Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein자기 마이크로비드 친화성 선택 스크리닝의 발전: SARS-CoV-2 스파이크 단백질에 대한 천연 리간드의 발견Article Published on 2022-01-052022-09-11 Journal: Journal of the American Society for Mass Spectrome [Category] Coronavirus, SARS, 신약개발, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance affinity Amino acid amino acid sequence angiotensin Angiotensin converting enzyme-2 antibodies applied approaches binding caused complex coronavirus COVID-19 enzyme glycyrrhiza High-resolution HPLC human ACE2 human cell human cells include Interaction licochalcone a Ligand ligands Like mass spectrometry Microbead natural peptide pharmacological Prevent Protein subunit receptor robotics S1 protein SARS-CoV-2 SARS-COV-2 infection Selection sensitivity sequence severe acute respiratory syndrome Coronavirus small molecule Small molecules spike Spike protein subunit Tandem mass spectrometry targets the S1 protein the SARS-CoV-2 therapeutic agent therapeutic agents throughput treat virus spike protein [DOI] 10.1021/jasms.1c00318 PMC 바로가기 [Article Type] Article
Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 VirusesHIV-1 슈도바이러스 및 SARS-CoV-2 바이러스에 대한 글리시리진 니코틴산 유도체의 항바이러스 활성 합성 및 시험관 내 연구Article Published on 2022-01-042022-09-10 Journal: Molecules [Category] 치료제, [키워드] activity acylation addition agent antiviral action antiviral activity Antiviral agents broad spectrum Cell Cell culture characteristics of patient characterized clinical complications co-morbidities comparable Compound COVID-19 derivative derivatives drug entry inhibitors exhibited General population Glycyrrhizinic acid higher risk HIV HIV-1 HPLC human immunodeficiency virus type 1 in vitro inhibit SARS-CoV-2 inhibitory activity investigated morbidities MTT nicotinates of glycyrrhizic acid nicotinic acid patients pseudovirus pseudovirus infection pseudoviruses Remdesivir Replication resulting SARS-CoV-2 SARS-CoV-2 replication shown strain subtype suggested synthesis target cell Toxicity Vero E6 Vero E6 cell VERO E6 cells virus entry was tested [DOI] 10.3390/molecules27010295 PMC 바로가기 [Article Type] Article
Elevated blood favipiravir levels are inversely associated with ferritin levels and induce the elevation of uric acid levels in COVID-19 treatment: A retrospective single-center study상승된 혈액 파비피라비르 수치는 페리틴 수치와 반비례하고 COVID-19 치료에서 요산 수치 상승을 유도합니다: 후향적 단일 센터 연구Article Published on 2022-01-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료법, 치료제, [키워드] accumulation administration affected affecting alteration association Blood Blood level blood levels Combination Comorbidities COVID-19 COVID-19 patient COVID-19 severity COVID-19 treatment Critical Efficacy and safety Elevation enrolled evaluated Factor Favipiravir ferritin ferritin level FPV Gender General Hospital hospital HPLC identify independent induce input investigated laboratory data less measurement performed presence of comorbidities retrospective Retrospective study searched Serum ferritin significant increase significantly single-center study statistical subject Treatment uric acid variable were measured [DOI] 10.1016/j.jiac.2021.10.011 PMC 바로가기 [Article Type] Article
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathwayYindan Jiedu 과립은 NF-κB 신호 전달 경로를 억제하여 신종 코로나바이러스 감염증(COVID-19) 환자에서 항염증 효과를 나타냅니다.Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, 임상, [키워드] accompanied Activation acute lung injury amyloid A Analysis animals anti-inflammatory effect Anti-inflammatory effects assigned caused CD4 cells clinical Clinical research Compound compounds control group coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 progression Cytokines death decrease disease dissipation docking Effect enrichment analysis erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Factor Granule high-performance liquid chromatography histological HPLC IL-1β IL-6 immune in vitro increase in Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines inflammatory factors inhibit inhibiting Interaction IκBα kaempferol lesion Ligand ligands lipopolysaccharide lung Lung injury Luteolin mass spectrometry mechanism mechanism of action molecular docking Negative conversion network model NF-κB NF-κB pathway NF-κB signaling NF-κB signaling pathway nuclear translocation nucleic acid overlapping p65 pandemic participant pathway Patient Pharmacology Pharmacology analysis Phosphorylation progression propensity score matching PSM quercetin Randomly recruited sedimentation rate serum serum amyloid significantly strong interaction suppressed T cell Tandem mass spectrometry target targets therapeutic effect therapeutic effects TNF-α viral nucleic acid were measured Yindan jiedugranules. [DOI] 10.1016/j.phymed.2021.153784 PMC 바로가기 [Article Type] Randomized Controlled Trial
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered SynthesisReview article Published on 2021-12-092022-10-05 Journal: Organic Process Research & Development [Category] 치료제, [키워드] acetone antivirals approach average carried COVID-19 cytidine described EIDD-2801 HPLC isopropanol MK-4482 molnupiravir Process purification reagent solvent synthesis [DOI] 10.1021/acs.oprd.1c00219 [Article Type] Review article
Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking TechnologyResearch Article Published on 2021-10-112022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 3CL ACE2 Analysis Basis binding energy Clinical efficacy component Compound COVID-19 database docked enrichment analysis Gene ontology GeneCard HPLC ingredient injection JAK-STAT signaling pathway KEGG KEGG pathway Kyoto material mechanism of action molecular docking network network pharmacology OMIM pathway enrichment Pathways Pharmacology PI3K potential mechanism PPI protease protein-protein interaction RdRP Research Result SEA Spike protein SwissTargetPrediction target targets technology the S protein therapeutic target Treatment was used were used [DOI] 10.1155/2021/7697785 PMC 바로가기 [Article Type] Research Article
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine HerbsResearch Article Published on 2021-09-282022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] 50% effective concentration acute respiratory syndrome addition antiviral activity autogenous caused Chinese component contribute coronavirus Coronavirus disease 2019 COVID-19 cysteine death drug target ecosystem effective Herb High-resolution HPLC in vitro inhibit SARS-CoV-2 inhibitor inhibitory activity inhibitory concentration leupeptin M pro main protease Medicine metabolite microbial Microbiome outbreak pandemic plant plants plants, microbiome, and microbial metabolites ecosystem protease Proteases regulate SARS-CoV-2 Serine strain TCM TCM modernization research thought Traditional treating COVID-19 Treatment Vero cells Wuhan [DOI] 10.1128/mBio.02220-21 PMC 바로가기 [Article Type] Research Article
Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-MethyltransferasemRNA 캡 구아닌 N7-메틸트랜스퍼라제를 표적으로 하는 잠재적인 SARS-CoV-2 항바이러스제의 식별 및 평가Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] analyzed antiviral activity antiviral agent approach assays binding binding site Cell Compound COVID-19 COVID-19 pandemic dot blot Drug discovery ENCODE enzyme FIVE Fluorescence fluorescence anisotropy Fluorescence assay guanine HPLC identification identify inhibitor Inhibitor screening inhibitory effect Inhibitory effects insight involved mRNA novel nsp14 SARS-CoV-2 screened Structure tested therapeutic intervention therapeutic interventions to define [DOI] 10.1016/j.antiviral.2021.105142 PMC 바로가기 [Article Type] Article
Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First WaveArticle Published on 2021-08-242022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] 95% CI Admission Adult patient age analysed association clinical trial coronavirus COVID-19 Critical illness Culture Gender greater Hospital admission HPLC ICU ICU admission immunoassay Impact intubation Level male mean value Micronutrient micronutrients Mortality Nasopharyngeal swab Older outcome pandemic Patient PCR performed plasma analysis positive SARS-CoV-2 severe COVID-19 patient Spanish standard error the SARS-CoV-2 trace elements tracheal Treatment university hospital variable Vitamin vitamin A Vitamin C vitamins Wave [DOI] 10.3390/metabo11090565 PMC 바로가기 [Article Type] Article