host receptor – Page 3 – Communicable Diseases Research

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

SARS-CoV-2 수용체 결합 도메인 인터페이스에서의 상위성과 백신 탈출에 대한 지루한 의미

Article

Published on 2022-04-262022-09-11
Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

SARS-CoV-2 오미크론 스파이크 돌연변이에 의한 구조적 및 기능적 영향

Article

Published on 2022-04-262022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter antigenic antigenic structure cellular tropism coronavirus country CP: Molecular biology cryo cryo-EM dominant evade full-length functional host immunity host receptor membrane fusion Molecular biology mutations N-terminal domain Neutralizing antibodies not seen omicron Omicron variant other variants prevalent Protein Receptor-binding domain S protein SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus spike mutation Spike protein Structure the receptor-binding domain the S protein variant variants
[DOI] 10.1016/j.celrep.2022.110729 PMC 바로가기 [Article Type] Article

Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron Mutations

SARS-CoV-2 스파이크 변이체 복합체와 숙주 수용체의 결합 및 알로스테릭 상호작용에 대한 컴퓨터 시뮬레이션 및 네트워크 기반 프로파일링: 델타 및 오미크론 돌연변이의 기계적 효과 분석

Article

Published on 2022-04-152022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 complexes ACE2 host receptor allosteric communications analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding energetics binding energy binding interaction Community Community network complexes computer constellation contribute Critical Delta Effect energetics Epitopes escape mutants examined functional generate Host host receptor hotspot identify immune evasion integrity Interaction interactions Local MD simulation modulate molecular molecular dynamics Mutation mutational scanning N501Y network analysis omicron Omicron variants plasticity Profiling RBD-ACE2 residue responsible S protein S-RBD SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity signal transmission. Simulation spike Spike protein the RBD the SARS-CoV-2 Transmissibility Transmission variant variants virus
[DOI] 10.3390/ijms23084376 PMC 바로가기 [Article Type] Article

Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence

국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다

Article

Published on 2022-04-012022-09-11
Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus
[DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article

Virtual Screening of Natural Chemical Databases to Search for Potential ACE2 Inhibitors

Article

Published on 2022-03-072022-10-30
Journal: Molecules [Category] COVID-19,

[키워드] ACE2 acute lung injury acute respiratory syndrome ADME Angiotensin-converting enzyme binding affinity binding mode calculated Chemical Compound conditions coronavirus coronavirus disease COVID-19 database diabetes disease Diseases Drug discovery drug target drug-likeness evaluate function Glide Health host cell host receptor inhibition activity inhibitor inhibitors Interaction Ligand modulation molecular Molecular dynamics simulation multifunctional protein natural natural products outbreak ovarian cancer performed Potential predicted Prevent Protein RAS Receptor binding domain Result S-protein SARS-CoV-2 Screening TargetMol the SARS-CoV-2 Virtual screening virus
[DOI] 10.3390/molecules27051740 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Omicron spike glycoprotein receptor binding domain exhibits super-binder ability with ACE2 but not convalescent monoclonal antibody

SARS-CoV-2 오미크론 스파이크 당단백질 수용체 결합 도메인은 ACE2와 수퍼바인더 능력을 나타내지만 회복기 단일클론 항체는 나타내지 않음

Article

Published on 2022-03-012022-09-11
Journal: Computers in biology and medicine [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 antibody binding binding domain Cell Cell fusion center characterized complementarity-determining region complex complexes consequence convalescent COVID-19 Disruption exhibit expected generate glycoprotein host receptor Interaction interactions investigated less light chain mAb mAbs molecular molecular dynamics monoclonal antibody Monoclonal antibody (mAbs) Mutagenesis Mutation Neutralizing omicron Omicron variant promote provided question RBD Receptor binding domain receptor binding domain (RBD) residues S protein SARS-CoV-2 setup spike spike glycoprotein Substitution the S protein Trajectories trajectory Transmissibility variant Viral viral entry virus was used wildtype
[DOI] 10.1016/j.compbiomed.2022.105226 PMC 바로가기 [Article Type] Article

Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants

D614G 및 알파 변이체의 돌연변이 발생과 관련된 SARS-CoV-2 스파이크 단백질의 부위 특이적 글리코실화 패턴의 뚜렷한 변화

Article

Published on 2022-02-262022-09-11
Journal: Glycobiology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alpha variant Analysis arising binding changes in complex contribute coronavirus coronavirus disease Course cryo cryo-EM D614G domain Extensive feature glycan glycans glycosylation host immune responses host receptor immune responses immunogenic information Lineage mass spectrometry Mutation N-glycan N-glycans N-terminal domain Neutralizing antibodies neutralizing antibody NTD pandemic produced proportion SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus site-specific glycosylation. Spike protein Spike proteins Structure the spike protein Transmissibility variants variants of concern virus
[DOI] 10.1093/glycob/cwab102 PMC 바로가기 [Article Type] Article

Current Status of Genetically Modified Pigs That Are Resistant to Virus Infection

Review

Published on 2022-02-172022-10-28
Journal: Viruses [Category] Coronavirus,

Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection

Research Article

Published on 2022-02-152022-10-29
Journal: mBio [Category] COVID-19, MERS,

SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics

Molecular Biosciences

Published on 2022-02-142022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,