMC 바로가기 [Article Type] Review
Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsisArticle Published on 2022-08-302022-11-15 Journal: Critical Care [Category] 진단, [키워드] alteration assessment Biomarkers blood cell breadth Cell change Characteristics circulating classical contribute COVID-19 COVID-19 sepsis Critical care critical condition cytoplasmic death demonstrated distribution DNA drug extracellular trap granularity healthy healthy control heparin higher risk highlighting histone Histones in vitro in vivo Inflammatory involved key factor laboratory feature measurement Modification modulating monocyte Monocyte distribution width neutralization nuclear Pathologies Pathways Patient patients with COVID-19 procoagulant activity Prominent Protein Regulation released Sepsis sepsis patients severity significant increase subject thrombosis treated Treatment vacuolization Volume Whole blood whole blood sample [DOI] 10.1186/s13054-022-04138-2 PMC 바로가기
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] adaptive attenuate Bacteria CD169 cytokine degrade deplete detrimental downstream effector fungi G-CSF histone hyperinflammation hyphae immature immune dysfunction Immunity induce Infection infiltration Macrophage macrophages mechanism mechanism of action microbial Mortality myeloperoxidase neutralize neutrophil oxidative burst pathogen pathology Patient patient mortality phagocytic plasma promote receptor receptors Sepsis T cell Trigger zone [DOI] 10.1038/s41467-022-32320-1 [Article Type] Research
Distinct Histone Post-translational Modifications during Plasmodium falciparum Gametocyte DevelopmentArticle Published on 2022-08-052024-08-29 Journal: Journal of Proteome Research [Category] 말라리아, [키워드] Gametocytes histone Plasmodium falciparum post-translational modification
Platelets in the NETworks interweaving inflammation and thrombosis염증과 혈전을 뒤섞는 NETworks의 혈소판Review Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus [DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review
NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study패혈성 쇼크 및 심각한 COVID-19 환자의 NETosis 및 뉴클레오솜 바이오마커: 관찰 연구Observational Study Published on 2022-07-272022-09-11 Journal: Biomolecules [Category] MERS, 바이오마커, 임상, [키워드] alternative Biomarker Biomarkers cell death conditions Control control subject COVID-19 Critical critical COVID-19 patient critical COVID-19 patients Defense discrimination disease severity evaluate extracellular trap histone ICU Infection Intact intensive care intensive care unit marker matched control mechanism microorganisms MPO myeloperoxidase NET NETosis NETs NETs’ formation neutrophil neutrophil activation neutrophil count Neutrophil elastase Neutrophil extracellular traps Neutrophils normalization Nucleosome nucleosomes P -value p -values patient cohort patients phagocytosis recruited Result SARS-CoV-2 septic Septic shock Significant significant differences Spread subject were measured [DOI] 10.3390/biom12081038 PMC 바로가기 [Article Type] Observational Study