SARS-CoV-2 Continuous Genetic Divergence and Changes in Multiplex RT-PCR Detection Pattern on Positive Retesting Median 150 Days after Initial InfectionSARS-CoV-2 지속적인 유전적 분화 및 초기 감염 후 150일의 양성 재검사 중앙값에 대한 다중 RT-PCR 검출 패턴의 변화Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] accumulate amplification Amplification assay analyzed being Chain Reaction change Clinical diagnosis Continuous COVID-19 COVID-19 pandemic Day detection diagnostic Divergence envelope gene epicenter Epidemiology evaluated Evolution Frequency gene amplification Genetic genetic divergence genomes highlight hotspot identify in viral independent Infection initial isolate isolates lab molecular molecular evolution multiplex Multiplex RT-PCR Mutation next generation sequencing NGS Nucleocapsid gene Patient pattern performed polymerase chain polymerase chain reaction positive primer probe Region Reinfection reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA specimen Spectrum target tested utility Viral viral genome viral genomes Viral variants virus WGA whole genome [DOI] 10.3390/ijms23116254 PMC 바로가기 [Article Type] Article
Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network하수도 네트워크를 통해 수집된 폐수에서 SARS-CoV-2 RNA의 존재를 기반으로 프라하 인근 지역의 COVID-19 확산 모니터링Article Published on 2022-06-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 치료법, [키워드] airport carried Chain Reaction collected correlation COVID-19 COVID-19 case COVID-19 epidemic determined by Epidemic Epidemiology gene encoding hospitals hotspot identify Local monitoring multiplex nucleic acid nucleic acids Occurrence plant polymerase chain polymerase chain reaction Prague Precipitation Quantitative reagent Registered reported reverse transcription RNA isolation RT-mqPCR SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA selected shown Spread Treatment TRIzol™ Reagent upstream was determined wastewater Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118343 PMC 바로가기 [Article Type] Article
Evaluation of a Wastewater-Based Epidemiological Approach to Estimate the Prevalence of SARS-CoV-2 Infections and the Detection of Viral Variants in Disparate Oregon Communities at City and Neighborhood ScalesSARS-CoV-2 감염의 유병률을 추정하기 위한 폐수 기반 역학 접근 방식 평가 및 도시 및 인근 지역 규모의 이질적인 오레곤 커뮤니티에서 바이러스 변이체 감지Article Published on 2022-06-012022-09-11 Journal: Environmental health perspectives [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition Affect Analysis Asymptomatic Asymptomatic cases authority B.1 city clinically communicable Community Concentration correlated correlation COVID-19 demography detection disease disparate door eight Epidemiology estimate Estimated event examined greater Health authority hotspot identify indicated Infection infections location log nasal swab neighborhood Pearson positive positive correlations Prevalence Previous studies previous study public health quantified Quantitative R 2 Randomized ranged reliability reported SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants scalability scale sequenced significantly Surveillance tested Treatment Variation variations wastewater [DOI] 10.1289/EHP10289 PMC 바로가기 [Article Type] Article
Visualizing a Field of Research for the Coronavirus Replication in Humans with Knowledge Mapping: Evidence from Web of Science지식 매핑으로 인간의 코로나바이러스 복제 연구 분야 시각화: Web of Science의 증거Article Published on 2022-06-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis Apoptosis apoptotic assembly cause caused Cell cell receptor Clustering cognitive coronavirus Coronavirus replication COVID-19 damaged database Evolution Factors fatal disease feature field Frequency fusion gene sequence global health security globe host adaptation hotspot Human humans indicated inhibit Knowledge mapping living environment mapping mechanism MERS mutant Mutation mutations outbreak package pathogenicity Prevent promote R software Replication replication mechanism Research respiratory diseases S protein severe respiratory disease severe respiratory diseases spike Spike protein Spread the epidemic Transmission unique Variation viral infection Viral protein viral replication virus Virus evolution virus infection Web of Science widespread zone [DOI] 10.1007/s12539-022-00504-4 PMC 바로가기 [Article Type] Article
Qualitative analysis of hotspots and intrusive memories after viewing an aversive film highlights their sensory and spatial featuresRandomized Controlled Trial Published on 2022-04-292022-10-04 Journal: Scientific Reports [Category] 임상, [키워드] Analysis average coding COVID-19 feature Features FIVE highlight hotspot memory MOST participant Population qualitative analysis Randomized controlled trial Registered reported Result trauma Validity [DOI] 10.1038/s41598-022-10579-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Rapid Assay for the Therapeutic Drug Monitoring of EdoxabanEdoxaban의 치료 약물 모니터링을 위한 신속한 분석Article Published on 2022-04-172022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile administration Anticoagulant blood plasma Care Concentration detect DOAC drug edoxaban followed by hotspot HPLC indicated lab limit lowest methanol monitoring pathology Patient pharmacokinetic Pulmonary embolism quantification R 2 Raman spectroscopy Rapid receiving reporter Safe SARS-CoV-2 infections standard sample standard samples surface enhanced Raman spectroscopy therapeutic therapeutic drug Therapeutic Drug Monitoring therapeutic index thiol Treatment Variability was used [DOI] 10.3390/biom12040590 PMC 바로가기 [Article Type] Article
Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis백신 이전 시대의 연령별, 시기별, 지역별 코로나19 감염-치명률 변화: 체계적 분석Article Published on 2022-04-162022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] a metric accounted adjusted African age age distribution Analysis Asian baseline Bayesian Care caused Clinical practice comorbid condition comorbid conditions country covariate covariates COVID-19 COVID-19 disease COVID-19 mortality death decrease determinant determinants disease Diseases distribution effort elevated estimate Evolution excluded exclusion criteria Factor foundation Geography Greece group health system health-care health-care system help heterogeneity Hierarchical highest hotspot identify IFR implication in some include indicate individual infections Infectious diseases interquartile range Intervention introduced Japan likelihood Local location lowest measure median Melinda Gate Melinda Gates meta-regression metric Mortality mortality rate mortality risk Moss obesity observation occurred Oman outbreak parameter pathogen physical distancing measures Population population prevalence Portugal post-hoc analysis Potential predictor Prevalence progression provide Regression reported Research resulting risk risk stratification SARS-CoV-2 virus sensitivity Seroprevalence seroprevalence survey Seven severe cases severity of COVID-19 Spain systematic analysis the disease the median the SARS-CoV-2 virus Transmission treatment for COVID-19 understanding USA Vaccine variants Variation widespread with COVID-19 [DOI] 10.1016/S0140-6736(21)02867-1 PMC 바로가기 [Article Type] Article
Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron MutationsSARS-CoV-2 스파이크 변이체 복합체와 숙주 수용체의 결합 및 알로스테릭 상호작용에 대한 컴퓨터 시뮬레이션 및 네트워크 기반 프로파일링: 델타 및 오미크론 돌연변이의 기계적 효과 분석Article Published on 2022-04-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 complexes ACE2 host receptor allosteric communications analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding energetics binding energy binding interaction Community Community network complexes computer constellation contribute Critical Delta Effect energetics Epitopes escape mutants examined functional generate Host host receptor hotspot identify immune evasion integrity Interaction interactions Local MD simulation modulate molecular molecular dynamics Mutation mutational scanning N501Y network analysis omicron Omicron variants plasticity Profiling RBD-ACE2 residue responsible S protein S-RBD SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity signal transmission. Simulation spike Spike protein the RBD the SARS-CoV-2 Transmissibility Transmission variant variants virus [DOI] 10.3390/ijms23084376 PMC 바로가기 [Article Type] Article
Mutational scanning of spike RBD protein for enhanced ACE2 affinity emerging Southeast Asia in the late transmission phase후기 전송 단계에서 동남아시아 신흥 ACE2 친화력 향상을 위한 스파이크 RBD 단백질의 돌연변이 스캐닝Article Published on 2022-04-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] ACE2 ACE2 binding analyzed Asia binding changed Cluster conserved coronavirus COVID-19 COVID-19 pandemic Deleterious Diversity dominant effective Epitopes evaluate facilitate higher affinity hotspot Human Human Security in silico MD simulations measure mutated Mutation Neutralizing Outbreaks Protein Quality of life RBD mutation RBD protein RBD region Salt Bridge SARS-CoV-2 SARS-CoV-2 virus stability the disease the RBD the SARS-CoV-2 virus Transmission transmitted Treatment vaccination Variation virus [DOI] 10.1038/s41598-022-09999-9 PMC 바로가기 [Article Type] Article
In.To. COVID-19 socio-epidemiological co-causality Research Published on 2022-04-062022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy ARIMA aversion can be used COVID-19 disease dissimilarity effective Epidemic epidemiological expressed healthcare highest Hospitalization hotspot incidence Infection information introduced media misinformation Mumbai New outcomes predict public health reliability respond risk Risk perception social media Spread Surveillance value Volume [DOI] 10.1038/s41598-022-09656-1 [Article Type] Research